Adiponectin, 1st Edition

Adiponectin, 1st Edition,Gerald Litwack,ISBN9780123983138

Vitamins and Hormones

G Litwack   

Academic Press




229 X 152

Cutting-edge review concerning the molecular and cellular biology of vitamins and hormones

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Key Features

  • Contributions from leading authorities
  • Informs and updates on all the latest developments in the field


First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press.

Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.


Researchers, faculty, and graduate students interested in cutting-edge review concerning the molecular and cellular biology of vitamins, hormones, and related factors and co-factors. Libraries and laboratories at institutes with strong programs in cell biology, biochemistry, molecular biology, gene regulation, hormone control, and signal transduction are likely to be interested

Gerald Litwack

Following a liberal arts education with a major in chemistry and biology at Hobart College, Gerald (Gerry) Litwack earned M.S. and PhD degrees in biochemistry from the University of Wisconsin, Madison where he served as a Lecturer in Enzymology before starting a postdoctoral fellowship from the National Foundation for Infantile Paralysis at the Biochemical Institute of the Sorbonne in Paris. His first academic position was assistant professor of biochemistry at Rutgers University where he started his work on hormone action for six years. During this period, he did a sabbatical at the University of California, Berkeley, where he concentrated on rapid enzyme kinetics. In 1960 he accepted an offer of an associate professorship at the University of Pennsylvania Graduate School of Medicine. In 1964, he was invited to be full professor of biochemistry at The Fels Institute for Cancer Research and Molecular Biology at Temple Medical School, simultaneously with a Career Development Award from the NIH, where he later was named Deputy Director of the Institute and the Laura H. Carnell Professor in biochemistry. Subsequently, he was given the Faculty Research Award. He co-discovered ligandin, later found to be in the family of glutathione S-transferases, enzymes that protect the body from carcinogens. In 1991, he moved to the Jefferson Medical College at Thomas Jefferson University as Professor of Biochemistry, Chair of the Department of Pharmacology and Deputy Director of the Kimmel Cancer Research Institute. Later, he became chair of the combined Department of Biochemistry and Molecular Pharmacology and concurrently held the position of Vice Dean for Research. In 2003, he moved to Los Angeles and from 2004-2006 was a Visiting Scholar at the University of California, Los Angeles, in the Department of Biological Chemistry of the Geffen School of Medicine and, in this period, wrote “Human Biochemistry and Disease” a volume of 1254 pages. In 2007, he moved to Scranton, Pennsylvania, as Founding Chair of Basic Sciences and Acting Associate Dean for Research to start a new medical school, The Commonwealth Medical College. Having completing his mission in 2010, he moved to The Institute for Regenerative Medicine, Texas A & M Health Science Center, as Professor of Biochemistry and Associate Director. Currently, he is retired and lives in North Hollywood, California, where he continues as an author and as Series Editor of Vitamins and Hormones. He is involved in writing another textbook and has written a first novel, “One-Eighty”.

Affiliations and Expertise

Toluca Lake, North Hollywood, California, USA

View additional works by Gerald Litwack

Adiponectin, 1st Edition

Former Editors



Chapter One Lifestyle Factors Increasing Adiponectin Synthesis and Secretion

1 Introduction

2 Lifestyle Factors That Increase Adiponectin Synthesis and Secretion

3 Mechanisms for Lifestyle-Mediated Effects on Adiponectin

4 Conclusions

Chapter Two Molecular Tools to Characterize Adiponectin Activity

1 Introduction

2 Analysis of the Cellular Biology

3 Protein Structures

4 Searching for New Interaction Partners

5 Signaling Cascades and Physiological Effect

6 Conclusion

Chapter Three Nutritional and Hormonal Modulation of Adiponectin and its Receptors adipoR1 and adipoR2

1 Introduction

2 Nutritional Regulation of Adiponectin and Adiponectin Receptors

3 Hormonal Regulation of Adiponectin and Adiponectin Receptors

4 Conclusion

Chapter Four Regulation and Function of Adiponectin Receptors in Skeletal Muscle

1 Introduction

2 Adiponectin and Adiponectin Receptors

3 Adiponectin Signaling and Function in Skeletal Muscle

4 Transcriptional Regulation of AdipoRs in Skeletal Muscle Under Different Physiological and Pathophysiological Conditions

5 Molecular Mechanisms Regulating Muscle AdipoRs Transcription

6 Posttranscriptional Regulation of AdipoRs in Skeletal Muscle

7 Concluding Remarks

Chapter Five Screening for Adiponectin Secretion Regulators

1 Introduction

2 PPAR?-Dependent Adiponectin Secretion Regulators

3 PPAR ?-Independent Adiponectin Secretion Regulators

4 Other Adiponectin Secretion Regulators

5 Conclusions

Chapter Six Adiponectin and PPAR?

