Advances in Clinical Chemistry

Advances in Clinical Chemistry, 1st Edition

Advances in Clinical Chemistry, 1st Edition,Gregory Makowski,ISBN9780123870421

Advances in Clinical Chemistry

G Makowski   

Academic Press




229 X 152

An indispensable resource and practical guide for 21st century practitioners of the clinical laboratory sciences

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Key Features

  • Leading experts from academia and clinical laboratory science
  • Volume emphasizes novel laboratory advances with application to clinical laboratory diagnostics and practical basic science studies


Volume 55 in the internationally acclaimed Advances in Clinical Chemistry contains chapters submitted from leading experts from academia and clinical laboratory science. Authors are from a diverse field of clinical chemistry disciplines and diagnostics, ranging from basic biochemical exploration to cutting-edge microarray technology.


Biochemists and clinical biochemists

Gregory Makowski

Dr Gregory S Makowski is a board certified clinical chemist and fellow of the National Academy of Clinical Biochemistry. Following receipt of his PhD in Biochemistry from the University of Connecticut Storrs, he pursued post-doctoral studies at the University of Connecticut School of Medicine in Farmington that culminated in his joint appointments in the School of Medicine and the Department of Laboratory Medicine at John Dempsey Hospital. He has numerous clinical and basic science publications and serves on various scientific and editorial boards. He is actively engaged in the training of Pathology residents and fellows in the Department of Pathology and Laboratory Medicine at Hartford Hospital. He currently serves as Vice President and Chief Scientific Officer for Clinical Laboratory Partners in Newington CT, USA.

Affiliations and Expertise

Clinical Laboratory Partners, Newington; Hartford Hospital, Hartford; Department of Laboratory Medicine, University of Connecticut Health Center, Farmington, CT, USA

View additional works by Gregory S. Makowski

Advances in Clinical Chemistry, 1st Edition

  • Contributors
  • Preface
  • HE4 in ovarian cancer
    • 1. Abstract
    • 2. Introduction
    • 3. CA125
    • 4. Biomarker Identification: From Genomics to Proteomics
    • 5. Clinical Validation of a Tumor Biomarker
    • 6. HE4: Discovery to Clinical Application
    • 7. Conclusions
  • Salivary Transcriptome Biomarkers in Oral Squamous Cell Cancer Detection
    • 1. Abstract
    • 2. Introduction
    • 3. The Salivary Transcriptome: Characterization and Biomarker Discovery
    • 4. Etiopathology of OSCC: The Field Cancerization Theory
    • 5. Molecular Alterations in OSCC
    • 6. Biomarkers: Adequate Study Design (PRoBE Design)
    • 7. Outlook, Conclusion, and the Oral Fluid Nanosensor Test
  • Laminin isoform profiles in salivary glands in Sjögren's syndrome
    • Abbreviations
    • 1. Abstract
    • 2. Sjögren's Syndrome
    • 3. Structure of the Human Labial Salivary Glands
    • 4. Basement Membrane
    • 5. Laminins
    • 6. LM Receptors
    • 7. Regulation of LMs in Salivary Glands
    • 8. Conclusion
    • Acknowledgments
  • Adipokine actions on cartilage homeostasis
    • Abbreviations
    • 1. Abstract
    • 2. Introduction
    • 3. Relevance of Adipokines in Cartilage Disease
    • 4. Measurement of Adipokines
    • 5. Adipokines and Cartilage Homeostasis: Integrated View and Perspectives
  • Chemical Biology of Homocysteine Thiolactone and Related Metabolites
    • Abbreviations
    • 1. Abstract
    • 2. Introduction
    • 3. Homocysteine Thiolactone
    • 4. N-Homocysteinylated Proteins
    • 5. Ne-Homocysteinyl-lysine
    • 6. Conclusions
  • Iron overload in nonalcoholic steatohepatitis
    • Abbreviations
    • 1. Abstract
    • 2. Introduction
    • 3. Incidence of Iron Overload in NAFLD/NASH
    • 4. Search for the Mechanism of Iron Overload in NAFLD/NASH
    • 5. Clinical Impact of Iron Overload in NAFLD/NASH
    • 6. Conclusion
  • Triglyceride metabolism in pregnancy
    • 1. Abstract
    • 2. Introduction
    • 3. Maternal Lipid Metabolism During Pregnancy
    • 4. Lipid Metabolism and Maternal Pregnancy Complications
    • 5. Maternal Hypertriglyceridemia and Fetal Complications
    • 6. Changes in Lipids During Pregnancy and Risk of Cardiovascular Disease
    • 7. Hypertriglyceridemia During Pregnancy: Treatment
    • 8. Conclusions
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