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Challenges and Opportunities of Next-Generation Sequencing for Biomedical Research
 
 

Challenges and Opportunities of Next-Generation Sequencing for Biomedical Research, 1st Edition

 
Challenges and Opportunities of Next-Generation Sequencing for Biomedical Research, 1st Edition,Mark Rees,ISBN9780123942876
 
 
 

M Rees   

Academic Press

9780123942876

9780123982735

208

229 X 152

Covers reviews of methodology and research in all aspects of protein chemistry. Brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics

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Key Features

  • Covers reviews of methodology and research in all aspects of protein chemistry
  • Brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics

Description

Published continuously since 1944, the Advances in Protein Chemistry and Structural Biology serial has been a continuous, essential resource for protein chemists. Covering reviews of methodology and research in all aspects of protein chemistry, including purification/expression, proteomics, modeling and structural determination and design, each volume brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics. This volume features articles on Challenges and Opportunities of Next-Generation Sequencing for Biomedical Research.

Readership

Biochemists, biophysicists, cell biologists, protein chemists, structural geneticists, and structural biologists

Information about this author is currently not available.

Challenges and Opportunities of Next-Generation Sequencing for Biomedical Research, 1st Edition

  • Preface
  • Chapter One Next Generation Sequencing Methodologies - An Overview
    • 1 Introduction/NGS
    • 2 Sample Submission Strategies
    • 3 Phenotyping Challenges and Strategies
    • 4 Development of NGS Technologies
    • 5 Application of NGS
    • 6 Bioinformatics
  • Chapter Two Next Generation Sequencing in the Clinical Domain: Clinical Advantages, Practical, and Ethical Challenges
    • 1 Introduction
    • 2 What is NGS?
    • 3 Explosion of Exome Sequencing Papers
    • 4 The Successes of Exome Sequencing
    • 5 The Successes of Genome Sequencing
    • 6 Ethics of WES
    • 7 NGS in Routine Clinical Practice?
  • Chapter Three Opportunities and Challenges for Genome Sequencing in the Clinic
    • 1 Introduction
    • 2 Milestones in the Development of Genetic Mapping
    • 3 Strategies for the Application of Next-Generation Sequencing in Genetic Mapping
    • 4 Consequence of Gene Discovery in Research Programs
    • 5 Challenges Around Incorporating Sequencing to the Clinic
  • Chapter Four Polymorphisms in Neuropsychiatric and Neuroinflammatory Disorders and the Role of Next Generation Sequencing in Early Diagnosis and Treatment
    • 1 Polymorphisms in Major Depressive Disorders
    • 2 Polymorphisms in ADHD
    • 3 Polymorphisms in Neuroinflammatory Diseases
    • 4 Multiple Sclerosis
    • 5 Alzheimer’s Disease
    • 6 Parkinson’s Disease
    • 7 Role of the NGS in Early Diagnostic and Treatment
    • 8 Conclusions
  • Chapter Five Structural Modelling Pipelines in Next Generation Sequencing Projects
    • 1 Introduction
    • 2 Protein Structure and Function
    • 3 Structural Modeling Methods
    • 4 Assessing Functional Impact of nsSNPs
    • 5 Protein–Protein Interaction Networks
  • Author Index
  • Subject Index

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