Hematology, 1st Edition

Landmark Papers of the Twentieth Century

Hematology, 1st Edition,Marshall Lichtman,Laurence Boxer,Edward Henderson,Sanford Shattil,Jerry Spivak,ISBN9780124485105

Lichtman   &   Boxer   &   Henderson   &   Shattil   &   Spivak   

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Key Features

@introbul:Key Features
@bul:* Contains 86 landmark articles from the last 100 years of research in clinical hematology
* Includes expert commentaries discussing the impact of each article
* Cites approximately 1000 preceding or subsequent articles of consequence in the commentaries
* Includes the English translations of nine articles originally published in other languages
* Provides easy access to several papers that may no longer be found in libraries


This book is a centennial volume celebrating the enormous progress made in hematology in the 20th century. It is edited by Marshall Lichtman, a distinguished senior hematologist, past president of the American Society of Hematology, and co-editor of the leading text in the field.
Hematology is a compendium, with commentaries, of the most important papers published in the field from 1900-1999. The book will be useful for reference--many of the older papers can no longer be found in most libraries, yet are still referred to in current publications, especially review articles--as well as teaching.
The Editor and a team of associate editors have included the most important papers covering eight categories: anemia; phagocytic cells; platelets; coagulation and thrombosis; lymphocytes and immune disorders; transfusion medicine; hematologic malignancies and therapeutics; and laboratory developments. Each paper is accompanied by a 1-2 page commentary explaining its impact, and references to the developments that resulted.


Hematologists, pediatric and adult hematologists, oncologists, transfusion medicine MDs, hematopathologists, internists, fellows and residents, molecular biologists and immunologists interested in the structure and function of blood cells, and geneticists.

Marshall Lichtman

Affiliations and Expertise

University of Rochester School of Medicine, New York, U.S.A.

Laurence Boxer

Affiliations and Expertise

University of Michigan Medical Center, Ann Arbor, U.S.A.

Edward Henderson

Affiliations and Expertise

Veterans Administration, Western New York Health Systems, Buffalo, U.S.A.

Sanford Shattil

Affiliations and Expertise

Scripps Research Institute, La Jolla, California, U.S.A.

Jerry Spivak

Affiliations and Expertise

Johns Hopkins University School of Medicine, Baltimore, Maryland, U.S.A.

