Advances in Immunology

Advances in Immunology, 1st Edition

Advances in Immunology, 1st Edition,Frederick Alt,ISBN9780123943002

Advances in Immunology

F Alt   

Academic Press




229 X 152

This series continually publishes cutting-edge reviews in the field of immunology

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Key Features

  • Contributions from leading authorities
  • Informs and updates on all the latest developments in the field


Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.


Immunologists and infectious disease specialists, cell biologists and hematologists

Frederick Alt

Affiliations and Expertise

Howard Hughes Medical Institute Research Laboratories, The Children's Hospital, Boston, MA, USA

View additional works by Frederick W. Alt

Advances in Immunology, 1st Edition

  • Contributors
  • Chapter One Classical and Alternative End-Joining Pathways for Repair of Lymphocyte-Specific and General DNA Double-Strand Breaks
    • 1 Introduction
    • 2 V(D)J Recombination
    • 3 IgH Class-Switch Recombination
    • 4 Classical Nonhomologous DNA End Joining
    • 5 Alternative End Joining
    • 6 Perspective
  • Chapter Two The Leukotrienes: Immune-Modulating Lipid Mediators of Disease
    • 1 Introduction
    • 2 Biosynthesis of LTs
    • 3 LT Receptors
    • 4 LTs in Immune Responses
    • 5 5-LO and LTs in Human Diseases
    • 6 Antileukotriene Drugs
    • 7 Conclusions
  • Chapter Three Gut Microbiota Drives Metabolic Disease in Immunologically Altered Mice
    • 1 Gut Microbiota: The Organ Within the Organ
    • 2 Localization and Restricted Signaling of PRRs Protects against Aberrant Gut Inflammation
    • 3 Role of Microbiota in Metabolic Disease
    • 4 Increased Energy Harvesting by Microbiota in the Development of Metabolic Disease
    • 5 Microbiota-Induced Sub-Clinical Gut Inflammation Causes Metabolic Disease
    • 6 Microbiota Generates Toxic Metabolites from the Diet, Resulting in Metabolic Disease
    • 7 Microbiota-Mediated Metabolic Disease in Absence of Inflammasome Signaling
    • 8 Microbiota-Mediated Metabolic Disease in Absence of Adaptative Immunity
    • 9 Manipulating the Gut Microbiome, Therapeutic Strategies for Obesity
    • 10 Unanswered Questions, Future Directions, and Conclusions
  • Chapter Four What is Unique About the IgE Response?
    • 1 Effector Functions of IgE Antibodies
    • 2 Control of Class Switch Recombination to IgE
    • 3 Direct and Sequential Switching to IgE
    • 4 IgE+ Cells and Germinal Centers
    • 5 Germinal Center Versus Plasma Cell Fates: Bcl6 and Blimp1
    • 6 Studying IgE Responses In Vivo
    • 7 IgE Cytoplasmic Tail and Germinal Centers
    • 8 Is There a Memory IgE+ Cell?
    • 9 Direct and Sequential Switching to IgE in Immature and Mature B Cells
    • 10 Human Immunodeficiencies with High IgE Production
    • 11 Concluding Remarks
  • Chapter Five Prostanoids as Regulators of Innate and Adaptive Immunity
    • 1 Introduction
    • 2 Prostanoid Receptors
    • 3 Prostanoids and Innate Immunity
    • 4 Prostanoids and Adaptive Immunity
    • 5 Prostanoids in Immunopathology
    • 6 Targeting of Prostanoid Receptors
    • 7 Concluding Remarks
  • Chapter Six Lymphocyte Development: Integration of DNA Damage Response Signaling
    • 1 Lymphocyte Antigen Receptor Gene Assembly
    • 2 DNA Damage Responses
    • 3 Responses to RAG-Mediated DNA DSBs
    • 4 Integrating RAG DSB-Mediated Signals with Other B Lymphocyte Developmental Signals
    • 5 Concluding Remarks
  • Index
  • Contents of Previous Volumes

Quotes and reviews

"The series which all immunologists need." --The Pharmaceutical Journal

"Advances in Immunology must find itself among the most active volumes in the libraries of our universities and institutions." --Science

"Deserves a permanent place in biomedical libraries as an aid in research and in teaching." --Journal of Immunological Methods

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