Endosome Signalling Part B, 1st Edition

Endosome Signalling Part B, 1st Edition,P. Michael Conn,ISBN9780123979254

Methods in Enzymology

P Conn   

Academic Press




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Continues the legacy of this premier serial with quality chapters authored by leaders in the field

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Key Features

  • Continues the legacy of this premier serial with quality chapters authored by leaders in the field
  • Covers endosome signaling
  • Contains chapters on such topics as measurement of biological effects of endosomal proteolysis of internalized insulin and multi-vesicular endosome biogenesis.


This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This is the second of two volumes on endosome signaling and includes chapters on such topics as measurement of entry into the endosomal compartment by multi-parametric image analysis, assessment of peptide internalization and endosomal signaling, and VEGF-A in endosomal signaling.


Biochemists, biophysicists, molecular biologists, analytical chemists, and physiologists

P. Michael Conn

P. Michael Conn is the Senior Vice President for Research and Associate Provost, Texas Tech Health Sciences Center. He is The Robert C. Kimbrough, Professor of Internal Medicine and Cell Biology/Biochemistry. He was previously Director of Research Advocacy and Professor of Physiology and Pharmacology, Cell Biology and Development and Obstetrics and Gynecology at Oregon Health and Science University and Senior Scientist of the Oregon National Primate Research Center (ONPRC). He served for twelve years as Special Assistant to the President and Associate Director of the ONPRC. After receiving a B.S. degree and teaching certification from the University of Michigan (1971), a M.S. from North Carolina State University (1973), and a Ph.D. degree from Baylor College of Medicine (1976), Conn did a fellowship at the NIH, then joined the faculty in the Department of Pharmacology, Duke University Medical Center where he was promoted to Associate Professor in 1982. In 1984, he became Professor and Head of Pharmacology at the University of Iowa College of Medicine, a position he held for eleven years. Conn is known for his research in the area of the cellular and molecular basis of action of gonadotropin releasing hormone action in the pituitary and therapeutic approaches that restore misfolded proteins to function. His work has led to drugs that have benefitted humans and animals. Most recently, he has identified a new class of drugs, pharmacoperones, which act by regulating the intracellular trafficking of receptors, enzymes and ion channels. He has authored or co-authored over 350 publications in this area and written or edited over 200 books, including texts in neurosciences, molecular biology and endocrinology. Conn has served as the editor of many professional journals and book series (Endocrinology, Journal of Clinical Endocrinology and Metabolism, Endocrine, Methods, Progress in Molecular Biology and Translational Science and Contemporary Endocrinology). Conn served on the National Board of Medical Examiners, including two years as chairman of the reproduction and endocrinology committee. The work of his laboratory has been recognized with a MERIT award from the NIH, the J.J. Abel Award of the American Society for Pharmacology and Experimental Therapeutics, the Weitzman, Oppenheimer and Ingbar Awards of the Endocrine Society, the National Science Medal of Mexico (the Miguel Aleman Prize) and the Stevenson Award of Canada. He is the recipient of the Oregon State Award for Discovery, the Media Award of the American College of Neuropsychopharmacology and was named a distinguished Alumnus of Baylor College of Medicine in 2012. Conn is a previous member of Council for the American Society for Cell Biology and the Endocrine Society and is a prior President of the Endocrine Society, during which time he founded the Hormone Foundation and worked with political leadership to heighten the public’s awareness of diabetes. Conn’s students and fellows have gone on to become leaders in industry and academia. He is an elected member of the Mexican Institute of Medicine and a fellow of the American Association for the Advancement of Science. He is the co-author of The Animal Research War (2008) and many articles for the public and academic community on the value of animal research and the dangers posed by animal extremism. His op/eds have appeared in The Washington Post, The LA Times, The Wall Street Journal, the Des Moines Register, and elsewhere. Conn consults with organizations that are influenced by animal extremism and with universities and companies facing challenges from these groups.

Affiliations and Expertise

Texas Tech University Health Sciences Center, Lubbock, USA

View additional works by P. Michael Conn

Endosome Signalling Part B, 1st Edition

1. Measurement of insulin proteolysis and assessment of insulin-mediated signaling (events) in (liver) endosomes
  Francois Authier
2. Endosomal sorting and implication for signaling
  Eric C. Chang
3. TGF-beta in endosomal signaling
  Gianni M. Di Guglielmo
4. Annexin A6 and endosomal signaling
  Carlos Enrich
5. PI-3-P in endosomal signaling
  Marco Falasca
6.Endosomal signaling and cell migration
  Lukas A. Huber
7. Measuring lipid-ginding effectors in endosomal signaling
  Shiv D. Kale
8. Measuring role for endosomal signaling in tumorigenesis
  Stephanie Kermorgant
9. Measurement of endosomal signaling in the immune system
  Bénédicte Manoury
10. Assessment of the TLR3 pathway in endosomal signaling
  Misako Matsumoto
11. Labeling of platelet-derived growth factor to study its endocytosis and signaling
  Marta Miaczynska
12. Endosomal signaling and oncogenesis
  Ian G. Mills
13. ROS - Containing endosomal compartments: implications for signaling
  Jessica G. Moreland
14. ERBIN in endosomal signaling
  Carol Murphy
15. Lipid raft in endosomal signaling
  Masato Okada
16. VEGF-A in endosomal signaling
  Sreenivasan Ponnambalam
17. Assessment of peptide internalization and endosomal signaling
  Barry I. Posner
18. Quantitative proteomic analysis of compartmentalized signaling networks
  Ian A. Prior
19. Death signaling endosomes: sequential activation of Caspase-8, Caspase-9, acid sphingomyelinase and Cathepsin D in internalized TNF-receptosomes
  Stefan Schütze
20. Deubiquitinases and their emerging roles in cell signaling
  Sudha K. Shenoy
21. NF-kB-dependent pathway in human keratinocytes
  Toshiro Takai
22. Endosomal signaling by the G protein coupled PARs
  JoAnn Trejo
23. Investigating signaling consequences of GPCR trafficking in the endocytic pathway
  Mark von Zastrow
24. MICAL-L1 in endosomal signaling
  Ahmed Zahraoui

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