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Inflammation, Advancing Age and Nutrition
 
 

Inflammation, Advancing Age and Nutrition, 1st Edition

Research and Clinical Interventions

 
Inflammation, Advancing Age and Nutrition, 1st Edition,Irfan Rahman,Debasis Bagchi,ISBN9780123978035
 
 
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Rahman   &   Bagchi   

Academic Press

9780123978035

9780123978073

394

276 X 216

Understand the role of dietary polyphenols, antioxidants, selected nutraceuticals and healthy foods in regulating age-related inflammation.

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Key Features

  • Includes models of aging, including worm, mouse and human
  • Explores the relationship of inflammation with diseases, including ocular health, Alzheimer's and Parkinson's disease, and muscle health
  • Encompasses a variety of lifestyle impacts, including diet, exercise and nutrition
  • Includes suggested nutritional interventions

Description

The book provides a comprehensive overview to understanding the integrated impact of the concepts of cellular and molecular aspects, models, environmental factors, and lifestyle involved in premature aging. Additionally, it examines how functional food, dietary nutraceuticals or pharmacological compounds can reverse inflammation and premature aging based on personalized medicine. This book is a valuable resource for health professionals, scientists and researchers, nutritionists, health practitioners, students and for all those who wish to broaden their knowledge in the allied field.

Readership

Researchers, scientists and physicians specializing in arthritis, obesity, diabetes, hypertension, osteoporosis and osteoarthritis, and cardiovascular fields. Gerontologists and Geriatricians. Nutritionists and Dieticians.

Information about this author is currently not available.

Debasis Bagchi

Debasis Bagchi, PhD, MACN, CNS, MAIChE, received his Ph.D. in Medicinal Chemistry in 1982. He is a Professor in the Department of Pharmacological and Pharmaceutical Sciences at the University of Houston College of Pharmacy, Houston, TX, and Chief Scientific Officer at Cepham Research Center, Piscataway, NJ, Adjunct Faculty in Texas Southern University, Houston, TX. He served as the Senior Vice President of Research & Development of InterHealth Nutraceuticals Inc, Benicia, CA, from 1998 till Feb 2011, and then as Director of Innovation and Clinical Affairs, of Iovate Health Sciences, Oakville, ON, till June 2013. Dr. Bagchi received the Master of American College of Nutrition Award in October 2010. He is the Past Chairman of International Society of Nutraceuticals and Functional Foods (ISNFF), Past President of American College of Nutrition, Clearwater, FL, and Past Chair of the Nutraceuticals and Functional Foods Division of Institute of Food Technologists (IFT), Chicago, IL. He is serving as a Distinguished Advisor on the Japanese Institute for Health Food Standards (JIHFS), Tokyo, Japan. Dr. Bagchi is a Member of the Study Section and Peer Review Committee of the National Institutes of Health (NIH), Bethesda, MD. Dr. Bagchi has 315 papers in peer reviewed journals, 27 books and 18 patents. Dr. Bagchi is also a Member of the Society of Toxicology, Member of the New York Academy of Sciences, Fellow of the Nutrition Research Academy, and Member of the TCE stakeholder Committee of the Wright Patterson Air Force Base, OH. Dr. Bagchi is the Associate Editors of the Journal of Functional Foods, Journal of the American College of Nutrition, and Archives of Medical and Biomedical Research, and also serving as Editorial Board Member of numerous peer reviewed journals, including Antioxidants & Redox Signaling, Cancer Letters, Toxicology Mechanisms and Methods, The Original Internist, and other peer reviewed journals.

