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Chronic Pain and Brain Abnormalities
1st Edition - June 28, 2013
Author: Carl Y. Saab
Language: English
Hardback ISBN:9780123983893
9 7 8 - 0 - 1 2 - 3 9 8 3 8 9 - 3
eBook ISBN:9780124058965
9 7 8 - 0 - 1 2 - 4 0 5 8 9 6 - 5
It is only natural for someone in pain to attend to the body part that hurts. Yet this book tells the story of persistent pain having negative effects on brain function. The co…Read more
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It is only natural for someone in pain to attend to the body part that hurts. Yet this book tells the story of persistent pain having negative effects on brain function. The contributors, all leading experts in their respective fields of pain electrophysiology, brain imaging, and animal models of pain, strive to synthesize compelling and, in some ways, connected hypotheses with regard to pain-related changes in the brain. Together, they contribute their clinical, academic, and theoretical expertise in a comprehensive overview that attempts to define the broader philosophical context of pain (disentangling sensical from nonsensical claims),list the changes known to take place in the brains of individuals with chronic pain and animal models of pain, address the possible causes and mechanisms underlying these changes, and detail the techniques and analytical methods at our disposal to "visualize" and study these changes.
Philosophical and social concepts of pain; testimonials of chronic-pain patients
Clinical data from pain patients’ brains
Advances in noninvasive brain imaging for pain patients
Combining theoretical and empirical approaches to the analysis of pain-related brain function
Manipulation of brain function in animal models
Emerging neurotechnology principles for pain diagnostics and therapeutics
Researchers and graduate students in pain neuroscience, neurology, neurosurgery, pain management and anesthesiology
Dedication
Preface
Reference
List of Contributors
List of Figures
Chapter 1. Introduction
Rationale and Scope of this Book
What is Pain?
Pain in Animals
Pain We Need
Pain We Don’t Need
Real Faces of Pain: Case Illustrations
Pain; more than a Numbers Game
Why Focus on the Brain? A Philosophical Perspective
References
Chapter 2. Morphological Brain Changes in Chronic Pain: Mystery and Meaning
Introduction
Methodological Approaches to Measures of Morphometric Changes in the CNS
The Brain and Plasticity
Alterations in Gray and White Matter—Pathophysiological Processes
Brain Changes and Chronic Pain
Brain Targets for Treatment
Biomarker in Chronic Pain: Structural-Functional Relationships
Conclusions
References
Chapter 3. Thalamic Burst Firing in Response to Experimental Pain Stimuli and in Patients with Chronic Neuropathic Pain may be a Carrier for Pain-Related Signals
Introduction
Pain-Related Activity in SI Cortex
Cortical Pain Network
Pain Processing in the Region of Vc
Thalamic Burst Firing Patterns
Thalamic Firing Patterns in Relation-Directed Attention and Distraction
Thalamic Firing Patterns in Relation to Painful Stimuli
Thalamic Firing Patterns in Chronic Pain
Acknowledgements
References
Chapter 4. Central Pain: A Thalamic Deafferentation Generating Thalamocortical Dysrhythmia
Introduction
Deafferentation Pain Syndromes
Peripheral Pain Syndromes
Complex Regional Pain Syndrome
Intraoperative Recordings and Thalamic Lesions
High Frequency Firing and the Edge Effect
Discussion
References
Chapter 5. Surgical Interventions for Pain
Neurosurgical Procedures
Neuromodulation- Relieving Pain by Modulating Pain Pathways
Neuroablation- Relieving Pain by Interrupting Pain Pathways
Further Reading
Chapter 6. Thalamocortical Abnormalities in Spinal Cord Injury Pain
SCI-Pain
Animal Models of SCI-Pain
Pathophysiology of SCI-Pain
Spinal Abnormalities
Thalamic Abnormalities
Abnormalities in Inhibitory Inputs to Thalamic Nuclei
Cortical Abnormalities
Thalamocortical Abnormalities
Therapies to Restore Inhibition to Thalamic Nuclei
Acknowledgments
References
Chapter 7. Discussion
So What’s Novel about this Book?
In Defense of Studying the Brain
To Image a Whole Brain, not Just its Parts
Self-Critique of a Pain Neuroscientist
References
Index
No. of pages: 176
Language: English
Edition: 1
Published: June 28, 2013
Imprint: Academic Press
Hardback ISBN: 9780123983893
eBook ISBN: 9780124058965
CS
Carl Y. Saab
Affiliations and expertise
Department of Neuroscience and Department of Neurosurgery, Brown University, Providence, Rhode Island, USA
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