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Immunopharmacology
 
 

Immunopharmacology, 1st Edition

 
Immunopharmacology, 1st Edition,David Webb,ISBN9780124047174
 
 
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Advances in Pharmacology

D Webb   

Academic Press

9780124047174

9780124051843

352

229 X 152

This new volume of Advances in Pharmacology explores immunopharmacology. With a variety of chapters and the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike.

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Key Features

  • Explores the current state of Alzheimer's disease research and therapeutics
  • Chapters cover a variety of topics such as the B cell targeted therapies, lymphotoxin family receptors in inflammation, and allergic inflammation and thymic stromal lymphopoietin
  • With the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike

Description

This new volume of Advances in Pharmacology explores the current state of Alzheimer's disease research and therapeutics. Chapters cover such topics as the B cell targeted therapies, Lymphotoxin family receptors in inflammation, and allergic inflammation and thymic stromal lymphopoietin. With a variety of chapters and the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike.

Readership

Pharmacologists, immunologists, and biochemists

Information about this author is currently not available.

Immunopharmacology, 1st Edition

Preface

Contributors

Chapter One. Redefining Approaches to Asthma: Developing Targeted Biologic Therapies

Abstract

1. Introduction

2. Human Asthma Biology

3. Pharmacokinetics and Pharmacodynamics of Asthma Biologics

4. Clinical Study Design for Asthma Biologics

5. Conclusion

Acknowledgments

References

Chapter Two. Protein Therapeutics Targeted at the TNF Superfamily

Abstract

1. Introduction

2. The TNF and TNF Receptor Superfamilies

3. Antibody and Receptor-Based Drugs

4. Clinical Responses to TNF Inhibitors

5. Targeting Other TNFSF Pathways

6. Conclusion

Acknowledgments

References

Chapter Three. Immunopharmacology of Lipid A Mimetics

Abstract

1. Introduction

2. LPS Receptor Complex

3. TLR4 Signaling

4. Endotoxin

5. Structure of LPS

6. Lipid A: The “Endotoxic Principle”

7. Diversity of Lipid A in Nature

8. Synthetic Lipid A

9. TRIF-Selective Signaling

10. Conclusion

References

Chapter Four. The Biology of Thymic Stromal Lymphopoietin (TSLP)

Abstract

1. Introduction

2. TSLP Signaling

3. TSLP-Responsive Cells

4. TSLP-Associated Diseases

5. Conclusion

Acknowledgments

References

Chapter Five. Eicosanoids in Metabolic Syndrome

Abstract

1. Introduction

2. Lipid Metabolism in Control of Eicosanoid Synthesis

3. Metabolism of Eicosanoids in MetS

4. Eicosanoids in Sepsis and Drug Metabolism

5. Eicosanoids and MetS Diseases

6. Therapies in the Treatment of NAFLD

7. Conclusion

Acknowledgments

References

Chapter Six. The Yin and Yang of Protein Kinase C-theta (PKCθ): A Novel Drug Target for Selective Immunosuppression

Abstract

1. Introduction

2. History, Structure and Expression of PKCθ

3. Specialized Functions of PKCθ in Conventional T Cells: The Yin

4. The Differential Role of PKCθ in Immune Responses

5. PKCθ and the Immunological Synapse

6. PKCθ, CD28 Costimulation, and T Cell Anergy

7. Unique Function of PKCθ in Regulatory T Cell Development and Function: The Yang

8. PKCθ in Human Disease

9. Is PKCθ a Promising Drug Target?

10. Conclusion and Future Perspectives

Acknowledgments

References

Index

 
 
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