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Practical Biostatistics
 
 

Practical Biostatistics, 1st Edition

A Friendly Step-by-Step Approach for Evidence-based Medicine

 
Practical Biostatistics, 1st Edition,Mendel Suchmacher,Mauro Geller,ISBN9780124157941
 
 
 

  &      

Academic Press

9780124157941

9780124158573

248

229 X 152

A concise guide for the interpretation and writing of observational studies and clinical trials

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Key Features

* Customized presentation for biological investigators with examples taken from current clinical trials in multiple disciplines

* Clear and concise definitions and examples provide a pragmatic guide to bring clarity to the applications of statistics in improving human health

* Addresses the challenge of assimilation of mathematical concepts to better interpret literature, to build stronger studies, to present research effectively, and to improve communication with supporting biostatisticians

Description

Evidence-based medicine aims to apply the best available evidence gained from the scientific method to medical decision making. It is a practice that uses statistical analysis of scientific methods and outcomes to drive further experimentation and diagnosis. The profusion of evidence-based medicine in medical practice and clinical research has produced a need for life scientists and clinical researchers to assimilate biostatistics into their work to meet efficacy and practical standards. Practical Biostatistics provides researchers, medical professionals, and students with a friendly, practical guide to biostatistics. With a detailed outline of implementation steps complemented by a review of important topics, this book can be used as a quick reference or a hands-on guide to effectively incorporate biostatistics in clinical trials.

Readership

Investigators and clinicians involved in genetics, genomics, immunology, virology, microbiology, cell biology, pharmacology, and biomedical research; post-doctoral fellows and graduate researchers; physicians who need to make evidence-based clinical decisions; physicians and medical students who consult medical literature which demands knowledge on biostatistics; instructors and trainees in national and international technical clinician and degree programs

Mendel Suchmacher

* Board Certification in Internal Medicine and Hematology-Hemotherapy * Post-graduation in Pharmaceutical Medicine (Universidade Federal do Estado de Sao Paulo) * Clinical Research Dpt. (Gross Pharmaceuticals) * Member of the American College of Physicians * Professor of Clinical Immunology - Carlos Chagas Institute of Medical Post-graduation (Rio de Janeiro) - Brazil * Professor of Microbiology and Immunology at Teresopolis University Medical School (Rio de Janeiro State) * Research Fellow - Fundacao Educacional Serra dos Orgaos (Rio de Janeiro)

Affiliations and Expertise

Gross Pharmaceuticals, Rio de Janeiro, Brazil

Mauro Geller

* Professor & Chairman of Immunology & Microbiology - Teresópolis Medical School (Centro Universitário Serra dos Órgãos - UNIFESO. Rio de Janeiro, Brazil) * Professor & Coordinator of the Genodermatoses Sector of the Clinical Genetics Service (Instituto de Puericultura e Pediatria Martagão Gesteira - UFRJ. Rio de Janeiro, Brazil) * Professor and Chairman of Clinical Immunology (Instituto de Pós-Graduação Médica Carlos Chagas. Rio de Janeiro, Brazil) * Member of the clinical staff of Hospital Israelita Albert Einstein (HIAE - São Paulo, Brasil) Mauro Geller MD, PhD holds an MD degree from Teresopolis University Medical School, a PhD in Clinical Medicine from Universidade Federal do Rio de Janeiro, and a Post-PhD in Immunogentics from Harvard University. He has extensive experience in the area of clinical immunology, especially in the areas of clinical medicine, tumoral immunology, genetics and immunodiagnostics. Dr. Geller is a founding member of the Brazilian National Neurofibromatosis Center (Centro Nacional de Neurofibromatose - CNNF), where he also serves as Scientific Director. He is a two-time recipient of the Moção de Louvor of the Assembléia Legislativa do Estado do Rio de Janeiro; in 1994 he received the Título de Benmerito do Estado do Rio de Janeiro, and he has received several awards of recognition from UNIFESO, from both the faculty and students. In 1996, he was awarded the Public Service Award from the National Neurofibromatosis Foundation and in 1997 he was named Honorary Chairperson of the same institution. IN 2006, he received the Prêmio de Incentivo Científico Hilton souchois from the Brazilian Society of Odontology. He also has extensive experience with research in the areas of immunology, microbiology and genetics, as well as with clinical research, and has published 137 papers, 8 book chapters, and 4 books. He also serves as an ad hoc advisor to the Brazilian National Institute of Health (ANVISA).

