Toxicogenomics-Based Cellular Models

Toxicogenomics-Based Cellular Models, 1st Edition

Alternatives to Animal Testing for Safety Assessment

Toxicogenomics-Based Cellular Models, 1st Edition,ISBN9780123978622

Academic Press




235 X 191

An authoritative resource based on real examples and current research for the application of toxicogenomics to developing alternatives to animal toxicity tests

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Key Features

  • Describes the state-of-the-art in developing toxicogenomics-based cellular models for chemical-induced carcinogenicity, immunotoxicity, developmental toxicity, neurotoxicity and reproduction toxicity
  • Illustrates how to validate toxicogenomics-based alternative test models and provides an outlook to societal and economic implementation of these novel assays
  • Includes an overview of current testing methods and risk assessment frameworks
  • Provides a real-world assessment by articulating the current development and challenges in toxicogenomics while suggesting ways to move this field forward


Toxicogenomics-Based Cellular Models is a unique and valuable reference for all academic and professional researchers employing toxicogenomic methods with respect to animal testing for chemical safety. This resource offers cutting-edge information on the application of toxicogenomics to developing alternatives to current animal toxicity tests. By illustrating the development of toxicogenomics-based cellular models for critical endpoints of toxicity and providing real-world examples for validation and data analysis, this book provides an assessment of the current state of the field, as well as opportunities and challenges for the future. Written by renowned international toxicological experts, this book explores ‘omics technology for developing new assays for toxicity testing and safety assessment and provides the reader with a focused examination of alternative means to animal testing.


Scientists, academics and students within the fields of toxicology and molecular biology, as well as regulatory authorities involved in chemical safety

Toxicogenomics-Based Cellular Models, 1st Edition

Chapter 1. Introduction and scoping
Chapter 2. Genotoxicity and carcinogenesis
Chapter 3. Immunotoxicity 
Chapter 4. Reproduction Toxicity
Chapter 5. Organ Toxicity
Chapter 6. Toxicoinformatics
Chapter 7. Validating Toxicogenomics Assays
Chapter 8. Implementation Outlook

Quotes and reviews

"Researchers in genetics, toxicology, and other medical and public health specialties describe the current progress in developing toxicogenomics-based cellular models for chemical-induced carcinogenicity, immunotoxicity, and reproductive toxicity, all important endpoint of toxicity, the evaluation of which now costs large numbers of animal lives."--ProtoView.com, April 2014

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