Primer on the Autonomic Nervous System

Primer on the Autonomic Nervous System, 3rd Edition

Primer on the Autonomic Nervous System, 3rd Edition,David Robertson,Phillip Low,Ronald Polinsky,ISBN9780123865250

Robertson   &   Low   &   Polinsky   

Academic Press




276 X 216

An up-to-date review of the basic and clinical autonomic neuroscience knowledge intended for students, researchers and physicians

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Key Features

  • Greatly amplified and updated from previous edition including the latest developments in the field of autonomic cardiovascular regulation and neuroscience
  • Provides key information about all aspects of autonomic physiology and pathology
  • Discusses stress and how its effects on the body are mediated
  • Compiles contributions by over 140 experts on the autonomic nervous system


The Primer on the Autonomic Nervous System presents, in a readable and accessible format, key information about how the autonomic nervous system controls the body, particularly in response to stress. It represents the largest collection of world-wide autonomic nervous system authorities ever assembled in one book. It is especially suitable for students, scientists and physicians seeking key information about all aspects of autonomic physiology and pathology in one convenient source. Providing up-to-date knowledge about basic and clinical autonomic neuroscience in a format designed to make learning easy and fun, this book is a must-have for any neuroscientist’s bookshelf!


Researchers, clinical practitioners, medical and graduate students in neuroscience and neurology

David Robertson

Affiliations and Expertise

Clinical Research Center, Vanderbilt University, Nashville, Tennessee, U.S.A.

View additional works by David Robertson

Phillip Low

Affiliations and Expertise

The Mayo Clinic, Rochester, Minnesota, U.S.A.

Ronald Polinsky

Affiliations and Expertise

Sandoz Research Institute, East Hanover, New Jersey, U.S.A.

