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Cancer Theranostics
1st Edition - March 20, 2014
Editors: Xiaoyuan Chen, Stephen Wong
Language: English
Hardback ISBN:9780124077225
9 7 8 - 0 - 1 2 - 4 0 7 7 2 2 - 5
eBook ISBN:9780124078840
9 7 8 - 0 - 1 2 - 4 0 7 8 8 4 - 0
Aiding researchers seeking to eliminate multi-step procedures, reduce delays in treatment and ease patient care, Cancer Theranostics reviews, assesses, and makes pertinent…Read more
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Aiding researchers seeking to eliminate multi-step procedures, reduce delays in treatment and ease patient care, Cancer Theranostics reviews, assesses, and makes pertinent clinical recommendations on the integration of comprehensive in vitro diagnostics, in vivo molecular imaging, and individualized treatments towards the personalization of cancer treatment.
Cancer Theranostics describes the identification of novel biomarkers to advance molecular diagnostics of cancer. The book encompasses new molecular imaging probes and techniques for early detection of cancer, and describes molecular imaging-guided cancer therapy. Discussion also includes nanoplatforms incorporating both cancer imaging and therapeutic components, as well as clinical translation and future perspectives.
Supports elimination of multi-step approaches and reduces delays in treatments through combinatorial diagnosis and therapy
Fully assesses cancer theranostics across the emergent field, with discussion of biomarkers, molecular imaging, imaging guided therapy, nanotechnology, and personalized medicine
Content bridges laboratory, clinic, and biotechnology industries to advance biomedical science and improve patient management
Industry and academia working on drug discovery/development, pharmacology, personalized medicine, nanomedicine, medical imaging, imaging guided therapy, biomarkers, molecular pathology, proteomics, genomics, microarray chips, molecular biology.
Preface
Acknowledgments
About the Editors
List of Contributors
Part I: In Vitro Diagnostics
Chapter 1. Cancer Theranostics: An Introduction
Cancer Theranostics: A Definition
Theranostic Cancer Biomarkers
Molecular Imaging in Cancer Theranostics
Imaging-Guided Cancer Therapy
Theranostic Platforms
Challenges and Future Perspectives
References
Chapter 2. Genomics-Based Cancer Theranostics
Introduction
Next Generation Sequencing Technology for Genomics-Based Cancer Theranostics
Genomics Landscapes in Common Forms of Human Cancers
Functions of Key Signaling Pathways in Cancer
Integration of Genomic Screening for Cancer Theranostics
Acknowledgments
Glossary
Abbreviations
References
Chapter 3. Proteomics-Based Theranostics
Introduction
Mass Spectrometry Techniques Used for Proteomics Biomarker Discovery
Bioinformatics Analysis Pipeline for Proteomics Biomarker Discovery
Challenges in Proteomics Biomarker Discovery
Existing Single Biomarkers
Knowledge-Integrated Network Biomarker Discovery
Clinical Validation of Proteomics Biomarkers
Glossary
Abbreviations
References
Part II: Molecular Imaging
Chapter 4. Radionuclide Imaging of Cancer Therapy
Bone Scintigraphy
Thyroid Radioiodine Scintigraphy
Nonspecific Single-Photon Radiotracers
Positron Emission Tomography
Conclusion
References
Chapter 5. Near-Infrared Fluorescence Imaging Probes for Cancer Diagnosis and Treatment
Introduction
Antibody-Based NIR Probes
Peptide-Based NIR Probes
Aptamer-Based NIR Probes
Polymer-Based NIR Probes
Lipid-Based NIR Probes
Functional Quantum Dots
Functional Upconversion Nanoparticles
Clinical Applications and Perspectives
Conclusions
Acknowledgments
References
Chapter 6. Bioluminescence Imaging of Cancer Therapy
Introduction
Preclinical Bioluminescence Imaging for Monitoring Cancer Therapy
Therapeutic Evaluation in Rat
Conclusion
References
Chapter 7. Magnetic Resonance Imaging of Cancer Therapy
New Trends of Cancer Therapies
MR Imaging in Translational Cancer Therapy
Necrosis MR Imaging: A Potential Platform for Developing Cancer Theranostics
Acknowledgments
Abbreviations
References
Chapter 8. Ultrasound Imaging of Cancer Therapy
Introduction
Ultrasound Imaging Concepts
Assessment of Cancer Therapy
Conclusion
Acknowledgments
Abbreviations
Glossary
References
Chapter 9. Photoacoustic Imaging for Cancer Diagnosis and Therapy Guidance
Introduction
Operation Principle (Theory)
Photoacoustic Anatomical and Functional Imaging: Imaging Cancer with Endogenous Contrast
Photoacoustic Molecular Imaging: Imaging Cancer with Exogenous Contrast
Photoacoustic Image-Guided Cancer Therapies
Outlook
References
Part III: Imaging-Guided Therapy
Chapter 10. Multimodality Image-Guided Lung Intervention Systems
Introduction
Medical Imaging for Minimally Invasive Intervention
Interventional Device Tracking
Image-Guided Lung Intervention
Conclusion
Acronyms and Abbreviations
References
Chapter 11. Label-Free Molecular Vibrational Imaging for Cancer Diagnosis
Introduction
Diagnostic Imaging of Prostate Gland and Cavernous Nerves Using CARS
CARS for Differential Diagnosis of Human Lung Cancer
Suppression of Four-Wave Mixing in Multimode Fibers for Fiber-Delivered CARS Imaging
Conclusions and Future Directions
Acknowledgments
Acronyms and Abbreviations
References
Chapter 12. Multimodality Image-Guided Treatment
Introduction
Imaging Modalities in Clinical Cancer Practice
