Advances in Clinical Chemistry

Advances in Clinical Chemistry, 1st Edition

Advances in Clinical Chemistry, 1st Edition,Gregory Makowski,ISBN9780123870254

Advances in Clinical Chemistry

G Makowski   

Academic Press




229 X 152

An indispensable resource and practical guide for 21st century practitioners of the clinical laboratory sciences

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Key Features

  • Leading experts from academia and clinical laboratory science
  • Volume emphasizes novel laboratory advances with application to clinical laboratory diagnostics and practical basic science studies


Volume 54 in the internationally acclaimed Advances in Clinical Chemistry contains chapters submitted from leading experts from academia and clinical laboratory science. Authors are from a diverse field of clinical chemistry disciplines and diagnostics, ranging from basic biochemical exploration to cutting-edge microarray technology.


Biochemists and clinical biochemists

Gregory Makowski

Dr Gregory S Makowski is a board certified clinical chemist and fellow of the National Academy of Clinical Biochemistry. Following receipt of his PhD in Biochemistry from the University of Connecticut Storrs, he pursued post-doctoral studies at the University of Connecticut School of Medicine in Farmington that culminated in his joint appointments in the School of Medicine and the Department of Laboratory Medicine at John Dempsey Hospital. He has numerous clinical and basic science publications and serves on various scientific and editorial boards. He is actively engaged in the training of Pathology residents and fellows in the Department of Pathology and Laboratory Medicine at Hartford Hospital. He currently serves as Vice President and Chief Scientific Officer for Clinical Laboratory Partners in Newington CT, USA.

Affiliations and Expertise

Clinical Laboratory Partners, Newington; Hartford Hospital, Hartford; Department of Laboratory Medicine, University of Connecticut Health Center, Farmington, CT, USA

View additional works by Gregory S. Makowski

Advances in Clinical Chemistry, 1st Edition

  • Preface
  • Heat-shock proteins in cardiovascular disease
    • Abbreviations
    • 2. Introduction
    • 3. Atherogenesis and Possible Stimuli of Inducible HSPs
    • 4. HSPs/Anti-HSPs as Biomarkers of Atherothrombosis
    • 5. Molecular Mechanisms: Bystanders or Actors?
    • 6. HSP as Therapeutic Targets in CVD/Atherothrombosis
    • 7. Conclusions
    • Acknowledgments
  • Polyamines in cancer
    • Abbreviations
    • 2. Introduction
    • 3. Overview of Polyamine Regulation
    • 4. Deregulation of Polyamines in Cancer
    • 5. Genetic Variability in ODC Affecting Carcinogenesis
    • 6. EIF5A and Cancer
    • 7. Chemoprevention Strategies Within Polyamine Pathway
    • Acknowledgments
  • Acquired hemophilia A
    • 2. Introduction
    • 3. Pathogenesis
    • 4. Laboratory Diagnosis
    • 5. Conclusions
    • Acknowledgments
  • Hypobetalipoproteinemia
    • Abbreviations
    • 2. Introduction
    • 3. Pathways of apoB-Containing Lipoproteins Production
    • 4. Dominant Forms of Primary HBL
    • 5. Recessive Forms of Primary HBL
    • 6. Primary Orphan FHBL
    • 7. Spectrum of Clinical Manifestations in Primary HBL
    • 8. Main Clinical Issues of FHBL
    • 9. Secondary Hypobetalipoproteinemias
    • 10. Conclusions
    • Addendum
    • Acknowledgment
  • Sm peptides in differentiation of autoimmune diseases
    • 2. Introduction
    • 3. Systemic Lupus Erythematosus
    • 4. Mixed Connective Tissue Disease
    • 5. Biochemical Aspects of the Sm Antigen
    • 6. Characteristics of Anti-Sm Antibodies
    • 7. Detection of Anti-Sm Antibodies
    • 8. Clinical Association of Anti-Sm Antibodies
    • 9. Meta-Analysis of Anti-Sm Antibodies
    • 10. Genesis of Anti-Sm Antibodies
    • 11. (Sm) Peptides as Antigens
    • 12. Summary and Conclusion
    • 13. Take Home Messages
  • Aromatase activity and bone loss
    • 2. Introduction
    • 3. Aromatase and Sources of Estrogen Production
    • 4. The Aromatase Gene and Its Tissue-Specific Regulation
    • 5. Aromatase Deficiency and the Bone
    • 6. Skeletal Consequences of Aromatase Excess
    • 7. Threshold Estradiol Hypothesis for Skeletal Sufficiency
    • 8. Variability in the Level of Aromatase Activity: Effects on Bone Metabolism
    • 9. Summary and Conclusions
  • Biochemistry of adolescent idiopathic scoliosis
    • 2. Introduction
    • 3. Bone Biochemical Parameters
    • 4. Hormones
    • 5. Trace Elements
    • 6. Hematological Parameters—Platelets
    • 7. Melatonin
    • 8. Conclusions
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