Epigenetic Regulation in the Nervous System, 1st Edition,J. David Sweatt,Michael J. Meaney,Eric Nestler,Schahram Akbarian,ISBN9780123914941
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Epigenetic Regulation in the Nervous System, 1st Edition

Basic Mechanisms and Clinical Impact

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Editor(s) : Sweatt  &   Meaney  &   Nestler  &   Akbarian  

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Imprint: Academic Press

ISBN: 9780123914941

Pages: 376

Dimensions: 235 X 191

This book offers a comprehensive review of behavioral epigenetics and a balanced treatment of the strengths and weaknesses in experimentation in this area. A must-read for neuroscience researchers and graduate students with an interest in the links between gene regulation and behavior, as well as clinicians dealing with disorders such as addiction, depression, and schizophrenia.

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Key Features

  • Presents a unified view of epigenetic mechanisms from behavior to genes and everything in between
  • Discusses clinically relevant disorders in the context of epigenetics research, making the volume appealing to clinicians as well as basic scientists
  • Provides numerous practical examples for the new investigator to facilitate implementation of research in neuroepigenetics

Description

Epigenetic Regulation in the Nervous System addresses current understanding of the roles of epigenetic processes at the molecular/cellular level, their impact on neural development and behavior, and the potential roles of these mechanisms in neurological and psychiatric disorders. The book spans molecular epigenetics, development, cellular physiology and biochemistry, synaptic and neural plasticity, and behavioral models, and is unique in covering epigenetically based disorders of the central nervous system.

Behavioral epigenetics is the study of how environmental factors alter behavior, addressing the fundamental mechanisms that shape development and individual vulnerability/resilience to adverse behavioral outcomes. By understanding the molecular mechanisms involved in epigenetic modulation, researchers may be able to develop targeted therapies for those individuals in whom it malfunctions.

Edited by the most highly regarded leaders in the field, this volume offers a comprehensive review of behavioral epigenetics and a balanced treatment of the strengths and weaknesses in experimentation in this area. Covering background material as well as topics of current interest, it serves both as a cutting-edge resource and a foundational reference. The book will benefit neuroscience researchers and graduate students with an interest in the links between gene regulation and behavior, as will clinicians dealing with disorders such as addiction, depression, and schizophrenia.

J. David Sweatt

Affiliations and Expertise

University of Alabama, Birmingham, AL, USA

View additional works by J. David Sweatt

Michael J. Meaney

Affiliations and Expertise

Douglas Institute, McGill University, Montreal, Canada

Eric Nestler

Dr. Nestler is the Nash Family Professor of Neuroscience at the Mount Sinai School of Medicine in New York, where he serves as Chair of the Department of Neuroscience and Director of the Friedman Brain Institute. He received his B.A., Ph.D., and M.D. degrees, and psychiatry residency training, from Yale University. He served on the Yale faculty from 1987-2000, where he was the Elizabeth Mears and House Jameson Professor of Psychiatry and Neurobiology, and Director of the Division of Molecular Psychiatry. He moved to Dallas in 2000 where he served as the Lou and Ellen McGinley Distinguished Professor and Chair of the Department of Psychiatry at The University of Texas Southwestern Medical Center until moving to New York in 2008. Dr. Nestler is a member of the Institute of Medicine and a Fellow of the American Academy of Arts and Sciences. The goal of Dr. Nestler’s research is to better understand the molecular mechanisms of addiction and depression based on work in animal models, and to use this information to develop improved treatments of these disorders.

Affiliations and Expertise

Department of Neuroscience, Friedman Brain Institute, Mount Sinai School of Medicine, New York, New York, USA

Schahram Akbarian

Schahram Akbarian studied medicine and neuroanatomy at the Freie Universitaet Berlin, Germany. He is a board certified psychiatrist and molecular neuroscientist who trained at the Massachusetts General Hospital in Boston, the Whitehead Institute for Biomedical Research in Cambridge and the University of California at Irvine. Presently, he heads the Division of Psychiatric Epigenomics in the Departments of Psychiatry and Neuroscience at Mount Sinai School of Medicine. His work is focused on epigenetic mechanisms and the neurobiology of major psychiatric disorders, including depression, schizophrenia and related neurodevelopmental disease. This includes the exploration of the underlying molecular and cellular pathologies in the diseased brain, and the testing of novel treatments in preclinical (mouse) model systems.

Affiliations and Expertise

Department of Psychiatry, Friedman Brain Institute, Mount Sinai School of Medicine, New York, New York, USA

Epigenetic Regulation in the Nervous System, 1st Edition

1. An Overview of the Molecular Basis of Epigenetics
J. David Sweatt, Michael J. Meaney, Eric J. Nestler, and Schahram Akbarian

2. Histone modifications in the nervous system and neuropsychiatric disorders
Morgan Bridi and Edwin "Ted" Abel

3. Active DNA Demethylation and 5-Hydroxymethylcytosine
Junjie U. Guo, Guo-li Ming and Hongjun Song

4. Maternal Behavior
Tie Yuan Zhang, Christian Caldji, Josie C. Diorio, Sabine Dhir, Gustavo Turecki, and Michael J. Meaney

5. Epigenetic Mechanisms in Learning and Memory
Jeremy J. Day and J. David Sweatt

6. Drug Addiction and Reward
Alfred J. Robison, Jian Feng, and Eric J. Nestler

7. The Mind and its Nucleosomes - Chromatin (dys)regulation in Major Psychiatric Disease
Rahul Bharadwaj,  Cyril J. Peter, and Schahram Akbarian

8. HDAC inhibitors as novel therapeutics in Aging, and Alzheimer's disease
Alexi Nott, Daniel M. Fass, Stephen J. Haggarty, and Li-Huei Tsai

9. Cell Differentiation in the CNS, Neuronal Fate Determination, and Development
Yi Eve Sun

10. Imprinting in the CNS and Neurodevelopmental Disorders
Weston T. Powell and Janine LaSalle

11. Neuronal Genomic and Epigenetic Diversity
Michael J. McConnell and Fred H. Gage

12. Adult Neurogenesis
Jenny Hsieh, Hongjun Song

13. Transgenerational Inheritance in Mammals
Isabelle M. Mansuy, Rahia Mashoodh and Francis A. Champagne

14. Open Questions and Future Approaches in Neuroepigenetics
J. David Sweatt, Michael J. Meaney, Eric J. Nestler, and Schahram Akbarian

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Epigenetic Regulation in the Nervous System