Neural Crest Cells

Neural Crest Cells, 1st Edition

Evolution, Development and Disease

Neural Crest Cells, 1st Edition,Paul Trainor,ISBN9780124017306

P Trainor   

Academic Press




235 X 191

A publication providing a deeper understanding of how neural crest cells decide where to go and what to become based on temporal and spatial gradients

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Key Features

  • BMA Medical Book Awards 2014 - Highly Commended,Basic and Clinical Sciences,2014, British Medical Association
  • Provides timely, comprehensive synthesis of the current knowledge of neural crest cells
  • Covers the evolution and development of neural crest cells
  • Includes content on applications for tissue engineering, repair and regeneration


Neural Crest Cells: Evolution, Development and Disease summarizes discoveries of historical significance and provides in-depth, current analyses of the evolution of neural crest cells, their contribution to embryo development, and their roles in disease. In addition, prospects for tissue engineering, repair and regeneration are covered, offering a timely synthesis of the current knowledge in neural crest cell research. A comprehensive resource on neural crest cells for researchers studying cell biology, developmental biology, stem cells and neurobiology, Neural Crest Cells: Evolution, Development and Disease provides foundational information needed for students , practicing physicians and dentists treating patients with craniofacial defects.


Researchers across cell biology, developmental biology, stem cells; Medical and Dental students and teaching faculty

Information about this author is currently not available.

Neural Crest Cells, 1st Edition




Part I: Neural Crest Cell Evolution and Development

Chapter 1. The Neural Crest, a Fourth Germ Layer of the Vertebrate Embryo: Significance in Chordate Evolution

General Characteristics of the Neural Crest

Transition from Invertebrates Chordates to Vertebrates

The Molecular Control of EMT Studied in NCC Development

Role of the NC in the Development of the Vertebrate Head

The Evolutionary Origin of the Vertebrate Nervous System

The Genetic Identity of Vertebrate Secondary Brain Organizers as Landmarks for CNS Evolution in Deuterostomes

Are Precursors of the NC Present in non-vertebrate Chordates?

The Multiple Roles of the NC in the Construction of the Vertebrate Head and Brain

Hox Gene Expression in the Cephalic NC

Malformations of the Brain Induced by FSNC Removal

Effect of Forced Expression of Hox Genes in the FSNC on Face and Brain Development

Role of the Cephalic NC in the Regulation of Fgf8 Production by the ANR and Isthmus

The Evolution of Skeletal Structures in the Vertebrate Phylum

Conclusions and Perspectives



Chapter 2. Induction and Specification of Neural Crest Cells: Extracellular Signals and Transcriptional Switches


NC Induction at the NPB

Gene Regulatory Network Involved in NC Specification

Conclusions and Perspectives



Chapter 3. The Cell Biology of Neural Crest Cell Delamination and EMT


Loss of Intercellular Adhesion

Acquisition of Migratory Capacity

Appropriate Substrate for Migration

Conclusions and Perspectives


Chapter 4. Neural Crest Cell Migration: Guidance, Pathways, and Cell–Cell Interactions

Pathways of Neural Crest Cell Migration: An Overview

Cephalic Neural Crest Cell Migration

Trunk Neural Crest Cell Migration

Cell–Cell Interactions During Neural Crest Cell Migration

Conclusion and Perspectives



Chapter 5. Epigenetic Regulation of Neural Crest Cells


Histone Modifications

Chromatin Modifiers

DNA Methylation

Conclusions and Perspectives



Chapter 6. Neural Crest-Mediated Tissue Interactions During Craniofacial Development: The Origins of Species-Specific Pattern


