Comprehensive Handbook of Alcohol Related Pathology

Comprehensive Handbook of Alcohol Related Pathology, 1st Edition

Comprehensive Handbook of Alcohol Related Pathology, 1st Edition,Victor Preedy,Ronald Ross Watson,ISBN9780080502311

Preedy   &   Watson   

Academic Press



Comprehensive Handbook of Alcohol Related Pathology is a "one-stop-shop" for all researchers involved in the field of alcohol-related harm at the whole body or cellular level.

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Key Features

*Over 100 chapters conveniently divided into 3 sections
*Represents a 'one-stop-shop' of information with suitable indexing of the various pathways and processes
*Each chapter is highly illustrated with tables as well as figures


This comprehensive handbook is a "one-stop-shop" for all researchers involved in the field of alcohol-related harm at the whole body or cellular level. Over 100 chapters provide abundant information of a wide range of topics that extend from the evolutionary aspects of alcohol consumption and the prevalence of alcohol misuse to programmed cell death. Each chapter is highly illustrated with tables and figures making this a valuable reference for students, clinicians and researchers alike.


Researchers involved in the field of alcohol-related harm, institutions, libraries, PhD students, clinicians and pathologists.

Victor Preedy

Victor R. Preedy BSc, PhD, DSc, FRSB, FRSPH, FRCPath, FRSC is a senior member of King's College London. He is also Director of the Genomics Centre and a member of the Faculty of Life Sciences and Medicine. Professor Preedy has longstanding academic interests in substance misuse especially in relation to health and well being. He is a member of the Editorial Board of Drug and Alcohol Dependence and a founding member of the Editorial Board of Addiction Biology. In his career Professor Preedy was Reader at the Addictive Behaviour Centre at The University of Roehampton, and also Reader at the School of Pharmacy (now part of University College London; UCL). Professor Preedy is Editor of the influential works The Handbook Of Alcohol Related Pathology, The Neuropathology of Drug Addictions and Substance Misuse and The Handbook of Cannabis and Related Pathologies (all published by Academic Press-Elsevier). Professor Preedy graduated in 1974 with an Honours Degree in Biology and Physiology with Pharmacology. He gained his University of London PhD in 1981. In 1992, he received his Membership of the Royal College of Pathologists and in 1993 he gained his second doctoral degree (DSc). Professor Preedy was elected as a Fellow of the Institute of Biology in 1995 and also as a Fellow to the Royal College of Pathologists in 2000. He was then elected as a Fellow of the Royal Society for the Promotion of Health (2004) and The Royal Institute of Public Health and Hygiene (2004). In 2009, Professor Preedy became a Fellow of the Royal Society for Public Health and in 2012 a Fellow of the Royal Society of Chemistry. To his credit, Professor Preedy has published over 600 articles, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews and numerous books and volumes.

Affiliations and Expertise

Department of Dietetics, King's College London, UK

View additional works by Victor R. Preedy

Ronald Ross Watson

Ronald Ross Watson PhD is a professor of Health Promotion Sciences in the University of Arizona Mel and Enid Zuckerman College of Public Health. He was one of the founding members of this school serving the mountain west of the USA. He is a professor of Family and Community Medicine in the School of Medicine at the University of Arizona. He began his research in public health at the Harvard School of Public Health as a fellow in 1971 doing field work on vaccines in Saudi Arabia. He has done clinical studies in Colombia, Iran, Egypt, Saudi Arabia, and USA which provides a broad international view of public health. He has served in the military reserve hospital for 17 years with extensive training in medical responses to disasters as the chief biochemistry officer of a general hospital, retiring at a Lt. Colonel. He published 450 papers, and presently directs or has directed several NIH funded biomedical grants relating to alcohol and disease particularly immune function and cardiovascular effects including studying complementary and alternative medicines. Professor Ronald Ross Watson was Director of a National Institutes of Health funded Alcohol Research Center for 5 years. The main goal of the Center was to understand the role of ethanol-induced immunosuppression on immune function and disease resistance in animals. He is an internationally recognized alcohol-researcher, nutritionist and immunologist. He also initiated and directed other NIH-associated work at The University of Arizona, College of Medicine. Dr. Watson has funding from companies and non-profit foundations to study bioactive foods’ components in health promotion. Professor Watson attended the University of Idaho, but graduated from Brigham Young University in Provo, Utah, with a degree in Chemistry in 1966. He completed his Ph.D. degree in 1971 in Biochemistry from Michigan State University. His postdoctoral schooling was completed at the Harvard School of Public Health in Nutrition and Microbiology, including a two-year postdoctoral research experience in immunology. Professor Watson is a distinguished member of several national and international nutrition, immunology, and cancer societies. Overall his career has involved studying many foods for their uses in health promotion. He has edited 120 biomedical reference books, particularly in health and 450 papers and chapters. His teaching and research in foods, nutrition and bacterial disease also prepare him to edit this book. He has 4 edited works on nutrition in aging. He has extensive experience working with natural products, alcohol, exercise, functional foods and dietary extracts for health benefits and safety issues, including getting 12 patents. Dr. Watson has done laboratory studies in mice on immune functions that decline with aging and the role of supplements in delaying this process as modified by alcohol and drugs of abuse.

