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Structural and Mechanistic Enzymology:
 
 

Structural and Mechanistic Enzymology:, 1st Edition

Bringing Together Experiments and Computing

 
Structural and Mechanistic Enzymology:, 1st Edition,Christo Christov,Tatyana Karabencheva-Christova,ISBN9780123983121
 
 
 

Christov   &   Karabencheva-Christova   

Academic Press

9780123983121

9780123983183

472

229 X 152

Focuses on the recent success in structural and mechanistic enzymology.

Has its main emphasis on explaining the enzyme phenomena by using both the experimental and computational approaches.

Demonstrates how the application of a variety of experimental techniques and modeling methods helps further the understanding of enzyme dynamics, mechanism, inhibition, and drug design.

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Key Features

Focuses on the recent success in structural and mechanistic enzymology.

Has its main emphasis on explaining the enzyme phenomena by using both the experimental and computational approaches.

Demonstrates how the application of a variety of experimental techniques and modeling methods helps further the understanding of enzyme dynamics, mechanism, inhibition, and drug design.

    Description

    Both strategies for investigation (computational and experimental) in structural and mechanistic Enzymology have developed to some extent independently. However, over the last few years a trend has emerged for strengthening their integration. This combination not only brings together computations and experiments focused on the same enzymatic problems, but also provides complementary insights into the investigated properties and has a powerful synergy effect. This thematic volume of Advances in Protein Chemistry and Structural Biology focuses on the recent success in structural and mechanistic enzymology and has its main emphasis on explaining the enzyme phenomena by using both the experimental and computational approaches. The selected contributions demonstrate how the application of a variety of experimental techniques and modeling methods helps further the understanding of enzyme dynamics, mechanism, inhibition, and drug design.

    Readership

    Biochemists, biophysicists, cell biologists, protein chemists, structural geneticists, and structural biologists

    Christo Christov

    Affiliations and Expertise

    Northumbria University, UK

    View additional works by Christo Christov

    Tatyana Karabencheva-Christova

    Affiliations and Expertise

    Northumbria University, UK

    View additional works by Tatyana Karabencheva-Christova

    Structural and Mechanistic Enzymology:, 1st Edition

      1. Structural and Computational Enzymology: Bringing Experiments and Computations Together
      2. Tatyana Karabencheva and Christo Christov

      3. Structural and Functional Analysis of Proteins by High-Speed Atomic Force Microscopy
      4. Arivazhagan Rajendran, Masayuki Endo and Hiroshi Sugiyama

      5. Reaction Intermediates Discovered in Crystal Structures of Enzymes
      6. Irene T. Weber, Johnson Agniswamy, Guoxing Fu, Chen-Hsiang Shen and Robert W. Harrison

      7. Structural, Functional and Mutagenesis Studies of UDP-Glycosyltransferases
      8. Vatsala Malik and Gary W Black

      9. Vipoxin and its Components: Structure – Function Relationship
      10. S. D. Petrova, V. N. Atanasov and K. Balashev

      11. Experimental and Theoretical Studies of Enzyme-Catalyzed Hydrogen Transfer Reactions
      12. Zhen Wang, Daniel Roston and Amnon Kohen

      13. Protein Flexibility and Enzymatic Catalysis
      14. M. Kokkinidis, N. M. Glykos and V. E. Fadouloglou

      15. Molecular Modeling of Inhibitors of Human DNA Methyltransferase with a Crystal Structure: Discovery of a Novel DNMT1 Inhibitor
      16. Jakyung Yoo, Joo Hee Kim, Keith D. Robertson and José L. Medina-Franco

      17. In Silico Strategies Towards Enzyme Function and Dynamics
      18. Sílvia G. Estácio

      19. Dynamic Simulations as a Complement to Experimental Studies of Enzyme Mechanisms
      20. Andrew Christofferon, Lifeng Zhao and Qiang Pei

      21. The Increasing Role of QM/MM in Drug Discovery
      22. Alessio Lodola and Marco De Vivo

      23. Probing Allostery and Binding Cooperativity of the Catalytic Subunit of Protein Kinase A by NMR Spectroscopy and Molecular Dynamics Simulations
      24. Larry R. Masterson, Alessandro Cembran, Lei Shi and Gianluigi Veglia

      25. Using a Combination of Computational and Experimental Techniques to Understand the Molecular Basis for Protein Allostery

        Wanting Jiao and Emily J. Parker
     
     

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