Origins of Species-Specific Pattern

Conclusions and Perspectives


Part II: Neural Crest Cell Differentiation and Disease

Chapter 7. Neural Crest Cells in Craniofacial Skeletal Development


Skeletogenic NC Specification and Anterior–Posterior Patterning

Patterning Within Craniofacial Skeletal Primordia

Environmental Factors in Craniofacial Development

Cranial NC Development and Evolution

Conclusions and Perspectives


Chapter 8. Neural Crest Cell and Placode Interactions in Cranial PNS Development

The Cranial Peripheral Nervous System

Ectodermal Placodes


Evolutionary Significance

Conclusions and Perspectives



Chapter 9. Neural Crest Cells in Ear Development

The Ear

Timing and Position of Otic NCC Emigration

NCC Derivatives in the Inner Ear

NCC in Middle Ear and Outer Ear Development

Neurocristopathies of the Middle and Outer Ear

Genetic Regulation of NCC Middle and Outer Ear Development

NCC and Evolution of the Ear

Concluding Remarks


Chapter 10. Neural Crest Cells in Ocular Development


Neural Crest and Early Eye Development

Signaling Between NCC and the Optic Cup

Signaling Between NCC and the Lens

Signaling Between NCC and Ectoderm

Other Contribution of NCC to Ocular Tissues

Indirect Neural Crest Contribution to the Eye via Trigeminal and Ciliary Nerves

Neural Crest Related Ocular Defects

Conclusions and Perspectives


Chapter 11. The Cardiac Neural Crest and Their Role in Development and Disease


NCC Specification

Migration and Morphogenesis of the cNCC

Invasion of the cNCC into the Pharyngeal Arches and OFT Cushions

Remodeling of the Pharyngeal Arch Arteries

Septation of the OFT

Valvulogenesis in the OFT

NCC Differentiation

Evolution of Neural Crest Cell Contribution to the Heart

Molecular Regulators of cNCC Development and Links to Congenital Heart Disease

Dietary Factors Influencing Cardiac Neural Crest Cell Development

Conclusions and Perspectives



Chapter 12. Neural Crest Cells in Enteric Nervous System Development and Disease


GDNF, GFRα1, and RET Signaling

Neuturin, GFRα2, and RET Signaling

Endothelin 3 (EDN3)/Endothelin Receptor B (EDNRB) Signaling

Signaling Pathway Interactions in ENS Development and HSCR

Genes Involved in ENS Development, not Currently Associated With Human Disease

Regulation of the NCC Population That Migrates Toward and Then into the Foregut

Regulation of ENCC Survival, Migration, Proliferation, and Differentiation Within the Gut Wall

Conclusions and Perspectives



Chapter 13. Neural Crest Cells and Peripheral Nervous System Development


Definition of Trunk Neural Crest

Divergent Neural Crest Migratory Pathways Reflect Fate Restriction of the Trunk Neural Crest

Neural Crest Fate Restriction begins Long Before the Observation of Overt Differentiation Markers

Factors that Specify the Neural Crest Continue to Modify Neural Crest Fate Proliferation, Survival, and Fate Choice

The Survival and Multipotency of Trunk Neural Crest Is Maintained by Several Transcription Factors Expressed During Migration

ErbB/Neuregulin Signaling Supports Neural Crest Migration and Glial Development

Neural Crest Are Instructed to Develop as Autonomic Neurons by BMP Signals Emanating from the Dorsal Aorta

The Transcriptional Cascade Leading to Autonomic Nervous System Differentiation Is Extensively Cross-Regulatory

DRG Formation Occurs in Overlapping Waves of Neurogenesis That Can Be Followed Using the Trk Receptor Family as Markers of Cell Fate

The DRG Transcriptional Cascade Is Hierarchical and Sorts Cells into Subtypes

The Subsequent Expression of Other Transcription Factors Is Essential to DRG Development and Maintenance

Conclusions and Perspectives: Common Features in Autonomic and Sensory Neuronal Development


Chapter 14. Neural Crest Cells and Pigmentation


Timing of Pigment Cell Development

Fate Choice/Specification


Migration and Patterning

Proliferation and Survival


Conclusions and Perspectives


Chapter 15. Neural Crest Cells in Vascular Development


Blood Vessel Development and Structure

Neural Crest Contribution to Blood Vessels

Innervation of the Vasculature by the ANS

Neural Crest Involvement in Neurovascular Patterning

Conclusions and Perspectives


Chapter 16. Neural Crest Cells and Cancer: Insights into Tumor Progression


Similarities Between Neural Crest Delamination/Migration and Tumor Progression

Neural Crest-Derived Cancers

Conclusions and Perspectives


Part III: Tissue Engineering and Repair

Chapter 17. Neurocristopathies: The Etiology and Pathogenesis of Disorders Arising from Defects in Neural Crest Cell Development


Conclusions and Perspectives



Chapter 18. Human Neural Crest Cells and Stem Cell-Based Models


Surrogate Models of Human Neural Crest Development

Conclusions and Perspectives


Chapter 19. Neural Crest Stem Cell: Tissue Regeneration and Repair


Gingival MSC

Dental MSC


TMJ Stem Cells

Bone Marrow Mesenchymal Stem Cells (BMMSCs)

Adipose MSC

Conclusions and Perspectives


Chapter 20. Functional Significance of Cranial Neural Crest Cells During Tooth Development and Regeneration


Tooth Development

CNCC and Dental Stem Cells

Conclusions and Perspectives



Chapter 21. Using Induced Pluripotent Stem Cells as a Tool to Understand Neurocristopathies


Neural Crest Cells and Neurocristopathies

Methods for NCC Differentiation from Pluripotent Stem Cells


Conclusions and Perspectives



Quotes and reviews

"This text is a tour de force in its field and is of significance to embryologists, craniofacial biologists, geneticists, syndromologists and oral and maxillofacial surgeons for its concepts and innovations in this rapidly expanding field. The quality of production from Academic Press is superb, providing a landmark reference work for those in the forefront of craniofacial research and regenerative surgical therapy."--British Dental Journal, May 23, 2014

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