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Current Concepts in Drug Metabolism and Toxicology
 
 

Current Concepts in Drug Metabolism and Toxicology, 1st Edition

 
Current Concepts in Drug Metabolism and Toxicology, 1st Edition,Gabrielle M. Hawksworth,ISBN9780123983398
 
 
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Advances in Pharmacology

G Hawksworth   

Academic Press

9780123983398

9780123983596

304

229 X 152

This new volume of Advances in Pharmacology explores the current concepts in drug metabolism and toxicology and is an essential resource for pharmacologists, immunologists and biochemists alike

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Key Features

  • Explores the current concepts in drug metabolism and toxicology
  • Chapters cover such areas as the Keap1-Nrf2 cell defense pathway, animal models of drug-induced idiosyncratic toxicity and the use of human embryonic and induced pluripotent stem cells for modeling metabolism and toxicity
  • An essential resource for pharmacologists, immunologists and biochemists alike

Description

This new volume of Advances in Pharmacology explores the current concepts in drug metabolism and toxicology. Chapters cover the Keap1-Nrf2 cell defense pathway, animal models of drug-induced idiosyncratic toxicity and the use of human embryonic and induced pluripotent stem cells for modeling metabolism and toxicity. With a variety of chapters and the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike.

Readership

Pharmacologists, immunologists, and biochemists

Information about this author is currently not available.

Current Concepts in Drug Metabolism and Toxicology, 1st Edition

Contributors

Membrane Transporters in Drug Development

I Introduction

II Key Features of Transporters

III Transporters and the Pharmaceutical Industry

IV Studying and Contextualizing Transporter Interactions: Application and Interpretation of Data

V The Transporter Toolkit, its Opportunities and Challenges

VI Conclusion

Acknowledgments

Abbreviations

The Keap1–Nrf2 Cell Defense Pathway – A Promising Therapeutic Target?

I Introduction

II The Keap1–Nrf2 Cell Defense Pathway

III Activation of Nrf2 as a Potential Therapeutic Strategy

IV Inhibition of Nrf2 as a Potential Therapeutic Strategy

V Conclusion

Abbreviations

Animal Models of Idiosyncratic Drug Reactions

I Introduction

II Animal Models of Skin Rash

III Animal Models of Liver Toxicity

IV Animal Models of Hematological Toxicity

V Animal Models of Generalized Hypersensitivity Reactions

VI Animal Models of Generalized Autoimmunity

VII Conclusion

Abbreviations

Genetic Polymorphisms Affecting Drug Metabolism

I Introduction

II Recent Advances in the Pharmacogenetics of Cytochromes P450

III Recent Advances in the Pharmacogenetics of Non-P450 Metabolism

IV Clinical Relevance of Polymorphic Metabolism – Some Contemporary Examples

V Conclusion

Abbreviations

Arylamine N-Acetyltransferases – from Drug Metabolism and Pharmacogenetics to Identification of Novel Targets for Pharmacological Intervention

I Introduction

II NAT Enzyme Mechanism

III NAT Genes and Pharmacogenetics

IV The Genomic Distribution and Function of NATs

V NAT Gene Expression and Regulation

VI Development of NAT Inhibitors

VII Conclusion

Abbreviations

Human Pluripotent Stem Cells for Modeling Toxicity

I Introduction

II The Use of Human Stem Cells in Developmental Toxicity

III The Use of Human Stem Cells in Cardiotoxicity

IV The Use of Human Stem Cells in Hepatotoxicity

V The Use of Human Stem Cells in Neurotoxicity

VI Conclusion

Abbreviations

Disposition of Biologics

I Introduction

II Routes of Administration

III Mechanisms of Biologics Distribution and Clearance, The Importance of Active Processes

IV Distribution Studies with Biologics and Relevance to Toxicology Studies

V Metabolism of Biologics

VI Consideration of Immunogenicity – Changes in Disposition and Impact on Toxicology

VII Conclusion

Abbreviations

Index

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