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Neural Crest and Placodes
1st Edition, Volume 111 - February 3, 2015
Editor: Paul Trainor
Language: English
Hardback ISBN:9780124077591
9 7 8 - 0 - 1 2 - 4 0 7 7 5 9 - 1
eBook ISBN:9780124078901
9 7 8 - 0 - 1 2 - 4 0 7 8 9 0 - 1
Neural Crest and Placodes provides in-depth coverage of the topic, including information on their critical role in vertebrate development, evolution, and the way defects in th…Read more
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Neural Crest and Placodes provides in-depth coverage of the topic, including information on their critical role in vertebrate development, evolution, and the way defects in their development underlie a wide range of congenital disorders. It delves deep into advances made in our understanding of the mechanisms governing the formation, migration, and differentiation of these two cell populations, also discussing their integration during embryonic development.
The text highlights the application of fundamental knowledge in investigating the etiology and pathogenesis of congenital disorders and the ways the data applies to the field of regenerative medicine.
Written by leading experts in the field
Includes descriptions of the most recent advances in the field
Highlights the applications of this knowledge in investigating the etiology and pathogenesis of congenital disorders
Explores their usage in the field of regenerative medicine
Researchers in cell, developmental, and molecular biology; genetics.
Preface
Section A: Neural Crest Cells
Chapter One: Neural Crest Cell Evolution: How and When Did a Neural Crest Cell Become a Neural Crest Cell
3 Cardiac NCCs are Essential for Cardiac OFT Septation
4 Signaling Pathways in Cardiac NCC-Mediated Vascular Remodeling
5 Cardiac NCCs Contribution to the Cardiac Valves
6 Possible Roles for Cardiac NCCs in Myocardial Development
7 Possible Roles for Cardiac NCCs in the Development of the Cardiac Conduction Systems
8 Congenital Abnormalities Caused by Defective Cardiac NCC Development
9 Outstanding Questions
Chapter Seven: Molecular Control of the Neural Crest and Peripheral Nervous System Development
Abstract
1 Introduction
2 Neural Crest Specification
3 Migratory Patterns of Trunk Neural Crest
4 Molecular Regulators of Neural Crest Migration
5 Boundary Cap
6 Sensory Neurogenesis in the DRG
7 Neurotrophic Factors in Sensory Neuron Development
8 Gliogenesis in the PNS
9 Trophic Signaling Mechanisms During PNS Development
10 Conclusions
Acknowledgment
Section B: Placodes
Chapter Eight: Vertebrate Cranial Placodes as Evolutionary Innovations—The Ancestor's Tale
Abstract
1 Introduction
2 A Brief Primer on Metazoan Phylogeny
3 Vertebrates
4 The Tunicate–Vertebrate Clade
5 Chordates
6 Deuterostomes
7 Bilateria
8 Eumetazoa and Metazoa
9 Summary and Conclusions
Chapter Nine: Transcriptional Regulation of Cranial Sensory Placode Development
Abstract
1 Introduction
2 Induction and Specification of the Preplacodal Field
3 Breaking the PPE into Individual Placodes with Different Developmental Fates
4 Regulation of Cellular Differentiation
5 NB Zone, PPE, and Placode Genes Involved in Human Congenital Syndromes
6 Conclusions
Acknowledgments
Chapter Ten: Neural Crest and Placode Contributions to Olfactory Development
Abstract
1 Introduction
2 The OP Formation
3 The OE Development
4 The Adult OE Maintenance
5 The Multipotent Stem Cells in the LP
6 Contribution of NCDCs in the OM
7 The Limitation of Current Techniques and Future Perspectives
Conflict of Interests
Acknowledgments
Chapter Eleven: Epithelial Morphogenesis: The Mouse Eye as a Model System
Abstract
1 Introduction
2 Eye Morphogenesis
3 Dynamic Changes in the Actin Cytoskeleton Drive Morphogenesis
4 Shaping of the Optic Cup
5 Conclusions
Acknowledgments
Chapter Twelve: Developing and Regenerating a Sense of Taste
Abstract
1 How Are Taste Buds Patterned?
2 Regulation of Taste Cell Fate
3 How Can We Link Embryonic Development and Adult Taste Cell Renewal?
4 Is There a Specialized Taste Bud Stem Cell Population, or Are Extrinsic Signals Responsible for Defining which Cell Lineages Are Generated, and When?
5 Is Molecular Regulation of Taste Cell Renewal Analogous to That of Taste Bud Development?
Acknowledgments
Chapter Thirteen: Signaling in Tooth, Hair, and Mammary Placodes
Abstract
1 Introduction
2 Early Patterning and Morphogenesis of Skin Appendages
3 Perspectives
Acknowledgments
Chapter Fourteen: The Role of Foxi Family Transcription Factors in the Development of the Ear and Jaw
Abstract
1 The Anatomy and Embryonic Origins of the Inner, Middle, and Outer Ears
2 Forkhead Proteins as Transcription Factors and Pioneer Factors
3 The Role of Foxi Family Members in Inner Ear Development
4 The Role of Foxi Family Members in Middle Ear, Outer Ear, and Jaw Development
5 Conclusions
Chapter Fifteen: The Use of Human Pluripotent Stem Cells for the In Vitro Derivation of Cranial Placodes and Neural Crest Cells
Abstract
1 Introduction
2 Pluripotent Stem Cells
3 Derivation of NC Cells from hESC/hIPSC
4 Derivation of CP Cells from hESC/hIPSC
5 Conclusions
Index
No. of pages: 542
Language: English
Edition: 1
Volume: 111
Published: February 3, 2015
Imprint: Academic Press
Hardback ISBN: 9780124077591
eBook ISBN: 9780124078901
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Paul Trainor
Paul Trainor, PhD is an Investigator at the Stowers Institute for Medical Research in Kansas City, MO USA with over 20 years of experience working in the fields of developmental biology, neurobiology and craniofacial morphogenesis. He received his PhD from the University of Sydney, Australia under the tutelage of Dr Patrick Tam before undertaking post-doctoral training with Dr Robb Krumlauf at the National Institute for Medical Research in London, England. The current emphasis of Dr Trainor’s research centres on the role of neural crest cells in craniofacial evolution, development and disease. He seeks to understand the mechanisms that regulate neural crest cell patterning and apply this basic knowledge to decipher the etiology and pathogenesis of birth defects and potentially develop therapeutic avenues for their prevention. His laboratory studies neurocristopathies (disorders of neural crest cell development) such as Treacher Collins syndrome, Holoprosencephaly and Syngnathia as well as other neurocristopathy disorders such as Hirschsprung disease. Dr Trainor is currently vice-present of the Society for Craniofacial Genetics and Development.
Affiliations and expertise
Stowers Institute for Medical Research, Kansas City, KS, USA