Hematology, 1st Edition

Preface Acknowledgments Acknowledgment of Permissions from Publishers and Organizations Section 1 Descriptions of Hematologic Diseases or Syndromes Chronic Cyanosis, with Polycythemia and Enlarged Spleen: A New Clinical Entity American Journal of the Medical Sciences 126:187-201 Commentary Landmark Paper Ueber paroxysmale H~iemoglobinurie [Concerning Paroxysmal Hemoglobinuria] Muenchener Medizinische Wochenschrift 51:1590-1593 Commentary Landmark Paper Translation Pathog6ne de l'ict6re cong6nital de l'adulte [Pathogenesis of Congenital Jaundice of Adults] Semaine Mddicale 27:25-29 Commentary Landmark Paper Translation Peculiar Elongated and Sickle-Shaped Red Corpuscles in a Case of Severe Anemia Archives of Internal Medicine 6:517-521 Commentary Landmark Paper Hereditare h~iemorrhagische Thrombasthenie. Ein Beitrag zur Pathologie der B lutpl~ittchen [Hereditary Hemorrhagic Thrombasthenia: A Contribution on the Pathology of Blood Platelets] Jahrbuch fiir Kinderheilkunde 88:113-141 Commentary Landmark Paper Translation Mononuclear Leukocytosis in Reaction to Acute Infections ("Infectious Mononucleosis") Johns Hopkins Hospital Bulletin 31:410-417 Commentary Landmark Paper Chronic Arthritis in the Adult, Associated with Splenomegaly and Leucopenia Johns Hopkins Hospital Bulletin 35:16-20 Commentary Landmark Paper A Series of Cases of Splenomegaly in Children with Anemia and Peculiar Bone Changes Transactions of the American Pediatric Society 37:29-30 Commentary Landmark Paper An Acute Febrile Pleiochromic Anemia with Hyaline Thrombosis of Terminal Arterioles and Capillaries: An Undescribed Disease Archives of Internal Medicine 36:89-93 Commentary Landmark Paper Famili~e infantile perniziosaartige Anamie (pernizi6ses Blutbild und Konstitution) [Familial Infantile Pernicious-Like Anemia (Pernicious Blood Picture and Constitution)] Jahrbuch fiir Kinderheilkunde 117:257-280 Commentary Landmark Paper Translation o , Uber hereditare Pseudoh~imophilie [On Hereditary Pseudohemophilia] Acta Medica Scandinavica 76:521-549 Commentary Landmark Paper Translation The Etiology of Primary Granulocytopenia (Agranulocytic Angina) Journal of the American Medical Association 102:755-758 Commentary Landmark Paper Tropical Macrocytic Anemia: Its Relation to Pernicious Anaemia Lancet 2:416--421 Commentary Landmark Paper Incipient Myelomatosis or "Essential" Hyperglobulinemia with Fibrinogenopenia: A New Syndrome? Acta Medica Scandinavica 117:216-247 Commentary Landmark Paper Agammaglobulinemia Pediatrics 9:722-728 Commentary Landmark Paper Nouvelle anomalie leucocytaire de caract6re constitutionnel familial [New Leukocyte Abnormality: Constitutional and Familial] Revue d'Hdmatologie 7:362-366 Commentary Landmark Paper Translation Splenic Studies. 1. Susceptibility to Infection after Splenectomy Performed in Infancy Annals of Surgery 136:239-242 Commentary Landmark Paper Preleukemic Acute Human Leukemia Journal of the American Medical Association 152:1018-1028 Commentary Landmark Paper Histiocytosis X: Integration of Eosinophilic Granuloma of Bone, Letterer-Siwe Disease and Schuller-Christian Disease as Related Manifestations of a Single Nosologic Entity American Medical Association Archives of Pathology 56:84-102 Commentary Landmark Paper A Fatal Granulomatosis of Childhood: The Clinical Study of a New Syndrome Minnesota Medicine 40:309-312 Commentary Landmark Paper Leukemic Reticuloendotheliosis Blood 13:609-629 Commentary Landmark Paper A Sarcoma Involving the Jaws in African Children British Journal of Surgery 46:218-223 Commentary Landmark Paper Experimental Nutritional Folate Deficiency in Man Transactions of the Association of American Physicians 75:307-320 Commentary Landmark Paper Inherited Antithrombin Deficiency Causing Thrombophilia Thrombosis et Diathesis Haemorrhagica 13:516-530 Commentary Landmark Paper An Inherited Abnormality of Neutrophil Adhesion New England Journal of Medicine 302:1163-1169 Commentary Landmark Paper Resistance to Activated Protein C as a Basis for Venous Thrombosis New England Journal of Medicine 330:517-522 Commentary Landmark Paper Section 2 Insights Into the