Advances in Virus Research

Advances in Virus Research , 1st Edition

Advances in Virus Research , 1st Edition,Karl Maramorosch,Frederick Murphy,ISBN9780124081161

Advances in Virus Research

Maramorosch   &   Murphy   

Academic Press




229 X 152

This series continually publishes cutting-edge reviews written by experts in the field of virus research

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Key Features

  • Contributions from leading authorities
  • Informs and updates on all the latest developments in the field


Published since 1953, Advances in Virus Research covers a diverse range of in-depth reviews providing a valuable overview of the current field of virology.


Virologists, microbiologists and infectious diseases specialists

Karl Maramorosch

Professor Karl Maramorosch works at Rutgers University, New Brunswick, NJ, USA.

Affiliations and Expertise

Rutgers University, New Brunswick, NJ, USA

View additional works by Karl Maramorosch

Frederick Murphy

Frederick A. Murphy, DVM, PhD, is professor, Department of Pathology, University of Texas Medical Branch (UTMB), Galveston. He holds a BS and DVM from Cornell University and a PhD from the University of California, Davis (UC Davis). Formerly he was dean and distinguished professor, School of Veterinary Medicine, and distinguished professor, School of Medicine, UC Davis. Before that he served as director of the National Center for Infectious Diseases, and director of the Division of Viral and Rickettsial Diseases, Centers for Disease Control, Atlanta. He is a member of the Institute of Medicine of the U.S. National Academy of Sciences and is a member of the German National Academy of Sciences and the Belgian Royal Academy of Medicine. He holds an honorary Doctor of Medicine and Surgery from the University of Turku, Finland; an honorary Doctor of Science from the University of Guelph, Canada; an honorary Doctor of Veterinary Medicine from the University of London, United Kingdom; an honorary Doctor of Science from University College Dublin, Ireland; the Presidential Rank Award of the U.S. Government; the PennVet World Leadership Award from the University of Pennsylvania, and the Distinguished Microbiologist Award from the American College of Veterinary Microbiologists. At UTMB, he is a member of the Institute for Human Infections and Immunity, Center for Biodefense and Emerging Infectious Diseases, Galveston National Laboratory, and McLaughlin Endowment for Infection and Immunity. His professional interests include the pathology and epidemiology of highly pathogenic viruses/viral diseases: rabies and the rabies-like viruses, arboviruses, hemorrhagic fever viruses, and other neurotropic viruses. He has been a leader in advancing the concepts of “new and emerging infectious diseases” and “new and emerging zoonoses” and “the threat posed by bioterrorism.” Most recently, he has been working on Internet resources on the history of virology: “The Foundations of Virology” at http://www.utmb.edu/virusimages/.

Affiliations and Expertise

University of Texas Medical Branch, Galveston, TX, USA

View additional works by Frederick A. Murphy

Advances in Virus Research , 1st Edition

Series Page


In Memoriam

Aaron Shatkin (1934–2012)

Chapter One. Regulation of Retroviral Polyadenylation



1 Cellular Polyadenylation

2 Retroviral Long Terminal Repeats

3 Retroviruses with the Poly(A) Signal Located in the U3 Region

4 Retroviruses Encoding the Poly(A) Signal in the R Region

5 Conclusions



Chapter Two. Open Questions About Giant Viruses


1 Background

2 The Traditional View: Viruses Started Small, Got Bigger

3 Genome Reduction: A Neutral Ratchet Wheel Generating the Diversity of Large DNA Viruses

4 Speculation on the Nature of the Giant Virus Ancestor



Chapter Three. Assembly and Budding of Negative-Strand RNA Viruses


1 Introduction

2 Virion Structure: The Final Product

3 Steps in Assembly of Virus Budding Sites

4 Role of Membrane Microdomains in Assembly of Envelope Glycoproteins

5 Assembly of Viral Matrix Proteins

6 Selection of Nucleocapsids

7 Late Budding Functions and Virus Release

8 Back to the Beginning: How is Assembly Initiated?

9 Perspectives for the Future


Chapter Four. Arthropod-Borne Flaviviruses and RNA Interference: Seeking New Approaches for Antiviral Therapy


1 Introduction

2 The RNA Interference Mechanism and its Antiviral Effects

3 Arthropod-Borne Flaviviruses

4 RNAi and the Mosquito Vector

5 The Interplay Between Arthropod-Borne Flaviviruses and the Endogenous Host Cell RNAi Pathway

6 Conclusions and Challenges




Quotes and reviews

"A mandatory purchase for all types of comprehensive libraries, both public and university, as well as for those interested in or doing research in the field of virology." --Military Medicine

"This serial...is well known to virologists. It is a valuable aid in maintaining an overview of various facets of the rapidly expanding fields of virology...Timely, informative, and useful to the student, teacher, and research scientist." –American Scientist

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