Affiliations and Expertise

Clinical Genetics (Phacomatosis Dpt.), Universidade Federal do Rio de Janeiro, Brazil

Practical Biostatistics, 1st Edition

PART 1 - STUDY TYPE DETERMINATION
1. Epidemiological studies
2. Analytical studies
3. Summary


PART 2 - OBSERVATIONAL STUDIES
4. Determination of association strength between an exposure factor and an event in observational studies
5. Increasing accuracy in observational studies


PART 3 - STEP-BY-STEP BIOSTATISTICS OF A CLINICAL TRIAL
6. STEP 1: Investigator's hypothesis and expression of its corresponding outcome
7. STEP 2: n estimation and n assessment of a published trial
8. STEP 3: Organization of variables and endpoints
9. STEP 4: Measures for results expression of a clinical trial
10. STEP 5: Determination of normality or non-normality of data distribution
11. STEP 6: Hypothesis testing
12. STEP 7: Correlating sample data with the general population - 95% confidence Interval


PART 4 - ADDITIONAL CONCEPTS IN BIOSTATISTICS
13. Individual and collective benefit and risk indexes inferable from intervention cohort studies
14. Statistical assessment of diagnostic tests for the clinic
15. Systematic reviews and meta-analyses
16. Correlation and regression
17. Per protocol analysis and intention to treat analysis


Self-evaluation
Annotated answers
Microsoft Excel 2010 Basics
References
Glossary
Index

Quotes and reviews

"With a detailed outline of implementation steps complemented by a review of important topics, this book can be used as a quick reference or a hands-on guide to effectively incorporate biostatistics in clinical trials."--Doody.com, April 24, 2013
"Practical Biostatistics is destined to be a companion book for health professionals and graduation students who face the challenge of assimilating concepts on statistics."

Mauri Carakushansky, MD
Pediatric Endocrinologist - Nemours Children's Clinic Orlando
, Assistant Professor of Pediatrics - Florida State University, Assistant Professor of Pediatrics - University of Central Florida

"This work by Dr. Suchmacher and Dr. Geller is bound to become a classic and should be readily available on the desk, shelf and on line."

Salin Dahlben, Harvard University, Clinical Assistant Professor in Psychiatry, Tufts University

"Dr. Suchmacher and Dr. Geller are experienced researchers and writers in the clinical research field, who were able to fathom the often confusing realm of Statistics applied to biological sciences, and to come back with a pragmatic study proposal for interested medical students and healthcare professionals […] In my opinion, 'Practical Biostatistics' will undoubtedly be welcomed as one of the books designed to bring medical students and healthcare professionals alike, closer to a better understanding of this inescapable issue."

Spyros G.E. Mezitis, Assistant Professor of Clinical Medicine, The New York Presbyterian Hospital Weill, Cornell Medical Center

"I believe the result of [Drs. Suchmacher and Geller’s] efforts will prove useful for many medical students and researchers, who must thrive in an era when Biostatistics is destined to be an ever present matter."

Allan E. Rubenstein, Clinical Professor of Neurology, The Stephen D. Hassenfeld Children's Center for Cancer and Blood Disorders, Langone Medical Center, School of Medicine, New York University

Practical Biostatistics is destined to be a companion book for health professionals and graduation students who face the challenge of assimilating concepts on statistics."

Mauri Carakushansky, MD, Pediatric Endocrinologist - Nemours Children's Clinic Orlando, Assistant Professor of Pediatrics - Florida State University, Assistant Professor of Pediatrics - University of Central Florida

 
 
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