Development and Function of Myeloid Subsets

Development and Function of Myeloid Subsets, 1st Edition

Development and Function of Myeloid Subsets, 1st Edition,Kenneth  Murphy,Miriam Merad,ISBN9780124170285

Advances in Immunology

Murphy   &   Merad   

Academic Press




229 X 152

This series continually publishes cutting-edge reviews in the field of immunology.

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Key Features

  • Informs and updates on all the latest developments in the field
  • Contributions from leading authorities and industry experts


Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.


Immunologists and infectious disease specialists, cell biologists and hematologists.

Kenneth  Murphy

Affiliations and Expertise

Washington University School of Medecine, USA

Miriam Merad

Affiliations and Expertise

Icahn Medical Institute, New York, USA

Development and Function of Myeloid Subsets, 1st Edition

Series Page


Chapter One. Ontogeny and Functional Specialization of Dendritic Cells in Human and Mouse


1 Introduction

2 History of DC Identification and Characterization

3 Recent Advances in Mouse DC Immunobiology: Lessons from a Rodent

4 Recent Advances in Human DC Immunobiology

5 Humanized Mice

6 Matching Mice and Men

7 The Relationship of DCs to Monocytes and Macrophages

8 Next Steps Ahead

9 Disclosure Statement



Chapter Two. Dendritic Cell Migration Through the Lymphatic Vasculature to Lymph Nodes


1 Structure and Function of the Lymphatic Vasculature

2 DC Migration into Lymphatics and the Requirement for Specialized Lymphatic Capillaries

3 DC Mobilization to LNs: The Role of CCR7

4 DC Mobilization to LNs: The Machinery for Locomotion

5 Lymphangiogenesis and DC Trafficking During Inflammation

6 Concluding Remarks


Chapter Three. A Close Encounter of the Third Kind: Monocyte-Derived Cells


1 Dendritic Cell and Macrophages

2 Monocytes, the Mononuclear Phagocytes of the Blood Compartment

3 Monocytes, as Precursors of Tissue Mononuclear Phagocytes

4 Monocyte-Derived Cells in the Inflamed Peritoneum

5 Monocyte-Derived Cells in the Inflamed Brain

6 Monocyte-Derived Cells in the Intestine

7 Development of Monocyte-Derived Cells

8 Perspective



Chapter Four. Plasmacytoid Dendritic Cell Development


1 Background

2 Markers for pDC Identification

3 Cytokines Promoting pDC Development

4 Transcription Factors Determining pDC Development

5 Early Investigation of the Myeloid Versus Lymphoid Origin of pDC

6 Markers of pDC of Lymphoid Origin?

7 CDP and the Consensus Myeloid Pathway to pDC

8 Reassessment of the Lymphoid Pathway to pDC

9 Implications of RAG-1 Expression and IgH Gene Rearrangements in pDC

10 Extension of the CDP Definition to Include New pDC Precursors

11 A Different Non-pDC but pDC-Like Product of the Myeloid Pathway

12 Tracking pDC Development Using Cellular “Barcoding”

13 Some Conclusions


Chapter Five. Pathological Consequence of Misguided Dendritic Cell Differentiation in Histiocytic Diseases


1 The Mononuclear Phagocyte System

2 The DC Lineage

3 Origin and Regulation of DC Differentiation

4 DC Heterogeneity

5 Batf–IRF8–ID2-Dependent DC Lineage

6 Batf3–ID2–IRF8-Independent DC Lineage

7 Monocyte-Derived DCs and Inflammatory DCs

8 The LC Exception

9 The Human DC Lineage

10 Human Histiocytoses as a Result of Dysregulated Differentiation of the Human Myeloid Compartment

11 Conclusion and Perspective



Chapter Six. Macrophage Activation and Polarization as an Adaptive Component of Innate Immunity


1 Introduction

2 Activation, Priming, and Tolerance as Adaptive Responses of Macrophages (Fig. 6.1)

3 Polarized Activation

4 Molecular Mechanisms Underlying Macrophage Polarization

5 Epigenetic Regulation of Macrophage Polarization

6 Posttanscriptional Regulation in Macrophage Activation and Polarization

7 Concluding Remarks



Chapter Seven. Terminal Differentiation of Dendritic Cells


1 Introduction

2 Dendritic Cell Subsets

3 Transcriptional Regulation of Early DC Development: Cellular Differentiation and Some of the Key Regulatory Molecules

4 Transcriptional Regulation of Late DC Development at Steady State

5 Alternative DC Generation: Emergency Hematopoiesis

6 Perspectives



Chapter Eight. Diversity of Pathogen Sensors in Dendritic Cells


1 Introduction

2 Diversity of Pathogen Sensors in DCs

3 Interactions and Effectors

4 Perspectives



Chapter Nine. Transcriptional Control of Dendritic Cell Development


1 Dendritic Cells Comprise Functionally Heterogeneous Subsets

2 DC Development

3 ZBTB46 and CDCS

4 Ongoing Issues in DC Development



Chapter Ten. Transcriptional Control of Macrophage Identity, Self-Renewal, and Function


1 Creating Macrophage Identity

2 Controlling Macrophage Numbers and Proliferation

3 Transcriptional Control of Macrophage Specialization and Functional Activation States

4 Concluding Remarks




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