Affiliations and Expertise

Mel and Enid Zuckerman College of Public Health, School of Medicine, University of Arizona, Tucson, AZ, USA

View additional works by Ronald Ross Watson

Comprehensive Handbook of Alcohol Related Pathology, 1st Edition

Contributors xiii
Preface xxix
Foreword xxxi
Volume 1
Part I: General Aspects of Alcohol Toxicity, Consumption, and Disease 1
1. Evolutionary and Historical Aspects of Ethanol Ingestion 3
Robert Dudley
2. Alcohol Metabolism: General Aspects 15
Charles S. Lieber
3 Intake of Different Alcoholic Beverages and Life-style and Psychosocial Factors 27
John Barefoot and Morten Grønbæk
4. Genetic Aspects of Alcohol Metabolism: An Overview 31
Stephen J. Marshall and Geoff K. Chambers
5. Predictors of Alcohol Consumption 49
Kari Poikolainen
6. Binge Drinking: Patterns, Explanations, and Policy 59
Holly E. Ventura, Chris L. Gibson, J. Mitchell Miller and Alex R. Piquero
7. Breath and Blood Alcohol 75
Marion Pavlic and Petra Grubwieser
8. Effects of Food and Body Composition on Blood Alcohol Levels 87
Harold Kalant
9. Disposal of Ethanol Carbon Atoms 103
M-A. Cornier
10. Effect of Alcohol on Water and Sodium Homeostasis 111
Ramón Rodrigo and Gonzalo Rivera
11. Energy from Alcohol 121
Michael J. Haas
12. The Mediterranean Diet and the Contribution and Role of Alcohol 135
Maria Isabel Covas
13. The Role of Alcohol in Injury Deaths 147
Philippe Lunetta and Gordon S. Smith
14. Death from Alcohol Poisoning 165
James A. Crampton and Kathleen Berry
15. Alcohol and the Workplace 175
Valentino Patussi and Laura Mezzani
16. Alcohol Misuse in Adolescents: Epidemiology, Clinical Characteristics,
Diagnosis, and Treatment 181
Dawn L. Thatcher and Duncan B. Clark
17. Alcohol Misuse in Adolescents: Individual Differences, Prevention,
Identification, and Intervention 195
Rebecca Lebeau-Craven, Holly A. Sindelar, James Murphy and Nancy P. Barnett
PreedyVol1_FM.qxd 19/11/04 9:03 PM Page v
18. What is the Impact of Alcohol on Learning in University Students? 215
Bert Aertgeerts
19. The Relationship Between Alcohol Misuse and the Homelessness 221
Colleen Clark and Alexander R. Rich
20. Alcohol and Sport Activities: Spectator’s Perspective 241
Eli Torild Hellandsjo Bu
Part II: Damage/Disease
(i) General Aspects of Pathology 251
21. An Overview of Pathologies Occurring in Alcohol Abusers 253
Valentino Patussi, Laura Mezzani and Emanuele Scafato
22. Gender Differences in Alcohol Pathology 261
Joaquim Fernández-Solà, Josep-María Nicolás, Romon Estruch and
Alvaro Urbano-Márquez
23. Psychological Effects of Alcohol Misuse 279
Marc Walter, Gerhard Dammann and Burghard F. Klapp
24. The Effect of Alcohol on Quality of Life 295
Paul J. Allison
25. Alcohol and Road Accidents 309
Andrea Fabbri, Giulio Marchesini and Alberto Vandelli
26. Trauma and Alcohol 321
Richard D. Blondell
27. Clinical Implications of Alcohol Misuse for Surgery 337
S. Shourie, P.S. Haber, R. Boughton, and K.M. Conigrave
28. Fetal Alcohol Spectrum Disorder 349
Christina D. Chambers
29. Nutritional Status in Alcoholics 361
Romon Estruch, Emilio Sacanella, Joaquim Fernández-Solà and Josep-Maria Nicolás
30. Alcohol and Body Composition 377
Giovanni Addolorato, Carlo Ancona, Esmeralda Capristo, Giovanni Gasbarrini and the
Alcohol Related Diseases Study Group
31. Beneficial Components of White Wine 387
A.A.E. Bertelli
