Volume 502: Protein Engineering for Therapeutics, Part A, 1st Edition

Key Features

Description

This volume of Methods in Enzymology looks at Protein Engineering for Therapeutics. The chapters provide an invaluable resource for academics, researchers and students alike. With an international board of authors, this volume is split into sections that cover subjects such as Antibodies, Protein conjugates, Peptides, Enzymes and Scaffolds

Protein Engineering for Therapeutics, Part A, 1st Edition

1. Simplified Synthetic Antibody Libraries

Saravanan Rajan and Sachdev S. Sidhu

2. Generation of Dual Variable Domain Immunoglobulin Molecules for Dual-specific Targeting

Jijie Gu and Tariq Ghayur

3. Discovery of internalizing antibodies to tumor antigens from phage libraries

Yu Zhou and James D Marks

4. Optimizing properties of anti-receptor antibodies using kinetic computational models and experiments

Brian D. Harms, Jeffrey D. Kearns, Stephen V. Su, Neeraj Kohli, Ulrik B. Nielsen and Birgit Schoeberl

5. Cell-specific siRNA delivery by peptides and antibodies

Sang-Kyung Lee, Alyssa Siefert, Jagadish Beloor, Tarek M Fahmy and Priti Kumar

6. Conjugation of Anticancer Drugs Through Endogenous Monoclonal Antibody Cysteine Residues

Robert P. Lyon*, David L. Meyer, Jocelyn R. Setter, and Peter D. Senter

7. Building and characterizing antibody-targeted lipidic nanotherapeutics

Dmitri B. Kirpotin, Charles O. Noble, Mark E. Hayes, Zhaohua Huang, Tad Kornaga, Yu Zhou, Ulrik B. Nielsen, James D. Marks, and Daryl C. Drummond

8. Cell-Targeting Fusion Constructs Containing Recombinant Gelonin

Mi-Ae Lyu; Yu (Joshua) Cao; Khalid A. Mohamedali; and Michael G. Rosenblum

9. Stapled Peptides for Intracellular Drug Targets

Gregory L. Verdine andGerard J. Hilinski

10. Mapping of vascular zip codes by phage display

Tambet Teesalu, Kazuki N. Sugahara & Erkki Ruoslahti

11. Engineering cyclic peptide toxins

Richard J. Clark and David J. Craik

12. Peptide Discovery using Bacterial Display and Flow Cytometry

Jennifer A. Getz, Tobias D. Schoep, Patrick S. Daugherty

13. Oral enzyme therapy for celiac sprue

Michael T Bethune1 and Chaitan Khosla

14. Rational Design and Evaluation of Mammalian Ribonuclease Cytotoxins

Jo E. Lomax, ChelcieH. Eller, and Ronald T. Raines

15. Engineering Reduced-Immunogenicity Enzymes for Amino Acid Depletion Therapy in Cancer

Jason R. Cantor, Vasiliki Panayiotou, Giulia Agnello, George Georgiou and Everett M. Stone

16. Designed Ankyrin Repeat Proteins (DARPins): From research to therapy

Rastislav Tamaskovic, Manuel Simon, Nikolas Stefan, Martin Schwill and Andreas Plückthun

17. Target-binding proteins based on the tenth human fibronectin type III domain (¹⁰Fn3)

Shohei Koide, Akiko Koide, and Daša Lipovšek

18. Anticalins: small engineered binding proteins based on the lipocalin scaffold

Michaela Gebauer

19. T Cell Receptor Engineering

Jennifer D. Stone, Adam S. Chervin, David H. Aggen, David M. Kranz

20. Engineering Knottins as Novel Binding Agents

Sarah J. Moore and Jennifer R. Cochran

21. Re-Engineering Biopharmaceuticals for Targeted Delivery Across the Blood-Brain Barrier

William M. Pardridge and Ruben J. Boado

22. Practical Theoretic Guidance for the Design of Tumor Targeting Agents

K. Dane Wittrup, Greg M. Thurber, Michael M. Schmidt, John J. Rhoden

23. Fusions of elastin-like polypeptides to pharmaceutical proteins

Wafa Hassouneh, Sarah R Mac Ewan, Ashutosh Chilkoti

24. Engineering and Identifying Supercharged Proteins for Macromolecule Delivery into Mammalian Cells
    
    David B. Thompson, James J. Cronican, and David R. Liu