Affiliations and Expertise

Department of Pharmacological and Pharmaceutical Sciences, University of Houston College of Pharmacy, TX, USA

View additional works by Debasis Bagchi

Inflammation, Advancing Age and Nutrition, 1st Edition

Dedication

Biography

Preface

Contributors

Chapter 1. Biomarkers and Inflammatory Network in Aging: Targets for Therapies

Abstract

Introduction

Aging Biomarkers: Definition and Selection Criteria

Inflammatory Network: A Description and its Biological Effects on Aging

Cellular Inflammatory Biomarkers

Serum Inflammatory Biomarkers

Molecules and Mechanisms Linked to THE NF-κB Signaling System are Potential Targets for Anti-Aging and Anti-Age-Related Disease Treatment Strategies

Conclusions

References

Chapter 2. The Biological Significance of Zinc in Inflammation and Aging

Abstract

Acknowledgments

Introduction

Inflammation, Cellular and Tissue Damage, and Chronic Disease

Reactive Oxygen Species and their Physiological Roles

Reactive Oxygen Species and Cell or Tissue Injury

The Biology of Aging

Aging, Inflammation, Oxidative Stress, and Dna Damage

The Biological Functions of Zinc

The Role of Zinc as an Anti-Inflammatory Agent

Zinc as an Antioxidant Agent

The Molecular Link Between NF-κB, A20, Zinc, And Cancer

The Role of Zinc in The Regulation of Nrf2, Aging, and Cancer

The Role of Zinc in the Regulation of p53 and Cancer

Conclusions and Perspectives

References

Chapter 3. Immunity, Inflammation, and Aging

Abstract

Introduction

Aging and Immune System Remodeling

Aging and Inflammation

Summary and Conclusions

References

Chapter 4. Oxidative Stress, Inflammaging, and Immunosenescence

Abstract

Introduction

Inflammaging

Roles of Oxidative and Inflammatory Stress in Immunosenescence

The Oxidation-Inflammation Theory of Aging

Role of Antioxidants in the Immune System

Chronic Stress Leads to Premature Immunosenescence and Increased Inflammaging

Conclusions

References

Chapter 5. Stress Response, Inflammaging, and Cancer

Abstract

Introduction

Inflammation and Cancer

Inflammaging in Carcinogenesis

Phytochemicals as Chemopreventive Agents

References

Chapter 6. Aging, Immunosenescence, and Cancer

Abstract

Acknowledgments

Introduction

The Definition of Aging

Aging and Cancer

Immune System and Cancer

Immunosenescence and Inflammaging

Immunosenescence and Cancer

Modulation

Conclusions

References

Chapter 7. Telomere Biology in Senescence and Aging: Focus on Cardiovascular Traits

Abstract

Acknowledgments

Introduction

Telomere Biology and Its Link to Cellular Senescence

Telomere/Telomerase and Aging

The Axis of Aging: Telomere-P53-Mitochondria

Factors Influencing Telomere Length

Factors Influencing Telomerase

Telomere Biology in Stem Cells

Telomere Biology and Cardiovascular Traits

Telomere Biology and Diabetes

Perspectives

References

Chapter 8. Epigenetics, Inflammation, and Aging

Abstract

Introduction

Epigenetics and the Fetal Origin of Adult Diseases

Mechanisms Involved in Dietary and Nutritional Modulation of DNA Methylation and Histone Modifications

Dietary Influence on Epigenetics During Early Development

Influence of Dietary Components on Epigenetic Marks in Developed Organisms

Epigenetic Changes to the Immune System that Lead to Inflammation and Disease

Conclusions

References

Chapter 9. Nutrition as an Epigenetic Modifier in Aging and Autoimmunity

Abstract

Introduction

Epigenetics and Aging

Environmental Stressors, Epigenetics, and Autoimmunity

Epigenetics in Different Autoimmune Diseases

Diet, DNA Methylation, and Immune-Mediated Diseases

Lifetime Diet

Conclusions

References

Chapter 10. Connecting Phytochemicals, Epigenetics, and Healthy Aging: Is Metabolism the Missing Link?