32. Polyphenols and Alcohol: Complementary Mechanisms for the Protective
Effects of Moderate Wine Consumption 393
A. Di Castelnuovo, S. Rotondo and G. de Gaetano
33. Overview of ALDH Polymorphism: Relation to Cardiovascular Effects of Alcohol 409
Shih-Jiun Yin and Giia Sheun Peng
34. Overview on the Effects of Amount and Type of Alcohol on Morbidity and Mortality 425
Morten Grønbæk and Lina Steinrud Mørch
35. Alcohol-related Mortality in Russia 441
A.V. Nemtsov and P.P. Ogurtsov
(ii) Organ Damage 465
36. Epidemiology and Risk Factors Involved in Alcoholic Liver Disease 467
Ulrik Becker
37. Polymorphism and Alcoholic Liver Disease 481
José María Ladero
38. Liver Injury During Alcohol Use and Withdrawal 491
Abraham P. Bautista
39. Alcohol Consumption and Diabetes Mellitus 501
Angelo Avogaro and Antonio Tiengo
40. Alcoholic Ketoacidosis 511
Hitender Jain and M. Duggal
41. Alcohol, Alcoholism and Effects on the Kidney and Kidney Disease 519
Judith H. Veis
42. Alcohol Intake and the Lower Urinary Tract 527
C.P. Arun
43. Alcohol and Prostate Cancer 531
Katrine Albertsen and Morten Grønbæk
44. Oral Health and Alcohol 551
Jukka H. Meurman and Riitta Suuronen
Volume 2
45. Alcohol and the Gastrointestinal Tract 557
Gerlinde Egerer, Felix Stickel and Helmut K. Seitz
46. Alcohol, ALDH2 Genotypes and Intestinal Cancer 571
Motoi Murata
47. Alcohol and Pancreatitis 577
Alexander Schneider, Stephan L. Haas and Manfred V. Singer
48. The Skin and Alcohol 599
Elisabeth Higgins
49. Alcohol, Blood Pressure and Hypertension 607
Ian B. Puddey, Renate R. Zilkens and Lawrence J. Beilin
50. Alcohol and Stroke 627
Douglas A. Dulli and Madeleine C. Geraghty
51. Alcoholic Cardiomyopathy 647
Michael Sander, Christian von Heymann, Jan Braun,
Adrian Borges and Claudia Spies
52. Epidemiologic Aspects of ALDH2 Genotypes and Cardiovascular Parameters 659
Tomonori Okamura
53. Alcoholic Myopathy: Clinical Aspects 671
Joaquim Fernández-Solà, Josep-María Nicolás
Romon Estruch, Emilio Sacanella, Joseph-María Grau and
Alvaro Urbano-Márquez
54. Alcohol and the Eye: Friend or Foe 693
John R. Trevithick and Kenneth P. Mitton
55. Marchiafava–Bignami Disease in Alcoholism 713
Yahya Çelik
56. Peripheral Neuropathy 719
Angelo Ammendola and Francesco Bravaccio
(iii) Cells, Pathways, Interactions, Processes 733
57. Defects in Methionine Metabolism: Its Role in Ethanol-induced Liver Injury 735
Kusum K. Kharbanda and Anthony J. Barak
58. Roles of Kupffer Cells in Alcoholic Liver Disease 749
Yoshiyuki Takei, Nobuyuki Enomoto, Kenichi Ikejima, Shunhei Yamashina,
Tsuneo Kitamura and Nobuhiro Sato
59. The Role of the Stellate Cell in Alcohol Mediated Tissue Injury 757
R.G. Batey and Jianhua Wang
60. The Role of T Lymphocytes in the Pathogenesis of Alcoholic Liver Disease 763
Q. Cao and R.G. Batey
61. Oxidative Stress in Alcoholic Liver Disease: Clinical Studies 775
Carmela Loguercio and Alessandro Federico
62. The Relationship between Alcohol-induced Apoptosis and Oxidative Stress in the Liver 785
Juan Sastre, Juan Bautista Miñana, Federico V. Pallardó and José Viña
63. Alcohol and HIV Interactions in the Natural History and Treatment of HIV/AIDS 799
Thomas F. Kresina and Laura W. Cheever
64. Alcohol and Hepatitis Virus Interactions in Liver Pathology 819
Bin Gao
65. Moderate Alcohol and Fibrosis in Chronic Viral Hepatitis 833
Johan Westin
