Advances in Immunology

Advances in Immunology, 1st Edition

Advances in Immunology, 1st Edition,Frederick Alt,ISBN9780123859914

Advances in Immunology

F Alt   

Academic Press




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Cutting-edge reviews in immunology

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Key Features

  • Contributions from leading authorities and industry experts
  • Informs and updates on all the latest developments in the field


Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.


Immunologists and infectious disease specialists, cell biologists and hematologists

Frederick Alt

Affiliations and Expertise

Howard Hughes Medical Institute Research Laboratories, The Children's Hospital, Boston, MA, USA

View additional works by Frederick W. Alt

Advances in Immunology, 1st Edition


Early Steps of Follicular Lymphoma Pathogenesis

1. Follicular Lymphoma

2. The Classical Model of Follicular Lymphomagenesis

3. Circulating and Resident t(14;18) Cells Detected in Healthy Individuals are not Naive B-Cells

4. The “Allelic Paradox”: A Particular Immuno/Genophenotype of t(14;18)+ Activated B-Cells Which Does Not Match Any of the Physiological Memory Subsets Present in Blood

5. A Fraction of t(14;18) Cells in Healthy Carriers are Developmentally “Blocked” Follicular Lymphoma-Like Cells (FLLC)

6. BCL2, BCL6, Maturation Arrest, and the Role of the IgM Receptor

7. Trafficking, Early Dissemination, and Progression

8. A Protracted Model of Multi-Hit FL Genesis

9. Perspectives


“A Rose is a Rose is a Rose,” but CVID is Not CVID

1. Introduction

2. Definition and Diagnostic Criteria

3. Epidemiology

4. Pathophysiology/Immunopathology

5. Etiology/Genetics

6. CVID Classification Schemes

7. Clinical Presentation and Complications

8. Management

9. Prognosis and Survival

10. Summary

Role of Activation-Induced Cytidine Deaminase in Inflammation-Associated Cancer Development


1. Introduction: Cancer as a Genetic Disease

2. Nucleotide-Editing Enzymes as Inducers of Mutations

3. Physiologic Roles of AID in Antibody Production

4. Regulation of AID Expression in B Cells

5. Excessive AID Activity and Genetic Alterations Leading to Tumorigenesis

6. Roles of AID in Inflammation-Associated Human Carcinogenesis

7. Role of AID in the Development of Hematopoietic Malignancy

8. Conclusion


Comparative Genomics and Evolution of Immunoglobulin-Encoding Loci in Tetrapods

1. Introduction

2. Structure and Function of Antibodies

3. Ig-Heavy Chain in Tetrapods

4. Ig-Light Chains in Tetrapods

5. Evolution of Immunoglobulin J-Chain

6. Noncanonical Antibodies in Camelids

7. Concordance and Divergence of the Generation of Antibody Diversity

8. Concluding Remarks



1. Pax5 and B Cell Commitment

2. Pax5 and the Control of Igh Rearrangements

3. Pax5 and Late B Cell Development

4. Role of Pax5 in B Cell Malignancies

5. Perspective


Quotes and reviews

"The series which all immunologists need." --The Pharmaceutical Journal

"Advances in Immunology must find itself among the most active volumes in the libraries of our universities and institutions." --Science

"Deserves a permanent place in biomedical libraries as an aid in research and in teaching." --Journal of Immunological Methods

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