Volume 503: Protein Engineering for Therapeutics, Part B, 1st Edition

Key Features

Description

This volume of Methods in Enzymology looks at Protein Engineering for Therapeutics. The chapters provide an invaluable resource for academics, researchers and students alike. With an international board of authors, this volume is split into sections that cover subjects such as Peptides, and Scaffolds

Protein Engineering for Therapeutics, Part B, 1st Edition

Part III: Peptides

1. Stapled Peptides for Intracellular Drug Targets

Gregory L. Verdine and Gerard J. Hilinski

2. Mapping of vascular zip codes by phage display

Tambet Teesalu, Kazuki N. Sugahara & Erkki Ruoslahti

3. Engineering cyclic peptide toxins

Richard J. Clark and David J. Craik

4. Peptide Discovery using Bacterial Display and Flow Cytometry

Jennifer A. Getz, Tobias D. Schoep, Patrick S. Daugherty

Part V: Scaffolds

5. Designed Ankyrin Repeat Proteins (DARPins): From research to therapy

Rastislav Tamaskovic, Manuel Simon, Nikolas Stefan, Martin Schwill and Andreas Plückthun

6. Target-binding proteins based on the tenth human fibronectin type III domain (¹⁰Fn3)

Shohei Koide, Akiko Koide, and Daša Lipovšek

7. Anticalins: small engineered binding proteins based on the lipocalin scaffold

Michaela Gebauer and Arne Skerra

8. T Cell Receptor Engineering

Jennifer D. Stone, Adam S. Chervin, David H. Aggen, David M. Kranz

9. Engineering Knottins as Novel Binding Agents

Sarah J. Moore and Jennifer R. Cochran

Part VI: Pharmacokinetics

10. Practical Theoretic Guidance for the Design of Tumor Targeting Agents

K. Dane Wittrup, Greg M. Thurber, Michael M. Schmidt, John J. Rhoden

11. Re-Engineering Biopharmaceuticals for Targeted Delivery Across the Blood-Brain Barrier

William M. Pardridge and Ruben J. Boado

12. Engineering and Identifying Supercharged Proteins for Macromolecule Delivery into Mammalian Cells

David B. Thompson, James J. Cronican, and David R. Liu