G Protein Coupled Receptors

G Protein Coupled Receptors, 1st Edition

Trafficking and Oligomerization

G Protein Coupled Receptors, 1st Edition,P. Michael Conn,ISBN9780123918628

Methods in Enzymology

P Conn   

Academic Press




229 X 152

This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. It covers G protein coupled receptors and includes chapters on such topics as G protein-coupled receptor trafficking motifs, structure-based virtual screening, and automation-friendly high-throughput assays for identifying pharmacoperone drugs.

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Key Features

  • Continues the legacy of this premier serial with quality chapters authored by leaders in the field
  • Covers G protein coupled receptors
  • Contains chapters on such topics as G protein-coupled receptor trafficking motifs, structure-based virtual screening, and automation-friendly high-throughput assays for identifying pharmacoperone drugs


This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. This volume covers G protein coupled receptors and includes chapters on such topics as G protein-coupled receptor trafficking motifs, structure-based virtual screening, and automation-friendly high throughput assays for identification of pharmacoperone drugs.


Biochemists, biophysicists, molecular biologists, analytical chemists, and physiologists

P. Michael Conn

P. Michael Conn is the Senior Vice President for Research and Associate Provost, Texas Tech Health Sciences Center. He is The Robert C. Kimbrough, Professor of Internal Medicine and Cell Biology/Biochemistry. He was previously Director of Research Advocacy and Professor of Physiology and Pharmacology, Cell Biology and Development and Obstetrics and Gynecology at Oregon Health and Science University and Senior Scientist of the Oregon National Primate Research Center (ONPRC). He served for twelve years as Special Assistant to the President and Associate Director of the ONPRC. After receiving a B.S. degree and teaching certification from the University of Michigan (1971), a M.S. from North Carolina State University (1973), and a Ph.D. degree from Baylor College of Medicine (1976), Conn did a fellowship at the NIH, then joined the faculty in the Department of Pharmacology, Duke University Medical Center where he was promoted to Associate Professor in 1982. In 1984, he became Professor and Head of Pharmacology at the University of Iowa College of Medicine, a position he held for eleven years. Conn is known for his research in the area of the cellular and molecular basis of action of gonadotropin releasing hormone action in the pituitary and therapeutic approaches that restore misfolded proteins to function. His work has led to drugs that have benefitted humans and animals. Most recently, he has identified a new class of drugs, pharmacoperones, which act by regulating the intracellular trafficking of receptors, enzymes and ion channels. He has authored or co-authored over 350 publications in this area and written or edited over 200 books, including texts in neurosciences, molecular biology and endocrinology. Conn has served as the editor of many professional journals and book series (Endocrinology, Journal of Clinical Endocrinology and Metabolism, Endocrine, Methods, Progress in Molecular Biology and Translational Science and Contemporary Endocrinology). Conn served on the National Board of Medical Examiners, including two years as chairman of the reproduction and endocrinology committee. The work of his laboratory has been recognized with a MERIT award from the NIH, the J.J. Abel Award of the American Society for Pharmacology and Experimental Therapeutics, the Weitzman, Oppenheimer and Ingbar Awards of the Endocrine Society, the National Science Medal of Mexico (the Miguel Aleman Prize) and the Stevenson Award of Canada. He is the recipient of the Oregon State Award for Discovery, the Media Award of the American College of Neuropsychopharmacology and was named a distinguished Alumnus of Baylor College of Medicine in 2012. Conn is a previous member of Council for the American Society for Cell Biology and the Endocrine Society and is a prior President of the Endocrine Society, during which time he founded the Hormone Foundation and worked with political leadership to heighten the public’s awareness of diabetes. Conn’s students and fellows have gone on to become leaders in industry and academia. He is an elected member of the Mexican Institute of Medicine and a fellow of the American Association for the Advancement of Science. He is the co-author of The Animal Research War (2008) and many articles for the public and academic community on the value of animal research and the dangers posed by animal extremism. His op/eds have appeared in The Washington Post, The LA Times, The Wall Street Journal, the Des Moines Register, and elsewhere. Conn consults with organizations that are influenced by animal extremism and with universities and companies facing challenges from these groups.

