Drug-Induced Liver Disease

Drug-Induced Liver Disease, 3rd Edition

Drug-Induced Liver Disease, 3rd Edition,Neil Kaplowitz,Laurie DeLeve,ISBN9780123878175

Kaplowitz   &   DeLeve   

Academic Press




281 X 222

The 3e contains comprehensive coverage of liver injury mechanisms, diagnosis and management, hepatotoxicity of specific drugs and regulatory and global perspectives.

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Key Features

  • A multi-authored reference work written by leading clinical, academic and industry experts in drug-induced liver disease.

  • Contains four new chapters on key areas in the field, including one on worldwide drug-induced liver injury networks.

  • Each chapter has been updated to address the latest research and findings in the field and 16 new chapter authors have been added to this new edition.

  • Includes coverage of the basic, clinical and practical aspects of drug-induced liver disease to provide the single most comprehensive reference on the subject. 


This field has shown tremendous growth in recent years, primarily due to the recognition that drug-induced liver disease is the most common cause of liver failure and one of the major contributors to the withdrawal of drugs developed by the pharmaceutical industry. Drug-Induced Liver Disease, 3rd edition is a comprehensive reference that covers mechanisms of injury, diagnosis and management, major hepatotoxins, regulatory perspectives and much more. Written by highly respected authorities, this new edition is an updated and definitive reference for clinicians and scientists in academia, the pharmaceutical industry and government settings. This book contains 4 new chapters on key topics in the area and provides a current and extensive review of the latest developments concerning the toxicology, pharmacology, genetics and immunology of drug-induced liver disease.


This reference is geared primarily towards medical specialists, including gastroenterologists, hepatologists, and pathologists, toxicologists, members of the pharmaceutical industry, and regulators.  This book also provides an extensive review of mechanisms of toxicity and of drug safety and would be an excellent reference for students of toxicology, as a secondary audience.

Neil Kaplowitz

Affiliations and Expertise

MD, Professor of Medicine, Chief, Division of Gastrointestinal and Liver Disease, University of Southern California, Keck School of Medicine

Laurie DeLeve

Affiliations and Expertise

MD, PhD, Professor of Medicine, Division of Gastrointestinal and Liver Diseases, University of Southern California Keck School of Medicine

Drug-Induced Liver Disease, 3rd Edition

Part I. Mechanisms of Liver Injury
Chapter 1: Drug-Induced Liver Injury: Introduction and Overview
Chapter 2: Cytochrome P450 Activation of Toxins and Hepatotoxicity
Chapter 3: Mechanistic Role of Acyl Glucuronides
Chapter 4: Oxidative Stress, Antioxidant Defense and Liver Injury
Chapter 5: Hepatotoxicity due to Mitochondrial Injury
Chapter 6: Mechanisms of Cell Death and Relevance to Drug Hepatotoxicity
Chapter 7: Role of Membrane Transport in Hepatotoxicity and Pathogenesis of Drug-Induced Cholestasis
Chapter 8: Liver Sinusoidal Endothelial Cell and Liver Injury
Chapter 9: Macrophages and Kupffer Cells in Hepatotoxicity
Chapter 10: Role of Inflammation in Drug-Induced Liver Disease
Chapter 11: Role of Adaptive Immune System
Chapter 12: Role of Tissue Repair in Liver Injury
Chapter 13: Genetic Factors in Pathogenesis

Part II. Diagnosis and Management
Chapter 14: Clinical Manifestations and Management of Drug-Induced Liver Diseases
Chapter 15: Histopathology of Drug-Induced Liver Disease
Chapter 16: Risk Factors for Drug-Induced Liver Disease
Chapter 17: The Promise of Genomics, Proteomics and Metabolomics of Blood and Liver in the Diagnosis of Drug-Induced Liver Disease
Chapter 18: Causality Assessment

Part III. Hepatotoxicity of Specific Drugs
Chapter 19: Mechanisms of Acetaminophen-Induced Liver Disease
Chapter 20: Acetaminophen - Pathology and Clinical Presentation of Hepatotoxicity
Chapter 21: Mechanisms Underlying the Hepatotoxicity of Non-Steroidal Anti-Inflammatory Drugs
Chapter 22: Non-Steroidal Anti-Inflammatory Drugs - Pathology and Clinical Presentation of Hepatotoxicity
Chapter 23: Mechanisms, Pathology and Clinical Presentation of Hepatotoxicity of Anesthetic Agents
Chapter 24: Anticonvulsant AgentsChapter 25: Psychotropic Drugs and Drugs of Abuse
Chapter 26: Hepatotoxicity of Antimicrobials and Antifungal Agents
Chapter 27: Antituberculosis Agents
Chapter 28: Hepatotoxicity in Antiviral Agents
Chapter 29: Hepatotoxicity of Cardiovascular and Antidiabetic Drugs
Chapter 30: Cancer Chemotherapy
Chapter 31: Hepatotoxicity of Immunomodulating Agents and the Transplant Situation
Chapter 32: Methotrexate
Chapter 33: Hormones and Hormone Antagonists
Chapter 34: Mushroom Poisoning: A Clinical Model of Toxin-Induced Centrilobular Necrosis
Chapter 35: Hepatotoxicity and Herbal Medicines, Vitamins and Natural Hepatoxins
Chapter 36: Occupational and Environmental Hepatotoxicity
Chapter 37: Chronic Liver Disease from Drugs

Part IV. Future Directions
Chapter 38: Regulatory Perspectives
Chapter 39: Drug-Induced Liver Injury Networks
Chapter 40: Liver Tox: The Future

Quotes and reviews

"This volume is a fascinating read for toxicologists interested in liver toxicity, since it provides an up-to-date view of the many mechanisms of hepatotoxicity… a must-have book which should be kept close at hand, in which case it will be opened regularly by toxicologists concerned with the development and safe use of medications in a practical context."--The British Toxicology Society Newsletter, 2008 (Review of 2nd edition)

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