66. Ethanol–Taurine Interactions in the Brain: Mechanisms and
Pathophysiological Implications 845
Jan Albrecht, Magealena Zielinska, Jeffrey W. Allen,
Offie P. Soldin and Michael Aschner
67. The Effect of Ethanol on Ion Channels in the Brain: A New Look 855
Hugh E. Criswell and George R. Breese
68. A Nitric Oxide Signaling Pathway Protects the Developing Brain against
Alcohol-induced Neuronal Death 871
Ana M. Hutton Kahrberg, Nicholas J. Pantazis, Ross A. McKim and Daniel J. Bonthius
69. Signaling Pathways in the Heart and Moderate Alcohol Intake 887
Mary O. Gray
70. Effects of Alcohol on Vascular Function 901
Jocelyn L. Cook and Sandra T. Davidge
71. Vascular and Biochemical Effects of Moderate Alcohol Consumption:
Mechanisms of Protection Against Cardiovascular Disease 911
Asf je Sierksma, Diederick E. Grobbee and Henk F.J. Hendriks
72. Alcohol and Xenobiotics in Placenta Damage 921
Cleofina Bosco
73. Molecular Mechanisms in Fetal Alcohol Syndrome: Shh-signaling 937
Sara C. Ahlgren
74. The Process of Bacterial Translocation and Implications for Health in Alcoholics 949
Valeria Bender Braulio
75. Alcohol, Altered Gut Permeability, and Endotoxins 965
Alexandr Parlesak
76. Hormonal Responses in Alcoholism 979
Bernard Campillo
77. Alcohol-induced Changes in the GH–IGF Axis 991
Charles H. Lang and Robert A. Frost
78. Mechanisms in Prostate Damage by Alcohol 1007
Jose A. Castro and Gerardo D. Castro
79. Signaling Pathways in Human Breast Cells in Response to Alcohol:
Mechanisms for Alcohol-induced Breast Cancer 1017
Ernest B. Izevbigie
80. The Ubiquitin–Proteasome System in Alcohol-Induced Pathology 1027
Terrence M. Donohue, Jr. and Samuel W. French
81. Alcohol and Alkylating Agents 1041
David B. Couch
82. DNA Damage Resulting from Alcohol Abuse with Special Reference
to the Brain 1049
Philip J. Brooks, Jacob A. Theruvathu and Raghu G. Nath
83. Purine Metabolism and the Influence of Alcoholic Beverages 1069
Y. Suwa
84. The Role of PKC Isozymes in Mediating Responses to Ethanol 1083
John S. Ellingson
85. Ethanol Modulation of cAMP-dependent Protein Kinase Subunits Activity:
Mechanisms and Functional Consequences 1099
Anastasia Constantinescu
86. Adhesion Molecules and Alcohol Consumption 1113
Emilio Sacanella, Romon Estruch, Josep-Maria Nicolás, and Joaquim Fernández-Solá
87. Glucose-regulated Stress Proteins (GRPs) and Alcohol 1127
Eckhard Mühlbauer and H. Rommelspacher
88. Heat Shock Proteins and Alcohol 1141
Luisa Schiaffonati
89. Role of Oxidative Stress in Alcohol-Induced Mitochondrial Dysfunction 1153
Shannon M. Bailey
90. Alcohol and Apoptosis 1175
Benita L. McVicker, Dean J. Tuma, Amin A. Nanji and Carol A. Casey
Volume 3
91. Alcohol and Fatty Acid Ethyl Esters 1195
Raneem O. Salem and Michael Laposata
92. Modification of Proteins by Reactive Ethanol Metabolites:
Adduct Structure, Functional and Pathological Consequences 1209
Simon Worrall and Geoffrey M. Thiele
93. The Effect of Acetaldehyde on Plasma 1223
Arthur S. Brecher
94. Autoantibodies in Alcohol-related Tissue Diseases 1245
Emanuele Albano and Matteo Vidali
95. Alcohol-induced Membrane Damage 1253
Junko Adachi, Hideyuki Nushida, Yasuhiro Ueno and Victor R. Preedy
96. Alcohol Abuse and Eating Disorders 1263
Marlene B. Schwartz and Rajita Sinha
97. The Relationship Between Obesity and Alcoholic Pathology 1277