Pathophysiology of Hematologic Disorders Observations of the Etiologic Relationship of Achylia Gastrica to Pernicious Anemia: The Effect of Administration to Patients with Pernicious Anemia of the Contents of Normal Human Stomach after Ingestion of Beef Muscle American Journal of the Medical Sciences 178:748-763 Commentary Landmark Paper Chronic Hemolytic Anemia with Paroxysmal Nocturnal Hemoglobinuria. A Study of the Mechanism of Hemolysis in Relation to Acid-Base Equilibrium New England Journal of Medicine 217:915-917 Commentary Landmark Paper Absorption and Excretion of Iron Lancet 2:680-684 Commentary Landmark Paper The Role of Isoimmunization in the Pathogenesis of Erythroblastosis Fetalis American Journal of Obstetrics and Gynecology 42:925-937 Commentary Landmark Paper Hemolytic Icterus (Acholuric Jaundice) Congenital and Acquired Lancet 1:812-814 Commentary Landmark Paper Sickle Cell Anemia, a Molecular Disease Science 110:543-548 Commentary Landmark Paper Studies on the Mechanism of Erythropoietic Stimulation in Parabiotic Rats during Hypoxia Blood 5:372-380 Commentary Landmark Paper Demonstration of a Thrombocytopenic Factor in the Blood of Patients with Thrombocytopenic Purpura Journal of Laboratory and Clinical Medicine 39:1-10 Commentary Landmark Paper Pr6sence d'une leuco-agglutine dans le s6rum d'un cas d' agranulocytose chronique [The Presence of a Leuko-Agglutinin in the Serum of a Case of Chronic Agranulocytosis] Comptes Rendus des Sdances de la Soci~t~ de Biologie et de ses Filiales 149:1539-1541 Commentary Landmark Paper Translation Humoral Regulation of Red Cell Production Blood 8:349-387 Commentary Landmark Paper The Hemolytic Effect of Primaquine. 1. The Localization of the Drug-Induced Hemolytic Defect in Primaquine-Sensitive Individuals Journal of Laboratory and Clinical Medicine 43:303-309 Commentary Landmark Paper A Minute Chromosome in Human Chronic Granulocytic Leukemia Science 132:1497-1497 Commentary Landmark Paper The Normal Human Female as a Mosaic of X-Chromosome Activity: Studies Using the Gene for G-6-PD-Deficiency as a Marker Proceedings of the National Academy of Sciences 48:9-16 Commentary Landmark Paper Waterfall Sequence for Intrinsic Blood Clotting Science 145:1310-1311 Commentary Landmark Paper An Enzyme Cascade in the Blood Clotting Mechanism, and Its Function as a Biochemical Amplifier Nature 202:498--499 Commentary Landmark Paper A New Consistent Abnormality in Chronic Myelogenous Leukemia Identified by Quinacrine Fluorescence and Giemsa Staining Nature 243:290-293 Commentary Landmark Paper Clinical Importance of Lymphoblasts with T Markers in Childhood Acute Leukemia New England Journal of Medicine 92:828-832 Commentary Landmark Paper Detection and Isolation of Type C Retrovirus Particles from Fresh and Cultured Lymphocytes of a Patient with Cutaneous T-Cell Lymphoma Proceedings of the National Academy of Sciences 77:7415-7419 Commentary Landmark Paper Helicobacter Pylori-Associated Gastritis and Primary B-Cell Gastric Lymphoma Lancet 338:1175-1176 Commentary Landmark Paper Section 3 Advances in Treatment of Hematologic Disease A New and Greatly Simplified Method of Blood Transfusion Medical Record 87:141-142 Commentary Landmark Paper Treatment of Pernicious Anemia by a Special Diet Journal of the American Medical Association 87:470--476 Commentary Landmark Paper Hemophilia: Some Properties of Substance Obtained from Normal Human Plasma Effective in Accelerating Coagulation of Hemophilic Blood Journal of Clinical Investigation 16:113-124 Commentary Landmark Paper A Preparation from Spoiled Sweet Clover (3,Y-Methylene-Bis-(4-Hydroxycoumarin)) Proceedings of the Staff Meetings of the Mayo Clinic 16:388-395 Commentary Landmark Paper Nitrogen Mustard Therapy: The Use of Methyl-Bis(13-Chlorethyl) Amine Hydrochloride and Tris(13-Chlorethyl) Amine Hydrochloride for Hodgkin's Disease, Lymphosarcoma, Leukemia and Certain Allied and Miscellaneous Disorders Journal of the American Medical Association 132:126--132 Commentary Landmark Paper Temporary Remissions in Acute Leukemia in Children Produced by Folic Acid Antagonist 4-Aminopteroyl-Glutamic Acid (Aminopterin) New