Accurate Results in the Clinical Laboratory

Accurate Results in the Clinical Laboratory, 1st Edition

A Guide to Error Detection and Correction

Accurate Results in the Clinical Laboratory, 1st Edition,Amitava Dasgupta,Jorge Sepulveda,ISBN9780124157835

Dasgupta   &   Sepulveda   





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Practical, easy-to-use guide to interference issues across all types of clinical laboratory tests- for both clinicians and clinical laboratory scientists.

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Key Features

  • Named to Doody’s Core Titles 2013, a collection development tool for health sciences libraries of all sizes, by Doody Enterprises
  • Practical information for both clinicians and laboratory scientists, presented in the form of tables and charts for easy reference
  • Focus on range and sources of interferences rather than details of toxicologic mechanisms which are well covered in toxicology textbooks
  • Covers interferences across endocrine, oncology, hematology, immunohistochemistry, immunology, serology, microbiology, and molecular testing


This practical, easy-to-use guide, named to Doody’s Core Titles 2013, addresses interference issues in all laboratory tests, including patient epigenetics, process of specimen collection, enzymes, biomarkers. Clinicians and laboratory scientists can therefore rely on one reference which speaks to both their needs of accurate specimen analysis and optimal patient care.

Erroneous hospital and pathology laboratory results can be confusing and problematic, especially in acute care situations. While some factors creating interference, can be identified in the laboratory, detecting many others is often dependent on clinical details unavailable to the laboratory scientists or pathologists. Therefore, clinicians must become proficient in identifying such erroneous reports, and working with pathologists and laboratory scientists so that they can understand the source of such interferences, correct the results, and then decide what course of action must be followed for proper patient management.


Pathologists, clinical chemists, and toxicologists; practicing clinicians, fellows and residents in pathology, internal medicine, emergency medicine and family practice.

Amitava Dasgupta

Amitava Dasgupta received his PhD degree in Chemistry from the Stanford University and his fellowship training in Clinical Chemistry from the Laboratory Medicine Department of the University of Washington School of Medicine at Seattle. He is a tenured Full Professor of Pathology and Laboratory Medicine at the University of Texas Health Sciences Center located at the Texas Medical Center at Houston. Dr. Dasgupta has published 210 scientific papers, wrote many invited review articles, and edited, co-edited or wrote 15 books. He is on the Editorial Board of five major medical journals including American Journal of Clinical Pathology, Archives of Pathology and Laboratory Medicine, Therapeutic Drug Monitoring, Clinica Chimica Acta and Journal of Clinical Laboratory Analysis.

Affiliations and Expertise

Professor, Pathology and Laboratory Medicine, University of Texas Health Science Center, Houston, TX, USA

View additional works by Amitava Dasgupta

Jorge Sepulveda


Jorge Sepulveda received his M.D. from the University of Lisbon, Portugal, and his residency training in Laboratory Medicine and Ph.D. degree in Cell and Molecular Biology from Baylor College of Medicine, Houston, Texas. He is board certified by the American Board of Pathology in Clinical Pathology and Transfusion Medicine. He has published over 35 research articles, review papers and book chapters, and serves as Associate Editor for the Archives of Pathology and Laboratory Medicine. Dr. Sepulveda has broad experience in laboratory medicine as medical director of various clinical laboratories, including at the Houston and Philadelphia Veterans Affairs Medical Centers and at the University of Pittsburgh Presbyterian and Shadyside Hospitals, and currently serves as Associate Medical Director of the Clinical Laboratories at the Columbia University Medical Center Campus of New York-Presbyterian Hospital.

Affiliations and Expertise

Associate Professor and Associate Director of Laboratory Medicine, Department of Pathology and Cell Biology, Columbia University College of Physicians and Surgeons, New York, NY, USA

Accurate Results in the Clinical Laboratory, 1st Edition

Chapter 1. Variation, Errors, and Quality in the Clinical Laboratory

Jorge Sepulveda

Chapter 2. Effect of Age, Gender, Diet, Exercise and Ethnicity on Laboratory Test Results

Octavia M. Peck Palmer

Chapter 3. Effect of patient preparation, specimen collection, anticoagulants and preservatives on laboratory tests

Leland Baskin, Valerian Dias, Alex Chin, Amid Abdullah and Christopher Naugler

Chapter 4. Sample processing and specimen misidentification issues

Alison Woodworth and Amy L. Pyle

Chapter 5. Hemolysis, lipemia and high bilirubin: effect on laboratory tests

Steven C. Kazmierczak

Chapter 6. Immunoassay design and mechanism of interferences

Pradip Datta

Chapter 7. Effect of herbal remedies on clinical laboratory tests

Amitava Dasgupta

Chapter 8. Challenges in routine clinical chemistry: analysis of small molecules

Jorge Sepulveda

Chapter 9. Challenges in routine clinical chemistry: proteins and enzymes

Jorge Sepulveda

Chapter 10. Sources of inaccuracy in biochemical genetics analysis

Michael J. Bennett

Chapter 11. Challenges in endocrinology testing

Lindsay A. L. Bazydlo, Neil S. Harris and William E. Winter

Chapter 12. Pitfalls in tumor marker testing

Alyaa Al-Ibraheemi, Amitava Dasgupta, and Amer Wahed, M.D

Chapter 13. Issues of interferences in therapeutic drug monitoring

Gwendolyn A. McMillin, and Kamisha L. Johnson-Davis

Chapter 14. Limitations of drugs of abuse testing

Amitava Dasgupta

Chapter 15. Challenges in confirmation testing for drugs of abuse

Larry A. Broussard

Chapter 16. Alcohol determination using automated analyzers: limitations and pitfalls

Sheila Dawling

Chapter 17. Pre-analytical issues and interferences in transfusion medicine tests

Elena Nedelcu

Chapter 18. Critical issues in immunology and serology testing

Amer Wahed, Semyon Risin

Chapter 19. Sources of errors in hematology and coagulation testing

Andy Nguyen, Amer Wahed

Chapter 20. Challenges in Clinical Microbiology Testing

Laura Chandler

Chapter 21. Sources of errors in molecular testing

Laura Chandler

Chapter 22. Problems in Pharmacogenomics Testing

Dina N Greene, Cecily Vaughn, Elaine Lyon

Quotes and reviews

"Dasgupta and Sepulveda offer clinicians and laboratory scientists a guide to error detection and correction in the clinical laboratory that addresses sources of errors in analytical methods and sources of pre-analytical variation."--Reference and Research Book News, August 2013
"This is a very helpful book correlating nonanalytical measurement errors or disease states with anticipated effects on laboratory test results. This would be a must for the laboratory medicine resident who has to explain why results don't correlate with clinical disease."--Doody.com, August 9, 2013

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