Locoregional Cancer Therapy in Clinical Practice
Image-Guided Therapy and Multimodality Image-Guided Treatment
Possibilities of Multimodality Image-Guided Treatment
Limitations of and Requirements for Successful Deployment of Multimodality Image-Guided Treatment
Conclusion
Acronyms and Abbreviations
References
Chapter 13. Medical Robotics for Cellular and Molecular Imaging
Overview
Confocal Endomicroscopy for Detection of Neoplasia
Challenges Faced by Confocal Endomicroscopy
Robotic Assistance and Computer-Aided Diagnosis
Future Work
References
Part IV: Theranostic Platforms
Chapter 14. Porphyrins for Imaging, Photodynamic Therapy, and Photothermal Therapy
Optical Imaging, Photodynamic Therapy, and Photothermal Therapy
Porphyrins
List of Acronyms and Abbreviations
References
Chapter 15. Magnetic Resonance Imaging and Alternating Magnetic Fields
Introduction
Key Concepts
Magnetic Nanoparticles as Contrast Agents for MRI Application
Magnetic Nanoparticles for Therapeutic Applications
Prospects and Conclusion
References
Chapter 16. Ultrasound for Drug/Gene Delivery
Barriers to Drug and Gene Delivery to Tumors
Biophysics of Therapeutic Ultrasound
Ultrasound-Facilitated Drug and Gene Delivery
Ultrasound-Responsive Nanoparticles as Drug and Gene Delivery Carriers
Therapeutic Applications of Drug and Gene Delivery
Potential Pitfalls in Ultrasound-Mediated Delivery into Tumor Tissue
Conclusions
Acknowledgments
References
Chapter 17. Radionuclides for Imaging and Therapy in Oncology
Introduction
Imaging Techniques and Radionuclides
Radiotherapy
Selection of Radionuclides
Theranostics: Dual/Pair Radionuclides
Biomarkers and Radiopharmaceutical Development
Radiopharmaceuticals in Oncology
Conclusion
References
Chapter 18. Noble Metal Nanoparticle Platform
Introduction
Physical, Chemical, and Biological Properties
Case Studies
Opportunities and Challenges
Acknowledgments
References
Chapter 19. Cancer Theranostics with Carbon-Based Nanoplatforms
Introduction
Fullerenes
Carbon Nanotubes
Graphene
C-Dots
Toxicity of Carbon Nanomaterials
Conclusion
Abbreviations
References
Chapter 20. Silica Nanoparticle Platform
Introduction
Biocompatibility
Nanoplatform Properties and their Role in Biocompatibility
Silica Toxicity
Synthesis and Surface Modification of Silica Nanoparticles
Silica Nanoparticle Nanotheranostics
Conclusions
References
Chapter 21. Quantum Dots for Traceable Therapeutic Delivery
Introduction
Design and Synthesis of Theranostic Quantum Dots
Applications of Theranostic Quantum Dots
Barriers to the Clinical Translation of Theranostic Quantum Dots
Perspectives and Conclusions
References
Chapter 22. Polymer- and Protein-Based Nanotechnologies for Cancer Theranostics
Introduction
Polymer-Based Theranostic Platform
Protein-Based Theranostic Platforms
Opportunities and Challenges
Acknowledgments
References
Part V: Other
Chapter 23. Clinical Translation and Regulations of Theranostics
Introduction
Nanomedicine: The Vehicle
Molecular Imaging Probes: Linkage and Diagnostic
Biomarkers: The Target
Anticancer: Therapy
Determining Regulatory Requirements
Early Phase Trials
Investigational Drug Application
Combination Products
Companion Products
Alternate Paths to Regulatory Approval
Institutional Review Board
Reducing Bias
Conclusion
Glossary
Clinical Trial Phases Devices
Clinical Trial Phases (Drugs)
References
Chapter 24. Scale-Up Production of Theranostic Nanoparticles
Introduction
Current Preparation Methods of Theranostic Nanoparticles
Current Scale-Up Processes
Pilot Plant Design for Theranostic Nanoparticles
Sterilization
Summary and Future Perspectives
Acknowledgment
References
Chapter 25. Market Considerations for Nanomedicines and Theranostic Nanomedicines
Key Concepts
Introduction
Nanotechnologies Enabling Technologies
Nanotechnology Applications in Medicine and Business Model Selection
Nanotechnology and Nanomedicine Patenting Systems
Nanotechnology and Nanomedicine Regulatory, Legal, Ethical, and Policy Issues
Conclusion
References
Chapter 26. Application of Theranostics to Measure and Treat Cell Heterogeneity in Cancer
Key Concepts
Introduction
Different Facets of Cellular Heterogeneity in Cancer
Tools to Detect and Measure Cell Heterogeneity
New Directions for the Management of Cell Heterogeneity in Cancer Via the Development of Theranostics
Conclusion
Acknowledgments
Glossary
Acronyms and Abbreviations
References
Index
No. of pages: 544
Language: English
Edition: 1
Published: March 20, 2014
Imprint: Academic Press
Hardback ISBN: 9780124077225
eBook ISBN: 9780124078840
XC
Xiaoyuan Chen
Xiaoyuan (Shawn) Chen, PhD, is a Senior Investigator and Chief of the Laboratory of Molecular Imaging and Nanomedicine (LOMIN) at the National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH). He is also founding editor of journal Theranostics. He holds a PhD in Chemistry from the University of Idaho.
Affiliations and expertise
Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health
SW
Stephen Wong
Stephen T.C. Wong, PhD (Computer Science), PE (Electrical Engineering), is John S. Dunn Distinguished Endowed Chair of Biomedical Engineering at Houston Methodist Hospital, the Founding Chair of Department of Systems Medicine and Bioengineering at Houston Methodist Research Institute, and a Professor of Radiology, Neurosciences, Pathology, and Laboratory Medicine at Weill Cornell Medical College.