England Journal of Medicine 238:787-793 Commentary Landmark Paper ACTH- and Cortisone-Induced Regressions of Lymphoid Tumors in Man. A Preliminary Report Cancer 2:943-945 Commentary Landmark Paper Erythroblastosis Fetalis. VII. Treatment with Exchange Transfusion New England Journal of Medicine 244:39-49 Commentary Landmark Paper The Treatment of Patients Suffering from Early Myocardial Infarction with Massive and Prolonged Streptokinase Therapy Transactions of the Association of American Physicians 71:287-296 Commentary Landmark Paper The Radical Radiotherapy of Regionally Localized Hodgkin's Disease Radiology 78:553-561 Commentary Landmark Paper Quadruple Combination Therapy (VAMP) for Acute Lymphocytic Leukemia of Childhood Proceedings of the American Association for Cancer Research 5:20 Commentary Landmark Paper Prevention of Rh Immunization Journal of the American Medical Association 199:390-394 Commentary Landmark Paper Impaired Platelet-Connective Tissue Reaction in Man after Aspirin Ingestion Lancet 2:495-497 Commentary Landmark Paper Immunological Reconstitution of Sex-Linked Lymphopenic Deficiency Lancet 2:1366-1369 Commentary Landmark Paper Combination Chemotherapy in the Treatment of Advanced Hodgkin's Disease Annals of lnternal Medicine 73:881-895 Commentary Landmark Paper Central Nervous System Therapy and Combination Chemotherapy of Childhood Lymphocytic Leukemia Blood 37:272-281 Commentary Landmark Paper Cytosine Arabinoside and Daunorubicin Therapy in Acute Nonlymphocytic Leukemia Cancer Chemotherapy Reports 52:485-488 Commentary Landmark Paper Treatment of Aplastic Anaemia by Antilymphocyte Globulin with and without Allogeneic Bone-Marrow Infusions Lancet 2:1145-1148 Commentary Landmark Paper One Hundred Patients with Acute Leukemia Treated by Chemotherapy, Total Body Irradiation, and Allogeneic Bone Marrow Transplantation Blood 49:511-533 Commentary Landmark Paper Antileukemic Effect of Chronic Graft Versus Host Disease New England Journal of Medicine 304:1529-1533 Commentary Landmark PaperAAlpha Interferon for Induction of Remission in Hairy Cell Leukemia New Eng land Journal of Medicine 310:15-18 Commentary Landmark Paper Use of All-Trans Retinoic Acid in the Treatment of Acute Promyelocytic Leukemia Blood 72:567-572 Commentary Landmark Paper Use of Monoclonal Antibody Directed against the Platelet Glycoprotein Ilb/Illa Receptor in High-Risk Coronary Angioplasty New England Journal of Medicine 330:956-961 Commentary Landmark Paper Section 4 Diagnostic or Clinical Laboratory Innovations Ober Agglutinationserscheinungen normalen menschlichen B lutes [On the Agglutination of Normal Human Blood] Wiener Klinische Wochenschrift 14:1132-1134 Commentary Landmark Paper Translation The Relation of Blood Platelets to Hemorrhagic Disease: Description of a Method for Determining the Bleeding Time and the Coagulation Time and Report of Three Cases of Hemorrhagic Disease Relieved by Transfusion Journal of the American Medical Association 55:1185-1192 Commentary Landmark Paper The Determination of the Length of Life of Transfused Blood Corpuscles in Man Journal of Experimental Medicine 29:267-281 Commentary Landmark Paper Reticulosis-Increased Percentage in the Peripheral Blood Journal of Laboratory andClinical Medicine 8:11-18 Commentary Landmark Paper Die intravitale Untersuchungsmethodik des Knochenmarks [The Intravital Research Methodology of the Marrow of a Bone] Folia Haematologica 38:233-240 Commentary Landmark Paper Translation Anemia: Classification and Treatment on the Basis of Differences in the Average Volume and Hemoglobin Content of Red Corpuscles Archives of lnternal Medicine 54:256-280 Commentary Landmark Paper A Study of the Coagulation Defect in Hemophilia and in Jaundice American Journal of the Medical Sciences 190:501-511 Commentary Landmark Paper A New Test for the Detection of Weak and "Incomplete" Rh Agglutinins British Journal of Experimental Pathology 26:255-266 Commentary Landmark Paper Morphology and Enumeration of Human Blood Platelets Journal of Applied Physiology 3:365-377 Commentary Landmark Paper Effect of Antihemophilic Factor on One-Stage Clotting Tests: A