Affiliations and Expertise

Texas Tech University Health Sciences Center, Lubbock, USA

View additional works by P. Michael Conn

G Protein Coupled Receptors, 1st Edition

    GPCR Trafficking

    1. Therapeutic Rescue of Misfolded/Mistrafficked Mutants: Automation-Friendly High Throughput Assays for Identification of Pharmacoperone Drugs of GPCRs
    2. David C. Smithson, Jo Ann Janovick, P. Michael Conn

    3. Trafficking of the Follitropin Receptor
    4. Alfredo Ulloa-Aguirre, James A. Dias, George Bousfield, Ilpo Huhtaniemi, and Eric Reiter

    5. Single Molecule Imaging Technique to Study the Dynamic Regulation of GPCR Function at the Plasma Membrane
    6. B.E. Snaar-Jagalska, A. Cambi, T. Schmidt and S. de Keijzer

    7. GPCR Oligomerization and Receptor Trafficking
    8. Richard J. Ward, Tian-Rui Xu and Graeme Milligan

    9. b-Arrestins and G Protein-Coupled Receptor Trafficking
    10. Dong Soo Kang, Xufan Tian, and Jeffrey L. Benovic

    11. Tracking Cell Surface Mobility of GPCRs Using a-Bungarotoxin Linked Fluorophores
    12. Saad Hannan, Megan E Wilkins, P Thomas and Trevor G Smart

    13. Regulatory Mechanism of G Protein-Coupled Receptor Trafficking to the Plasma Membrane: A Role for mRNA Localization
    14. Kusumam Joseph, Eleanor K. Spicer and Baby G. Tholanikunnel

    15. Dissecting Trafficking and Signaling of Atypical Chemokine Receptors
    16. Elena Borroni, Cinzia Cancellieri, Massimo Locati, Raffaella Bonecchi

      Trafficking Motifs

    17. Systematic and Quantitative Analysis of G Protein-Coupled Receptor Trafficking Motifs
    18. Carl M. Hurt, Vincent K. Ho, and Timothy Angelotti

    19. Identification of Endoplasmic Reticulum Export Motifs for G Protein-Coupled Receptors
    20. Guangyu Wu

    21. Amino Acid Residues of G-Protein Coupled Receptors Critical for Endoplasmic Reticulum Export and Trafficking
    22. Motonao Nakamura, Daisuke Yasuda, Nobuaki Hirota, Teruyasu Yamamoto, Satoshi Yamaguchi, Takao Shimizu and Teruyuki Nagamune

      GPCR Oligomerization

    23. G Protein-Coupled Heteromers Regulation in Disease
    24. Ivone Gomes, Achla Gupta and Lakshmi A. Devi

    25. Hetero-Oligomerization and Specificity Changes of G Protein-Coupled Purinergic Receptors: Novel Insight into Diversification of Signal Transduction
    26. Tokiko Suzuki, Kazunori Namba, Natsumi Mizuno and Hiroyasu Nakata

    27. Bimolecular Fluorescence Complementation Analysis of G Protein-Coupled Receptor Dimerization in Living Cells
    28. Karin F.K. Ejendal, Jason M. Conley, Chang-Deng Hu, and Val J. Watts

    29. G-Protein Coupled Receptor Heterodimerization in the Brain
    30. Dasiel O. Borroto-Escuela, Wilber Romero-Fernandez, Pere Garriga, Francisco Ciruela, Manuel Narvaez, Alexander O. Tarakanov, Miklós Palkovits, Luigi F. Agnati and Kjell Fuxe

    31. Experimental Strategies for Studying G Protein-Coupled Receptor Homo- and Heteromerization with Radioligand Binding and Signal Transduction Methods
    32. Roberto Maggio, Cristina Rocchi, and Marco Scarselli

    33. Analysis of GPCRs Dimerization Using Acceptor Photobleaching Resonance Energy Transfer Techniques
    34. Marta Busnelli, Mario Mauri, Marco Parenti and Bice Chini

    35. Techniques for the Discovery of GPCR-Associated Protein Complexes
    36. Avais Daulat , Pascal Maurice and Ralf Jockers

    37. Expression, Purification and Analysis of GProtein-Coupled Receptor Kinases
    38. Rachel Sterne-Marr, Alison I. Baillargeon, Kevin R. Michalski, and John J. G. Tesmer

    39. Modern Methods to Investigate the Oligomerization of Glycoprotein Hormone Receptors (TSHR,LHR, FSHR)

    Marco Bonomi and Luca Persani

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