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Advances in Cancer Research
 
 

Advances in Cancer Research, 1st Edition

 
Advances in Cancer Research, 1st Edition,Kenneth Tew,Paul Fisher,ISBN9780124071902
 
 
 

Advances in Cancer Research

Tew   &   Fisher   

Academic Press

9780124071902

9780124072114

504

229 X 152

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research.

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Description

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics.

Readership

Researchers and students in the basic and clinical sciences of cancer biology and oncology, plus related areas in genetics, immunology, pharmacology, cell biology, and molecular biology.

Kenneth Tew

Professor & Chairman, Dept of Cell & Molecular Pharmacology John C. West Chair of Cancer Research, Medical University of South Carolina, USA The Tew laboratory maintains an interest in using redox pathways as a platform to develop therapeutic strategies through drug discovery/development and biomarker identification. We interrogate how reactive oxygen and nitrogen species (ROS/RNS) impact cancer cells and develop novel drugs that impact on glutathione based pathways. Our research efforts have been integral to studies that have identified glutathione S-transferases (GST) as important in drug resistance, catalytic detoxification and as arbiters of kinase-mediated cell signaling events. In addition, we have been instrumental in defining how GSTP contributes to the process by which cells respond to ROS by selective addition of glutathione to specific protein clusters, so called S-glutathionylation. Each of these research areas has had broad impact on a number of cancer disciplines. Moreover, we have also been seminally involved in the Phase I to III clinical testing of three oncology drugs, Telcyta, Telintra and NOV-002. Other ongoing translational efforts have produced two ongoing clinical trials to measure the effectiveness of serum S-glutathionylated serine proteinase inhibitors as possible biomarkers for exposure to hydrogen peroxide mouthwashes and radiation.

Affiliations and Expertise

Deptartment of Cell & Molecular Pharmacology, Medical University of South Carolina, USA

Advances in Cancer Research, 1st Edition

  1. Vaccines for Cancer: Past, Present and Future
    Xiang-Yang Wang
  2. Understanding the role of Ets-mediated gene regulation in complex biological processes
    Dennis K. Watson
  3. Non-Small Cell Lung Cancer
    Srikumar P. Chellappan
  4. Mitochondrial Alterations During Carinogenesis
    Carlos Moraes
  5. Human polynucleotide phosphorylase (hPNPaseold-35): should I eat you or not- that is the question?
    Paul B. Fisher

Quotes and reviews

Praise for the Serial:
"This classic and essential series presents critical overviews on select aspects of both cancer research and the basic underlying sciences."--AMERICAN SCIENTIST
"Excellent, highly informative, in-depth reviews...expertly written, up-to-date, and well-referenced."--JOURNAL OF MEDICINAL CHEMISTRY
"This is a series that has a long tradition of excellence in the field of cancer biology."--DOODY'S PUBLISHING REVIEWS
 
 

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