Abstract

Acknowledgments

Introduction

Crosstalk of Inflammation and Energy Metabolism Fuel Epigenetic Plasticity

Nutriepigenomics: Lifelong Remodeling of Our Epigenomes By Nutritional, Phytochemical, and Metabolic Factors

Xenohormetic Epigenetic Effects of Plant Secondary Metabolites Across Species: An Evolutionary Role for Stress Adaptive Responses in Healthy Aging and Longevity

Conclusion

References

Chapter 11. Diet/Nutrition, Inflammation, Cellular Senescence, Stem Cells, Diseases of Aging, and Aging

Abstract

Introduction: The Effect of Evolution of the Physical World on the Evolution of the Biological World

Evolutionary Transition from an Anoxic Environment to an Aerobic Environment: Mitochondria, Asymmetric Cell Division, Stem Cells, and Metazoans

Aging of the Organism

How the Study of Human Carcinogenesis Might Assist in Unraveling Aging: The Role of Stem Cells, Cell-Cell Communication, Diet, and Inflammation in the Multistage, Multi-Mechanism Process of Carcinogenesis

What is the Origin of the Initiated Cell?

Role of Oxygen in the Homeostatic Regulation of Stem Cells

Stem Cells, The Warburg Hypothesis, and Cancer

Roles of Nutrition/Diet and Inflammation in the Different Phases of Carcinogenesis

Stem Cells and Aging

Cellular Senescence: The End of Cellular Life Span or Only a Reversible, Transient Epigenetic Quiescent Stage of the Cell’s Life?

Summary

References

Chapter 12. Circadian Clock Mechanisms Link Aging and Inflammation

Abstract

Introduction

The Circadian System and Rhythms

Molecular Mechanisms of the Circadian Clock

Circadian Clock Disruption and Aging

Mechanisms of the Circadian Clock and Aging

Circadian Clock and Inflammation

Conclusions and Perspectives

References

Chapter 13. Obesity, Insulin Resistance, and Inflammaging

Abstract

Abbreviations

Introduction

Inflammatory Mediators, Obesity, and Aging

CrossTalk between Insulin and Inflammatory Signaling

Adipose Tissue Macrophages

Role of Other Immune Cell Types in Obesity-Associated Inflammaging

Therapeutic Options

Conclusion

References

Chapter 14. Organelle Stress and mTOR in Aging-Associated Inflammation

Abstract

Abbreviations

Introduction

Turning Cellular Stress into Inflammation: Endoplasmic Reticulum and Mitochondria

mTOR in Nutrient Sensing and Aging

mTOR Routes to Inflammation

mTOR, Inflammation, and “Hypertrophic” Aging

mTOR and Cellular Senescence

mTOR and Stem Cell Aging

mTOR, Obesity, and “Metainflammation”

Hypertrophy Versus Atrophy, mTOR, and Muscle Aging

Concluding Remarks: Aging and mTOR-Dependent Repair

References

Chapter 15. SIRT1 and Inflammaging in Chronic Obstructive Pulmonary Disease

Abstract

Acknowledgments and Disclosures

Introduction

Inflammaging in COPD

Abnormal Cellular Processes During Inflammaging in COPD

SIRT1 and Inflammaging

SIRT1 Agonists/Activators: Anti-Inflammaging Molecules

Conclusions

References

Chapter 16. Stress-Induced Premature Senescence: Another Mechanism Involved in the Process of Accelerated Aging in Chronic Obstructive Pulmonary Disease

Abstract

Introduction

Inflammaging and Cellular Senescence: Basic Characteristics

Inflammaging and Oxidative Stress in COPD

Stress-Induced Premature Senescence Under Oxidative Stress in COPD

Functions of Stress-Induced Premature Senescence Overlap with Inflammaging in COPD

COPD in a Human Model with Prematrue Aging Features Related to Inflammaging or Stress-Induced Premature Senescence

Role of Inflammaging in Extrapulmonary Manifestations of COPD

Unresolved Questions

References

Chapter 17. Cellular Senescence and Premature Aging in Lung Diseases

Abstract

Why Do Senescence- and Elderly-Specific Diseases Develop?

