Advances in Immunology

Advances in Immunology, 1st Edition

Advances in Immunology, 1st Edition,Frederick Alt,ISBN9780124105249

Advances in Immunology

F Alt   

Academic Press




229 X 152

This series continually publishes cutting-edge reviews in the field of immunology

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Key Features

  • Contributions from leading authorities
  • Informs and updates on all the latest developments in the field


Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.


Immunologists and infectious disease specialists, cell biologists and hematologists

Frederick Alt

Affiliations and Expertise

Howard Hughes Medical Institute Research Laboratories, The Children's Hospital, Boston, MA, USA

View additional works by Frederick W. Alt

Advances in Immunology, 1st Edition

Series Page


Chapter One. Mechanisms of Epigenetic Regulation of Leukemia Onset and Progression

1 Introduction

2 Aberrant DNA Methylation in Leukemia

3 Disruption of Histone-Modifying Complexes Polycomb and MLL in Leukemia

4 Other Epigenetic Writers, Erasers, and Readers

5 Novel Aspects and Technologies in Epigenetics: Implications for Leukemia

Chapter Two. Translocations in Normal B Cells and Cancers: Insights from New Technical Approaches

1 Mechanistic Elements that Generate Chromosomal Translocations

2 Novel High-Throughput Methods to Study Chromosomal Translocations

3 New Findings on Translocation Formation Obtained by HTGTS and TC-Seq

4 Landscape of Translocations in Cancers

5 Perspectives

Chapter Three. The Intestinal Microbiota in Chronic Liver Disease

1 Introduction

2 Role of the Intestinal Microbiota on Chronic Liver Diseases

3 Role of the Interactions Between the Innate Immune System and the Intestinal Microbiota on Chronic Liver Diseases

4 Probiotics and their Potential Role in Liver Disease Therapy

5 Conclusions

Chapter Four. Intracellular Pathogen Detection by RIG-I-Like Receptors

1 General Principles of the Antiviral Innate Immune Response

2 RLRs are RNA Sensors

3 RIG-I Activation and Receptor Proximal Signal Propagation

4 Regulatory Mechanisms of RIG-I Signaling

5 Conclusions and Future Directions


Contents of Recent Volumes

Quotes and reviews

"The series which all immunologists need." --The Pharmaceutical Journal

"Advances in Immunology must find itself among the most active volumes in the libraries of our universities and institutions." --Science

"Deserves a permanent place in biomedical libraries as an aid in research and in teaching." --Journal of Immunological Methods

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