Optical Coherence Tomography

Optical Coherence Tomography, 2nd Edition

Principles and Applications

Optical Coherence Tomography, 2nd Edition,Mark E. Brezinski,ISBN9780123969644





229 X 152

The most comprehensive guide to applications and market issues related to this important high-resolution imaging technology

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Key Features

  • Revised throughout, comprehensive guide to optical coherence tomography (OCT), including the most recent research in context and thoroughly explained
  • Provides non-scientists and non-engineers with a basic understanding of OCT applications and issues
  • Written by one of the pioneers of OCT


OCT is a medical high-resolution imaging technology that offers several distinct advantages over current medical imaging technologies. With a resolution 25x greater than current technologies, its ability to be engineered very small due to its fiber-based design, and it is high speed with frame rates close to video rates, this technology is attracting many researchers.

This second edition brings together information needed by the various, and sometimes disparate, groups using and studying this technology. It is completely updated throughout with the most recent research and applications. This is not a book on how to build OCT devices, but rather gives a broad treatment of the subject including 1) the optics, science, and physics needed to understand the technology; 2) a description of applications with a critical look at how the technology will successfully address actual clinical need; and 3) a discussion of delivery of OCT to the patient, FDA approval and comparisons with available competing technologies.

While the required mathematical rigor is present where needed, it is presented in such a way that non-scientists and non-engineers will be able to gain a basic understanding of OCT its applications, as well as the issues of bringing the technology to the market.


Optical engineers; biomedical and clinical scientists; clinicians; medical doctors; researchers; manufacturers of OCT devices.

Mark E. Brezinski

Affiliations and Expertise

Brigham & Women’s Hospital, Boston, MA; Massachusetts Institute of Technology, Cambridge, MA, USA

Optical Coherence Tomography, 2nd Edition


Section I:

Chapter 1. The Basics (math, waves, etc.) for the Nonphysical Scientist

Chapter 2. Light and Electromagnetic Waves

Chapter 3. Light in Matter

Chapter 4. Interference, Coherence, Diffraction, and Transfer Functions

Section II:

Chapter 5. Optical Coherence Tomography Theory

Chapter 6. Optoelectronics And Optical Components

Chapter 7. Noise and System Performance with TD-OCT and SD-OCT

Chapter 8. Polarization and Polarization Sensitive OCT (PS-OCT)

Chapter 9. Adjuvant Techniques: Absorption Spectroscopy, Contrast Probes, Phase Contrast, Elastography, and Entangled Photons

Chapter 10. Doppler Optical Coherence Tomography

Chapter 11. Digital Image Processing Techniques for Speckle Reduction, Enhancement and Segmentation of Optical Coherence Tomography (OCT) Images

Section III

Chapter 12. Application of OCT to Clinical Imaging: Introduction

Chapter 13. Other Technologies

Chapter 14. Introduction to Clinical Research Design and Analysis

Chapter 15. OCT in Cardiovascular Medicine

Chapter 16. OCT in Musculoskeletal Disease

Chapter 17. OCT in Oncology

Chapter 18. Other Applications and Conclusions


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