Advances in Immunology

Advances in Immunology, 1st Edition

Advances in Immunology, 1st Edition,Frederick Alt,ISBN9780124077089

Advances in Immunology

F Alt   

Academic Press




229 X 152

This series continually publishes cutting-edge reviews in the field of immunology

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Key Features

  • Contributions from leading authorities
  • Informs and updates on all the latest developments in the field


Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.


Immunologists and infectious disease specialists, cell biologists and hematologists

Frederick Alt

Affiliations and Expertise

Howard Hughes Medical Institute Research Laboratories, The Children's Hospital, Boston, MA, USA

View additional works by Frederick W. Alt

Advances in Immunology, 1st Edition

Series Page


Chapter One. Fate Determination of Mature Autoreactive B Cells

1 Introduction

2 Formation of the Naive B Cell Repertoire

3 B Cell Activation

4 The Cellular Composition of GC

5 The GC Response

6 Regulating Autoreactivity Within the GC

7 Cellular Mediators of GC Selection

8 Regulation of Plasma Cells

9 Conclusion


Chapter Two. Epigenetic Control of Cytokine Gene Expression: Regulation of the TNF/LT Locus and T Helper Cell Differentiation

1 The Components of Epigenetic Transcriptional Regulation

2 Cytokine Gene Regulation

3 Perspectives and Future Directions


Chapter Three. Autoimmunity in Rheumatoid Arthritis: Citrulline Immunity and Beyond

1 Introduction

2 Present State of the Art Concerning Genes, Environment, and Anticitrulline Immunity in RA

3 Unresolved Issues Concerning the Specificity and Genetic Basis of Autoimmune Reactions in RA: Focus on the Heterogeneity of the RA Syndrome

4 Unresolved Issues Concerning the Triggering of Various Autoimmune Reactions in RA: Focus on Events Outside the Joints

5 Unresolved Issues Concerning the Contributions of Various Autoimmune Reactions to Symptoms of RA: Focus on Events in Joints and in Sites of Extra-Articular Manifestations of RA

6 Conclusions Concerning Research Strategies and Efforts to Turn the Emerging Insights of Adaptive Immunity in RA into Personalized Prevention and Therapy



Contents of Recent Volumes

Quotes and reviews

"The series which all immunologists need." --The Pharmaceutical Journal

"Advances in Immunology must find itself among the most active volumes in the libraries of our universities and institutions." --Science

"Deserves a permanent place in biomedical libraries as an aid in research and in teaching." --Journal of Immunological Methods

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