Optical Coherence Tomography

Optical Coherence Tomography, 2nd Edition

Principles and Practice

Optical Coherence Tomography, 2nd Edition,Mark E. Brezinski,ISBN9780123969644
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This text is the most comprehensive guide to applications and market issues related to this important, high-resolution imaging technology

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Key Features

  • Revised, comprehensive guide to optical coherence tomography (OCT), including thoroughly explained recent research
  • Presents a broad treatment of the subject, including its optics, science, and the physics needed to understand the technology
  • Includes a description of applications with a critical look on how the technology will address actual clinical needs
  • Provides non-scientists and non-engineers with a basic understanding of OCT applications and issues.
  • Written by a pioneer of optical coherence tomography


Optical Coherence Tomography, Principles and Applications, Second Edition provides the latest information on OCT, a high-resolution medical imaging technology that offers several distinct advantages over current medical imaging technologies.

This second edition brings together the most updated information needed by a wide variety of groups using and studying this technology. It is completely updated throughout with the most recent research and applications. The text does not demonstrate how to build OCT devices, but instead gives a broad treatment of the subject, including its optics, science, and the physics needed to understand the technology, a description of applications with a critical look on how the technology will successfully address actual clinical needs, a discussion of delivery of OCT to the patient, and FDA approval and comparisons with available competing technologies.

The required mathematical rigor is presented in such a way that non-scientists and non-engineers will be able to gain a basic understanding of OCT and its further applications


Optical engineers; biomedical and clinical scientists; clinicians; medical doctors; researchers; manufacturers of OCT devices.

Mark E. Brezinski

Affiliations and Expertise

Brigham & Women’s Hospital, Boston, MA; Massachusetts Institute of Technology, Cambridge, MA, USA

Optical Coherence Tomography, 2nd Edition


Section I:

Chapter 1. The Basics (math, waves, etc.) for the Nonphysical Scientist

Chapter 2. Light and Electromagnetic Waves

Chapter 3. Light in Matter

Chapter 4. Interference, Coherence, Diffraction, and Transfer Functions

Section II:

Chapter 5. Optical Coherence Tomography Theory

Chapter 6. Optoelectronics And Optical Components

Chapter 7. Noise and System Performance with TD-OCT and SD-OCT

Chapter 8. Polarization and Polarization Sensitive OCT (PS-OCT)

Chapter 9. Adjuvant Techniques: Absorption Spectroscopy, Contrast Probes, Phase Contrast, Elastography, and Entangled Photons

Chapter 10. Doppler Optical Coherence Tomography

Chapter 11. Digital Image Processing Techniques for Speckle Reduction, Enhancement and Segmentation of Optical Coherence Tomography (OCT) Images

Section III

Chapter 12. Application of OCT to Clinical Imaging: Introduction

Chapter 13. Other Technologies

Chapter 14. Introduction to Clinical Research Design and Analysis

Chapter 15. OCT in Cardiovascular Medicine

Chapter 16. OCT in Musculoskeletal Disease

Chapter 17. OCT in Oncology

Chapter 18. Other Applications and Conclusions

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