Cellular Senescence Associated with Aging and Illness Often Seen in Elderly People

COPD

Pulmonary Fibrosis

Differences in the Cellular Senescence Underlying the Onset of Pulmonary Emphysema and Fibrosis

Conclusions

References

Chapter 18. Rheumatoid Arthritis: Disease Pathophysiology

Abstract

Abbreviations

Introduction

T Cells in Rheumatoid Arthritis

B Cells and Autoantibodies

Cytokines in Rheumatoid Arthritis

Cartilage/Bone Destruction

Conclusions

References

Chapter 19. Aging and Anti-Aging in Hair and Hair Loss

Abstract

Introduction

Mechanisms in the Aging of Hair Follicles

Chronic Inflammation in the Pathogenesis of Hair Diseases

Anti-Aging

Conclusion

References

Chapter 20. Muscle Wasting, Dysfunction, and Inflammaging

Abstract

Introduction

Age-Related Changes in Skeletal Muscle

Disability Threshold

Causes of Age-Related Muscle Dysfunction

Exercise

Conclusion

References

Chapter 21. Matrix Metalloproteinases and Skin Inflammaging

Abstract

Introduction

Matrix Metalloproteinases and Skin-Intrinsic Aging

Matrix Metalloproteinases and Skin Photoaging

Matrix-Directed Skin Inflammaging

Concluding Remarks: Skin Inflammaging Proteases and Cutaneous Disorders in Elderly Persons

References

Chapter 22. Ocular Health, Vision, and a Healthy Diet

Abstract

Introduction

Ocular Inflammatory Diseases

Age-Related Ocular Diseases

Management of Ocular Diseases to Promote Healthy Vision

Conclusions and Perspectives

References

Chapter 23. The Role of Physical Activity in Healthy Living: Its Anti-Inflammatory Effects

Abstract

Introduction

Daily Physical Activity Recommendations

Overweight and Obesity

Type 2 Diabetes

Metabolic Syndrome

Hypertension

Hyperlipidemia

Inflammation

Review of the Evidence on the Effect of Exercise on Inflammatory Markers

References

Chapter 24. Erectile Dysfunction in Inflammaging

Abstract

Introduction

Prevalence and Etiology

Pathophysiology of Erectile Dysfunction in the Aging Man

Assessment

Treatment

Conclusions

References

Chapter 25. Role of Saturated and Polyunsaturated Fat in Obesity-Related Inflammation

Abstract

Introduction

Intracellular Fatty Acid Metabolism

Polyunsaturated Fatty Acids as Precursors of Pro- and Anti-Inflammatory Mediators

The Cellular and Molecular Basis of Inflammation

Mechanisms of Obesity-Related Low-Grade Inflammation

Role of Different Fatty Acid Types on Low-Grade Inflammation

Concluding remarks

References

Chapter 26. Cellular Stress Response, Hormesis, and Vitagens in Aging and Longevity: Role of mitochondrial “Chi”

Abstract

Acknowledgments

Introduction

Cellular Stress Response, Heat Shock Transcription Factor Biology, and the Vitagene Network

The Mitochondrial Theory of Aging

Hormesis

Conclusions and Future Directions

References

Chapter 27. Inflammaging Signaling in Health Span and Life Span Regulation: Next Generation Targets for Longevity

Abstract

Acknowledgments

Introduction

Inflammaging

Signaling Network Controlling the Aging Process

Dietary Restriction and Extension of Life Span

Potential Targets for Anti-Aging Medicine

Magic Bullets Without Potency

Conclusions

References

Chapter 28. Trophokines: Novel Therapy for Senescence-Related Fibrosis

Abstract

Introduction

Potential Clinical Applications of Trophokines

Preclinical Progress with Therapeutic Trophokines

Summary: HGF-FC/MSP-FC Fusion Provides a Possible New Therapeutic Antifibrotic Agent

References

Chapter 29. Frailty: A Basic and Clinical Challenge for the Future

Abstract

Introduction

Challenges Raised by Frailty

References

Index

Quotes and reviews

"The goal is to find pharmacological compounds or dietary polyphenals to treat chronic inflammation, cellular senescence, and premature aging. Scientists from many biomedical specialties review the current concepts and knowledge in the matter, emphasizing cellular and molecular aspects using in vitro cell cultures and in vivo animal and human models. The topics include the biological significance of zinc in inflammation and aging,…"--ProtoView.com, February 2014

 
 
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