Primer on the Autonomic Nervous System, 3rd Edition


List of Contributors

Chapter 1. Development and Differentiation of Autonomic Neurons

Chapter 2. Central Autonomic Control

Chapter 3. Imaging of Brainstem Sites Involved in Cardiovascular Control

Chapter 4. Peripheral Autonomic Nervous System

Chapter 5. Cotransmission

Chapter 6. Noradrenergic Neurotransmission

Chapter 7. Tyrosine Hydroxylase

Chapter 8. Antidepressant-Sensitive Norepinephrine Transporters

Chapter 9. a1-Adrenergic Receptors

Chapter 10. a2-Adrenergic Receptors

Chapter 11. ß-Adrenergic Receptors

Chapter 12. Dopaminergic Neurotransmission

Chapter 13. Dopamine Receptors

Chapter 14. Cholinergic Neurotransmission

Chapter 15. Acetylcholine and Muscarinic Receptors

Chapter 16. Nicotinic Receptors

Chapter 17. Serotonin Receptors and Neurotransmission

Chapter 18. Purinergic Neurotransmission and Nucleotide Receptors

Chapter 19. Adenosine Receptors and Autonomic Regulation

Chapter 20. Nitric Oxide and Autonomic Regulation

Chapter 21. Glutamatergic Neurotransmission

Chapter 22. GABAergic Neurotransmission

Chapter 23. Renin-Angiotensin

Chapter 24. Aldosterone and the Mineralocorticoid Receptor

Chapter 25. Vasopressin and Disorders of Water Homeostasis

Chapter 26. Calcitonin Gene-Related Peptide and Adrenomedullin

Chapter 27. Leptin Signaling and Energy Homeostasis

Chapter 28. The Endothelin System

Chapter 29. Pharmacology of the Nucleous Tractus Solitarii

Chapter 30. Entrainment of Sympathetic Rhythms

Chapter 31. Cross-talk Between Body Systems

Chapter 32. Circadian Rhythms and Autonomic Function

Chapter 33. Baroreceptor Reflexes

Chapter 34. Genetic Determinants of Baroreflex Function

Chapter 35. Cardiac and Other Visceral Afferents

Chapter 36. Autonomic Control of the Heart

Chapter 37. Cardiac Vagal Ganglia

Chapter 38. Neural Control of Blood Vessels

Chapter 39. Physiology of Upright Posture

Chapter 40. Cerebral Circulation

Chapter 41. Autonomic Control of the Lower Airways

Chapter 42. Gastrointestinal Function

Chapter 43. The Splanchnic Circulation

Chapter 44. Autonomic Control of the Kidney

Chapter 45. Dopamine Mechanisms in the Kidney

Chapter 46. Autonomic Control of the Lower Urinary Tract

Chapter 47. Bladder Function in Health and Disease

Chapter 48. Physiology and Pathophysiology of Female Sexual Function

Chapter 49. Control of the Pupil

Chapter 50. Central Thermoregulation

Chapter 51. Sweating

Chapter 52. Regulation of Metabolism

Chapter 53. Autonomic Innervation of the Skeleton

Chapter 54. Sex Differences in Autonomic Function

Chapter 55. Autonomic Control During Pregnancy

Chapter 56. Aging and the Autonomic Nervous System

Chapter 57. Exercise

Chapter 58. Effects of High Altitude

Chapter 59. Space Physiology

Chapter 60. Hypothermia and Hyperthermia

Chapter 61. Psychological Stress and the Autonomic Nervous System

Chapter 62. Mind–Body Interactions

Chapter 63. Alpha-Synuclein and Neurodegeneration

Chapter 64. Insulin Resistance and the Autonomic Nervous System

Chapter 65. Salt Sensitivity of Blood Pressure

Chapter 66. Endothelial Dysfunction

Chapter 67. Inflammation, Immunity and the Autonomic Nervous System

Chapter 68. Oxygen Sensing

Chapter 69. Reactive Oxygen Species and Oxidative Stress

Chapter 70. Neurally Mediated Syncope

Chapter 71. Sympatho-Vagal Imbalance in Hypertension

Chapter 72. Baroreflex Failure

Chapter 73. Blood Pressure Variability

Chapter 74. Obesity-Associated Hypertension

Chapter 75. Orthostatic Hypertension

Chapter 76. Heart Failure

Chapter 77. Stress Cardiomyopathy and Takotsubo Syndrome

Chapter 78. Clinical Evaluation of Autonomic Disorders

Chapter 79. Tilt Table Studies

10. Questions About Head-Up Tilt Table Testing

Chapter 80. Sympathetic Microneurography

Chapter 81. Clinical Applications of Microneurography

Chapter 82. Clinical Sympathetic Imaging

Chapter 83. Assessment of the Autonomic Control of the Cardiovascular System by a Frequency Domain Approach

Chapter 84. Assessment of Sudomotor Function

Chapter 85. Cutaneous Autonomic Innervation

Chapter 86. Pheochromocytoma

Chapter 87. Deficiencies of Tetrahydrobiopterin, Tyrosine Hydroxylase and Aromatic L-Amino Acid Decarboxylase

Chapter 88. Dopamine ß-Hydroxylase Deficiency

Chapter 89. Menkes Disease and Other ATP7A-Related Phenotypes

Chapter 90. Norepinephrine Transporter Deficiency

Chapter 91. Monoamine Oxidase Deficiency

Chapter 92. Congenital Central Hypoventilation Syndrome (CCHS) and PHOX2B Mutations

Chapter 93. Multiple System Atrophy

Chapter 94. Parkinson’s Disease

Chapter 95. Dementia with Lewy Bodies

Chapter 96. Pure Autonomic Failure

Chapter 97. Diagnostic Workup of Peripheral Neuropathies with Dysautonomia

Chapter 98. Diabetic Autonomic Dysfunction

Chapter 99. Amyloidotic Autonomic Failure

Chapter 100. Autoimmune Autonomic Ganglionopathy

Chapter 101. Guillain–Barré Syndrome

Chapter 102. Hereditary Autonomic Neuropathies

Chapter 103. Familial Dysautonomia (Riley–Day Syndrome)

Chapter 104. Autonomic Disturbances in Spinal Cord Injuries

Chapter 105. Drug-Induced Autonomic Dysfunction

Chapter 106. Postural Tachycardia Syndrome (POTS)

Chapter 107. Mechanisms of Postural Tachycardia Syndrome

Chapter 108. Symptoms and Signs of Postural Tachycardia Syndrome (POTS)

Chapter 109. Delayed Orthostatic Hypotension

Chapter 110. Chronic Fatigue Syndrome and the Autonomic Nervous System

Chapter 111. Joint Hypermobility Syndrome and Dysautonomia

Chapter 112. Neuroleptic Malignant Syndrome

Chapter 113. Migraine and the Autonomic Nervous System*

Chapter 114. Epilepsy and Autonomic Regulation

Chapter 115. Disorders of Sweating

Chapter 116. Male Erectile Dysfunction

Chapter 117. Sleep Apnea

Chapter 118. Altered Adrenal Function and the Autonomic Nervous System

Chapter 119. Mastocytosis

Chapter 120. Cocaine Overdose

Chapter 121. Complex Regional Pain Syndrome

Chapter 122. Carcinoid Tumors

Chapter 123. Paraneoplastic Autonomic Dysfunction

Chapter 124. Abdominal Pain and Cyclic Vomiting

Chapter 125. Fecal Incontinence

Chapter 126. Panic Disorder

Chapter 127. Physical Measures

Chapter 128. Water and the Osmopressor Response

Chapter 129. Droxidopa (L-DOPS)

Chapter 130. Midodrine, Adrenergic Agonists and Antagonists

Chapter 131. Agents Potentiating Sympathetic Tone

Chapter 132. Acetylcholinesterase and its Inhibitors

Chapter 133. Fludrocortisone

Chapter 134. Acarbose

Chapter 135. Erythropoietin in Autonomic Failure

Chapter 136. Somatostatin Agonists

Chapter 137. Harnessing the Autonomic Nervous System for Therapeutic Intervention

Chapter 138. Acupuncture Regulation of Cardiovascular Function

Chapter 139. Bionic Baroreflex

Chapter 140. Anesthetic Management in Autonomic Disorders

Chapter 141. Evolution of the Cardiovascular Autonomic Nervous System in Vertebrates

Chapter 142. Human Physiome

Chapter 143. Modeling the Autonomic Nervous System

Chapter 144. Optogenetics


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