Presumptive Test for Hemophilia and Simple One-Stage Antihemophilic Factor Assay Procedures Journal of Laboratory and Clinical Medicine 41:637-647 Commentary Landmark Paper High Speed Automatic Blood Cell Counter and Cell Size Analyzer Proceedings of the National Electronics Conference 12:1034-1040 Commentary Landmark Paper Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells Radiation Research 14:213-222 Commentary Landmark Paper Aggregation of Blood Platelets by Adenosine Diphosphate and Its Reversal Nature 194:927-929 Commentary Landmark Paper The Chemotactic Effect of Mixtures of Antibody and Antigen on Polymorphonuclear Leukocytes Journal of Experimental Medicine 115:453-457 Commentary Landmark Paper Separation and Collection of Leukocytes Cancer Research 25:1516-1520 Commentary Landmark Paper The Cloning of Normal "Mast" Cells in Tissue Cultures Journal of Cellular and Comparative Physiology 66:319-324 Commentary Landmark Paper The Growth of Mouse Bone Marrow Cells In Vitro Australian Journal of Experimental Biology and Medical Science 44:287-289 Commentary Landmark Paper Detection of the Sickle Gene in the Human Fetus: Potential for Intrauterine Diagnosis of Sickle Cell Anemia New England Journal of Medicine 287:1-5 Commentary Landmark Paper Appendix Figure 1 Charles Mayo Depicts His Technique of Splenectomy 2 Demonstration of In Vitro Sickle Cell Formation in a Heterozygote 3 Deformation of the Skull by Excessive Erythropoiesis in a Patient of Cooley 4 Introduction of the Hematocrit Tube to Measure Packed Red Cell Volume 5 Application of Ashby Technique to Measurement of Red Cell Life-Span 6 Depiction of Siderocytes and Sideroblasts 7 Correlation of Red Cell Shape Alterations and Vascular Lesions in Microangiopathic Hemolytic Anemia 8 Mechanism of Exertional Hemoglobinuria 9 Polycythemia Resulting from an Inherited Abnormality of Hemoglobin 10 Mechanism for Premature Removal of Antibody-Coated Red Cells by the Mononuclear Phagocyte System 11 Use of Radioactive Iron to Study the Mechanism of Anemia in Man 12 Recombinant Human Erythropoietin Corrects the Anemia of End-Stage Renal Disease 13 Early Evidence for the Therapeutic Utility of Antihemophilic Globulin 14 Early Evidence for the Efficacy of Streptokinase to Lyse Clots 15 Homozygous Pelger-Hust Anomaly of Human Leukocytes 16 Early Depiction of "Fibrin Emboli" with Disseminated Intravascular Coagulation from Placenta Abruption 17 Introduction of Plastic Bags for Collection and Administration of Platelets for Transfusion 18 Depiction of Monstrous Granules in Human Leukocytes by Higashi 19 Purpura Fulminans Treated with Anticoagulation 20 Electron Micrograph of Viral Particles in Burkitt Lymphoma Cells 21 Description of Degradation Products of Fibrinogen Exposed to Plasmin 22 Characteristic Course of Heparin-Induced Thrombocytopenia 23 Depiction of the Giant Cell Characteristic of Hodgkin's Disease by Dorothy Reed 24 Salutary Effect of The "R6ntgen Ray" In The Treatment of Pseudoleukemia (Hodgkin Disease) 25 Introduction of Zonal Electrophoresis for Separation of Serum Proteins 26 Cytological Identification of Radiation Chimeras after Homologous Marrow Transplantation 27 Metaphase of Early Patient Carrying The Philadelphia Chromosome 28 Characteristic Depiction of The Hyperviscosity Syndrome 29 Introduction of a Method to Determine The Monoclonal Origin of Tumors 30 The Early Efficacy of Vamp in the Treatment of Childhood Lymphocytic Leukemia 31 Arabinosyl Cytosine (Cytarabine) in the Treatment of Acute Myelogenous Leukemia Bibliography: Articles Cited in Commentaries Sources Used in Preparation of Commentaries Author Index Subject Index

Quotes and reviews

"Great care has been shown by Lichtman and his colleagues. They should be commended for assembling these papers, which reflect closely so many of the important milestones in this fascinating discipline. A book to treasure and browse through to relieve the tensions of the working day." (J.Parker, British Journal of Haematology, 2001)

"This book...merits the attention of all hematologists who want to know the origin of their speciality."
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