»
Current Concepts in Drug Metabolism and Toxicology
 
 

Current Concepts in Drug Metabolism and Toxicology, 1st Edition

 
Current Concepts in Drug Metabolism and Toxicology, 1st Edition,Gabrielle M. Hawksworth,ISBN9780123983398
 
 
 

Advances in Pharmacology

G Hawksworth   

Academic Press

9780123983398

9780123983596

304

229 X 152

This new volume of Advances in Pharmacology explores the current concepts in drug metabolism and toxicology and is an essential resource for pharmacologists, immunologists and biochemists alike.

Print Book + eBook

USD 303.00
USD 505.00

Buy both together and save 40%

Print Book

Hardcover

In Stock

Estimated Delivery Time
USD 256.00

eBook
eBook Overview

VST (VitalSource Bookshelf) format

DRM-free included formats : EPUB, Mobi (for Kindle), PDF

USD 249.00
Add to Cart
 
 

Key Features

  • Explores the current concepts in drug metabolism and toxicology
  • Chapters cover such areas as the Keap1-Nrf2 cell defense pathway, animal models of drug-induced idiosyncratic toxicity and the use of human embryonic and induced pluripotent stem cells for modeling metabolism and toxicity
  • An essential resource for pharmacologists, immunologists and biochemists alike
  • Description

    This new volume of Advances in Pharmacology explores the current concepts in drug metabolism and toxicology. Chapters cover the Keap1-Nrf2 cell defense pathway, animal models of drug-induced idiosyncratic toxicity and the use of human embryonic and induced pluripotent stem cells for modeling metabolism and toxicity. With a variety of chapters and the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike.

    Readership

    Pharmacologists, immunologists, and biochemists

    Information about this author is currently not available.

    Current Concepts in Drug Metabolism and Toxicology, 1st Edition

    Contributors

    Membrane Transporters in Drug Development

    I Introduction

    II Key Features of Transporters

    III Transporters and the Pharmaceutical Industry

    IV Studying and Contextualizing Transporter Interactions: Application and Interpretation of Data

    V The Transporter Toolkit, its Opportunities and Challenges

    VI Conclusion

    Acknowledgments

    Abbreviations

    The Keap1–Nrf2 Cell Defense Pathway – A Promising Therapeutic Target?

    I Introduction

    II The Keap1–Nrf2 Cell Defense Pathway

    III Activation of Nrf2 as a Potential Therapeutic Strategy

    IV Inhibition of Nrf2 as a Potential Therapeutic Strategy

    V Conclusion

    Abbreviations

    Animal Models of Idiosyncratic Drug Reactions

    I Introduction

    II Animal Models of Skin Rash

    III Animal Models of Liver Toxicity

    IV Animal Models of Hematological Toxicity

    V Animal Models of Generalized Hypersensitivity Reactions

    VI Animal Models of Generalized Autoimmunity

    VII Conclusion

    Abbreviations

    Genetic Polymorphisms Affecting Drug Metabolism

    I Introduction

    II Recent Advances in the Pharmacogenetics of Cytochromes P450

    III Recent Advances in the Pharmacogenetics of Non-P450 Metabolism

    IV Clinical Relevance of Polymorphic Metabolism – Some Contemporary Examples

    V Conclusion

    Abbreviations

    Arylamine N-Acetyltransferases – from Drug Metabolism and Pharmacogenetics to Identification of Novel Targets for Pharmacological Intervention

    I Introduction

    II NAT Enzyme Mechanism

    III NAT Genes and Pharmacogenetics

    IV The Genomic Distribution and Function of NATs

    V NAT Gene Expression and Regulation

    VI Development of NAT Inhibitors

    VII Conclusion

    Abbreviations

    Human Pluripotent Stem Cells for Modeling Toxicity

    I Introduction

    II The Use of Human Stem Cells in Developmental Toxicity

    III The Use of Human Stem Cells in Cardiotoxicity

    IV The Use of Human Stem Cells in Hepatotoxicity

    V The Use of Human Stem Cells in Neurotoxicity

    VI Conclusion

    Abbreviations

    Disposition of Biologics

    I Introduction

    II Routes of Administration

    III Mechanisms of Biologics Distribution and Clearance, The Importance of Active Processes

    IV Distribution Studies with Biologics and Relevance to Toxicology Studies

    V Metabolism of Biologics

    VI Consideration of Immunogenicity – Changes in Disposition and Impact on Toxicology

    VII Conclusion

    Abbreviations

    Index

    Recent Volumes in the Serial

     
     
    Free Shipping
    Shop with Confidence

    Free Shipping around the world
    ▪ Broad range of products
    ▪ 30 days return policy
    FAQ

    Contact Us