Daniel Bunout, María Pía De la Maza and Sandra Hirsch
98. Protein Deficiency and Alcohol: Interactions and Organ Effects 1289
Emilio González-Reimers and Francisco Santolaria-Fernández
99. Tryptophan Metabolism and Alcoholism 1303
Abdulla A.-B. Badawy
Part III: Selective Methods Used in Alcohol Research 1325
100. Selective Methods Used in Alcohol Research: Screening in Primary Care – Methods
and Approaches 1327
Adam J. Gordon, Joseph Conigliaro and David A. Fiellin
101. Psychometric Assessment of Alcohol Use 1347
Andrew J. Levine, Steven A. Castellon and Charles H. Hinkin
102. Self-reported Intake of Alcohol: Methods and Approaches 1367
Ulrik Kesmodel
103. Use of the DSM-IV: Methods and Approaches 1383
Deborah Hasin and Rachel Y. Waxman
104. The Alcohol-related Problems Survey: Developing and
Testing a Screening Measure for Older Adults 1403
Arlene Fink
105. The Rapid Alcohol Problems Screen: Methods and Application 1415
Cheryl J. Cherpitel
106. Methods for Determining Blood Alcohol Concentration: Current and
Retrospective 1429
Kate B. Carey and John T.P. Hustad
107. Urinary Markers of Alcohol Consumption 1445
Anja Kroke and Jutta Dierkes
108. Methods for Measuring Genetic Variations in ADH
and SLDH Loci: A Practical Approach 1459
Stephen J. Marshall, Geoff K. Chambers and Darren Day
109. Histological Localization of Alcohol Dehydrogenase: Methods,
Approaches and Applications 1475
Susana E. Martínez, Sergio Porté, Julia Vaglenova, Xavier Parés and Jaume Farrés
110. Assays for Alcohol and Aldehyde Dehydrogenase: Methods,
Approaches and Applications 1489
Stewart Campbell and Peter M. Timms
111. Detecting ADH and ALDH Enzymes in Cells and Tissues using Western Blotting 1501
Connie Cheung and Camilla K. Smith Pease
112. Use of Selectively Bred Alcohol-preferring Rats to Study Alcohol
Abuse, Relapse and Craving 1515
R.L. Bell, Z.A. Rodd, J.M. Murphy and W.J. McBride
113. Animal Models of Chronic Alcohol-Induced Liver Damage 1535
Jason C. Lambert and Gavin E. Arteel
114. Acute Ethanol Dosing Regimens: Methods and Approaches 1551
Ernest L. Abel
115. Use of Isolated Cells in the Study of Ethanol-Induced Hepatotoxicity 1559
Dahn L. Clemens
116. Animal Models of Fetal Alcohol Syndrome: Methods and Approaches 1573
George K. Acquaah-Mensah
117. Genetically Engineered Animals in Alcohol Research 1583
David F. Werner, Dev Chandra and Gregg E. Homanics
118. cDNA Arrays in Alcohol-Related Pathology: Methods and Approaches 1597
R.S. Gooch, T.J. Worst, W.M. Freeman and K.E. Vrana
119. Practical Methods for Determining mRNA Levels in Alcohol-Exposed
Tissues and Its Application to Experimental Pathology 1611
Tatsuo Nakahara, Ross J. Hunter, Victor R. Preedy, Colin R. Martin, and
Matthew E. Reilly
120. Diagnosis of Fetal Alcohol Syndrome: Measurement of the
Facial Dysmorphology 1619
Ernesta M. Meintjes and Tania S. Douglas
121. Nuclear Magnetic Resonance: Methods and Application to
Alcohol Effects in the Liver 1635
Marie-Christine-Beauvieux and Jean-Louis Gallis
Index 1651

Quotes and reviews

"...an excellent addition to a reference library and to the field of addictionology. ...a great reference -- all you want to know in 2005 regarding alcohol and its medical consequences. ...I highly recommed it for researchers in the field and medical libraries."
- DOODY'S (2005)
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