* Critically reviews and evaluates all the important genetic and molecular and cellular biological data on the individual myelin genes/proteins
* Details the structural and functional biology of myelin, including a look at the relationship between neuronal damage and myelin damage as seen in multiple sclerosis
* Includes forward-looking section on potential therapeutic interventions in myelin diseases
With the completion of the "Human Genome Project" and the cloning and complete molecular description of the known myelin genes, the stage has been set for a detailed understanding of the biology of myelin, the disease processes affecting myelin and the potential for myelin repair and regeneration. Myelin Biology and Disorders brings together in one place, the recent advances in molecular and cellular biology along with visual data from MRI, confocal microscopy and high voltage EM techniques to provide new insights into disease mechanisms. This book represents a unique research reference on myelin biology and will serve as the definitive resource for both the professional clinical and basic scientist.
Neurologists, neurobiologists, and cell biologists.
Myelin Biology and Disorders, Two-Volume Set, 1st Edition
Section I: Diseases of Myelin
Leukodystrophies: Overview and Classification
Multiple Sclerosis: Classification and Overview
Genetic Susceptibility and Epidemiology
Cellular Damage and Repair in MS
MRI Visualization of MS
Multiple Sclerosis (General Clinical and Trials)
Guillain Barre Syndrome
Infectious Demyelinating Diseases
Ischemic White Matter Damage
Protein Misfolding as a Disease Determinant
Section II: Animals Models of Human Disease
Experimental Allergic Encephalomyelitis
Experimental Models of Virus Induced Demyelination
Model's of Krabbe's Disease
Model's of Alexander's Disease
Model's of Pelizeaus Merzbacher Disease
Models of Charcot-Marie-Tooth Disease
Section III: The Myelin Genes and Products
Myelin Basic Protein Gene
Proteolipid Protein Gene
Myelin Associated Glycoprotein Gene
Myelin Oligodendrocyte Glycoprotein Gene
Cyclic Nucleotide Phosophohydrolase Gene
P0 Protein Gene
PMP 22 Gene
The Claudin 11 Gene
The Neurexin Gene
The Connexin 32 Gene
The Integrin Genes
The Periaxin Gene
The QK1 Gene
Section IV: Glial Cell Development
Neural Cell Specification During Development
Progenitor Cells of the Adult Human White Matter
Schwann Cell Development
Olfactory Ensheathing Cells
Section V: Glial Cell and Myelin Functional Biology
Structure of the Myelinated Axon
Cell Biology of Myelin Assembly
The Transport and Assembly of Myelin Lipids
Functional Organization of the Nodes of Ranvier
Electrophysiologic Consequences of Myelination
Remyelination Through Engraftment
Remyelination by Endogenous Glia
Quotes and reviews
"Myelin Biology and Disorders, an extraordinary compilation of knowledge about myelin and myelin diseases, benefits from the intrinsic interest and importance of the topic no less than from the hard work of its contributing authors. ...Myelin Biology and Disorders represents a bravura achievement for all concerned and, now, a standard for the field."
--THE NEW ENGLAND JOURNAL OF MEDICINE(October 21, 2004)
"...a splendid book, an important addition to any serious clinical neuroscience bookshelf, and of lasting value: it is an outstanding achievement on the part of the Editor and the publisher."
"...no medical library or institution with a neuroscience research program can afford to be without a copy of this treatise. Lazzarini and his five section editors are to be applauded for overseeing the production of such a well-illustrated and thorough work on this set of major debilitating diseases. There is also an excellent historical preface that recounts the work of the remarkable set of early researchers whose splendid work in the late 19th and early 20th centuries founded this important field of research."
--Lloyd Davidson, Life Sciences Librarian, Head, Access Services and Kaplan Humanities Fellow, Northwestern University Seeley G. Mudd Library for Science and Engineering, E-STREAMS Vol 7 No 11, November 2004)
"Under the baton of Robert Lazzarini, five distinguished editors have assembled a comprehensive treatise covering the origin and neurobiology of myelin-forming cells, the assembly of the myelin sheath and its often unforgiving diseases."
--Monique Dubois-Dalcq, MD, Department of Neuroscience, The Pasteur Institute, Paris, France
"This book comprises comprehensive, thoughtfully edited, uniformly first-rate chapters on myelination. It is the definitive work in the field."
--David R. Colman. Ph.D., Director, The Montreal Neurological Institute
"The two volumes on Glial Cell and Myelin Functional Biology serve as an impressive platform to showcase the rich literature on oligodendrocytes and Schwann cells in development and disease...The current and comprehensive style will make this book a standard for the field."
--Moses V. Chao, Molecular Neurobiology Program,
Skirball Institute of Biomolecular Medicine,
New York University School of Medicine, New York City, U.S.A.