1 PPAR? Activity Correlates with Adiponectin Hormone Levels

2 PPAR? Regulates Adiponectin Gene Transcription

3 PPAR? Regulates Adiponectin Hormone Secretion

4 PPAR? and Adiponectin Regulate Similar Physiological Pathways

5 Conclusion

Chapter Seven Glucocorticoid Effects on Adiponectin Expression

1 Introduction

2 Glucocorticoids and Their Effects on Gene Expression

3 Effects of GC and Adiponectin on Energy Metabolism

4 In Vitro and Animal Studies on the Effects of GC on Adiponectin Expression

5 Clinical Studies on the Effects of GC on Adiponectin Expression

6 Other Hormones, Factors, and Conditions That Regulate Adiponectin Expression and Their Relationship to GC

7 Potential Reasons for Contradictory Results on the Effects of GC on Adiponectin Expression and Methods That can be Useful in Gaining Better Insight About This Regulation

8 Conclusion

Chapter Eight Adiponectin and Reproduction

1 Introduction

2 Adiponectin and Adiponectin Signaling

3 Adiponectin: Main Functions in Human

4 Adiponectin and Steroidogenesis

5 Adiponectin and Placental Functions

6 Adiponectin and Pregnancy-Associated Pathologies

7 Conclusions and Perspectives

Chapter Nine Adiponectin and Its Receptors in Preimplantation Embryo Development

1 Introduction

2 Adiponectin and Fertility

3 Overview of Preimplantation Embryo Development

4 Expression of Adiponectin and Adiponectin Receptors in Oocytes and Preimplantation Embryos

5 Potential Roles of Adiponectin in Oocyte and Early Embryo Development

6 Conclusions

Chapter Ten Adiponectin and the Control of Female Reproductive Functions

1 Introduction

2 Adiponectin in Ovarian Functions

3 Adiponectin in Pregnancy

4 Adiponectin Action on the Central Nervous System and the Pituitary Gland

5 Conclusion

Chapter Eleven Adiponectin in the Heart and Vascular System

1 Introduction to Adiponectin

2 Adiponectin and CVD in Humans

3 Protective Effects of Adiponectin in the Cardiovascular System: Evidence from Rodent and In Vitro Studies

4 Conclusions/Future Questions

Chapter Twelve Adiponectin Interactions in Bone and Cartilage Biology and Disease

1 Introduction

2 Adipose, Bone, and Cartilage Relationships: Observations in Humans

3 Adiponectin, Bone, and Cartilage: Interactions in Humans

4 Adiponectin, Bone, and Cartilage: Experimental Observations

5 Conclusions

Chapter Thirteen Lipid-Lowering Drugs and Circulating Adiponectin

1 Introduction

2 Adiponectin

3 Statins

4 Fibrates

5 Niacin

6 Omega-3 Fatty Acids

7 Conclusions

Chapter Fourteen Adiponectin and Interleukin-6 in Inflammation-Associated Disease

1 Introduction

2 Biological Actions and Signaling Pathways Activated by Adiponectin

3 Interaction Between Adiponectin and IL-6 in Regulating Diabetic State

4 Interaction Between Adiponectin and IL-6 in Regulating Cardiovascular Disease

5 Interaction Between Adiponectin and IL-6 in Regulating Autoimmune Disease

6 Conclusion

Chapter Fifteen New Insights into Anticarcinogenic Properties of Adiponectin

1 Introduction

2 Adiponectinemia

3 Adiponectin and Breast Cancer Risk

4 Adiponectin as Therapeutic Target

5 Conclusion

Chapter Sixteen Adiponectin

1 Introduction

2 Structure of APN: Similarity to Surfactant Proteins

3 Expression and Regulation of APN in the Lung

4 COPD-Like Phenotype in APN-KO Mice

5 Mechanisms of COPD-Like Phenotype in APN-KO Mice

6 Therapeutic Potential of APN

7 Conclusion


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