Hedgehog Signaling, 1st Edition

Hedgehog Signaling, 1st Edition,Gerald Litwack,ISBN9780123946225

Vitamins and Hormones

G Litwack   

Academic Press




229 X 152

Cutting-edge review concerning the molecular and cellular biology of vitamins and hormones.

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Key Features

Key features:

* Contributions from leading authorities
* Informs and updates on all the latest developments in the field


First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press.

Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.

This volume focuses on hedgehog signaling.


Researchers, faculty, and graduate students interested in cutting-edge review concerning the molecular and cellular biology of vitamins, hormones, and related factors and co-factors. Libraries and laboratories at institutes with strong programs in cell biology, biochemistry, molecular biology, gene regulation, hormone control, and signal transduction are likely to be interested.

Gerald Litwack

Following a liberal arts education with a major in chemistry and biology at Hobart College, Gerald (Gerry) Litwack earned M.S. and PhD degrees in biochemistry from the University of Wisconsin, Madison where he served as a Lecturer in Enzymology before starting a postdoctoral fellowship from the National Foundation for Infantile Paralysis at the Biochemical Institute of the Sorbonne in Paris. His first academic position was assistant professor of biochemistry at Rutgers University where he started his work on hormone action for six years. During this period, he did a sabbatical at the University of California, Berkeley, where he concentrated on rapid enzyme kinetics. In 1960 he accepted an offer of an associate professorship at the University of Pennsylvania Graduate School of Medicine. In 1964, he was invited to be full professor of biochemistry at The Fels Institute for Cancer Research and Molecular Biology at Temple Medical School, simultaneously with a Career Development Award from the NIH, where he later was named Deputy Director of the Institute and the Laura H. Carnell Professor in biochemistry. Subsequently, he was given the Faculty Research Award. He co-discovered ligandin, later found to be in the family of glutathione S-transferases, enzymes that protect the body from carcinogens. In 1991, he moved to the Jefferson Medical College at Thomas Jefferson University as Professor of Biochemistry, Chair of the Department of Pharmacology and Deputy Director of the Kimmel Cancer Research Institute. Later, he became chair of the combined Department of Biochemistry and Molecular Pharmacology and concurrently held the position of Vice Dean for Research. In 2003, he moved to Los Angeles and from 2004-2006 was a Visiting Scholar at the University of California, Los Angeles, in the Department of Biological Chemistry of the Geffen School of Medicine and, in this period, wrote “Human Biochemistry and Disease” a volume of 1254 pages. In 2007, he moved to Scranton, Pennsylvania, as Founding Chair of Basic Sciences and Acting Associate Dean for Research to start a new medical school, The Commonwealth Medical College. Having completing his mission in 2010, he moved to The Institute for Regenerative Medicine, Texas A & M Health Science Center, as Professor of Biochemistry and Associate Director. Currently, he is retired and lives in North Hollywood, California, where he continues as an author and as Series Editor of Vitamins and Hormones. He is involved in writing another textbook and has written a first novel, “One-Eighty”.

Affiliations and Expertise

Toluca Lake, North Hollywood, California, USA

View additional works by Gerald Litwack

Hedgehog Signaling, 1st Edition

  1. Hedgehog Signaling
  2. Siu Wah Choy, Shuk Han Cheng

  3. Canonical and Non-Canonical Hedgehog/GLI Signaling in Hematological Malignancies
  4. Fritz Aberger, Daniela Kern, Richard Greil and Tanja Nicole Hartmann

  5. Non-Canonical Hedgehog Signaling
  6. Donna Brennan, Xiaole Chen, Lan Cheng, My Mahoney, and Natalia A Riobo

  7. Gli Protein Nuclear Localization Signal
  8. Minoru Hatayama and Jun Aruga

  9. Mammalian Homologues of Drosophila Fused Kinase
  10. Alla Maloverjan and Marko Piirsoo

  11. Identification, Functional Characterization and Pathobiological Significance of GLI1 Isoforms in Human Cancers
  12. Richard L. Carpenter, Hui-Wen Lo

  13. Gli-Similar (Glis) Proteins: Their Mechanisms of Action, Physiological Functions, and Roles in Disease
  14. Kristin Lichti-Kaiser, Gary ZeRuth, Hong Soon Kang, Shivakumar Vasanth, and Anton M. Jetten

  15. Sonic Hedgehog Regulates Wnt Activity During Neural Circuit Formation
  16. Nicole H. Wilson and Esther T. Stoeckli

  17. Hedgehog/Gli Control by Ubiquitination/Acetylation Interplay
  18. Alberto Gulino, Lucia Di Marcotullio, Gianluca Canettieri, Enrico Desmaele, Isabella Screpanti

  19. Palmitoylation of Hedgehog Proteins
  20. John A. Buglino and Marilyn D. Resh

  21. Phosphorylation Regulation of Hedgehog Signaling
  22. Jianhang Jia

  23. Protein Kinase A Activity and Hedgehog Signaling Pathway
  24. Tomoya Kotani

  25. Phosphorylation of Gli by Camp-Dependent Protein Kinase
  26. Yoshinari Asaoka

  27. ZFP932 Suppresses Cellular Hedgehog Response and Patched1 Transcription
  28. G. Jason Huang, Zhenhua He and Liang Ma

  29. A New Era for an Ancient Drug; Arsenic Trioxide and Hedgehog Signaling
  30. Elspeth M. Beauchamp and Aykut Üren

  31. Aberrations and Therapeutics Involving the Developmental Pathway Hedgehog in Pancreatic Cancer
  32. Fergal Crothur Kelleher

  33. Sonic Hedgehog Signaling and Potential Therapeutic Indications
  34. Nicholas C. Bambakidis, Kaine Onwuzulike

  35. Sonic Hedgehog on Microparticles and Neovascularization
  36. Raffaella Soleti and Maria Carmen Martinez

  37. ‘Patch’-ing Up the Neurons: Revival or Enervation?
  38. Sayantani Ghosh, Arunabha Chakrabarti and Debashis Mukhopadhyay

  39. Activation of Hedgehog Pathway in Gastrointestinal Cancers
  40. Ling Yang, Xiulan Su, Jingwu Xie

  41. The Role Of Sonic Hedgehog as a Regulator of Gastric Function and Differentiation
  42. Rui Feng, Chang Xiao and Yana Zavros

  43. Sonic Hedgehog-Mediated Synergistic Effects Guiding Angiogenesis and Osteogenesis
  44. Sabine Fuchs, Eva Dohle, Charles James Kirkpatrick

  45. Hedgehog Inhibition as an Anti-Cancer Strategy

G. Praveen Raju, and Diane Pham

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