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The 40th volume of Methods in Microbiology focuses on microbial synthetic biology.Synthetic biology is a rapidly growing discipline that builds on well-established princi… Read more
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Series Page
Contributors
Preface
Chapter 1. Computational Intelligence in the Design of Synthetic Microbial Genetic Systems
Abstract
1 Introduction
2 Computational Infrastructure for Synthetic Biology
3 Computational Intelligence
4 Discussion
References
Chapter 2. Constraints in the Design of the Synthetic Bacterial Chassis
Abstract
1 Introduction
2 Top-Down Versus Bottom-Up Framing
3 An Unlimited List of Functions (Organised Starting from the Cell's Structure)
4 Perspective: The Fourth Dimension (When Time Measures and Shapes)
Acknowledgements
References
Chapter 3. Social Dimensions of Microbial Synthetic Biology
Abstract
1 Introduction: Making Space for a New Discussion
2 From Implications to Dimensions
3 From Speculation to Anticipation
4 From Public Acceptance to Public Good
5 From Regulation to Governance
Conclusions
References
Chapter 4. Bacillus subtilis: Model Gram-Positive Synthetic Biology Chassis
Abstract
1 Introduction
2 The B. subtilis Genome
3 Genome Management and Analysis of Gene Function
4 Analysis of the Transcriptome
5 Analysis of the Proteome
6 Analysis of the Metabolome
7 Parts, Devices, Systems and Applications
8 Computational Tools and Resources
Summary
References
Chapter 5. Engineering Microbial Biosensors
Abstract
1 Introduction
2 Areas of Application
3 Types of Biosensors
4 Reporters
5 Biosensors and Synthetic Biology
6 Transcription-Based Biosensors
7 Translation-Based Biosensors
8 Posttranslational Biosensors
9 In Vitro Biosensors
10 Modelling Biosensors
11 Outlook
References
Chapter 6. Noise and Stochasticity in Gene Expression: A Pathogenic Fate Determinant
Abstract
1 Introduction
2 Origins of Noise
3 Measuring Noise
4 Engineering Noise
5 Noise and Heterogeneity in Gene Expression
6 Bistable Expression of Pneumococcal Pili
7 Cooperative Virulence in Salmonella Enterica S. Typhimurium
Concluding Remarks
References
Chapter 7. Platforms for Genetic Design Automation
Abstract
1 Introduction
2 Standards
3 Repositories
4 GDA Software Tools
5 Discussion
Acknowledgements
References
Index
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