Chagas Disease, 1st Edition

Part B

Chagas Disease, 1st Edition,Louis M. Weiss,Herbert B. Tanowitz,ISBN9780123858955

Advances in Parasitology

Weiss   &   Tanowitz   

Academic Press




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Cutting-edge reviews in parasitology

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Key Features

  • Informs and updates on all the latest developments in the field
  • Contributions from leading authorities and industry experts


This thematic volume provides authoritative, up-to-date reviews addressing recent advances as well as an overview for the research and clinical communities on the endemic infection of Chagas disease. Lead researchers discuss epidemiology and control measures as well as various diagnosis techniques, treatments, and therapies currently being used. The text includes a history of Chagas disease and an outlook for the next century.


Researchers in parasitology, tropical medicine and entomology.

Louis M. Weiss

Louis M. Weiss M.D., M.P.H is Professor of Medicine (Division of Infectious Diseases) and Professor of Pathology (Division of Parasitology and Tropical Medicine) of the Albert Einstein College of Medicine, Bronx, New York. Dr. Weiss received his M.D. and M.P.H degrees from the Johns Hopkins University in 1982. He then completed a residency in Internal Medicine at the University of Chicago and a fellowship in Infectious Diseases at the Albert Einstein College of Medicine. Following this fellowship, he joined the faculty at Einstein where he is currently a Professor of Pathology and Medicine. His laboratory group has an active research program on parasitic diseases with a research focus on Toxoplasma gondii, the Microsporidia and Trypanosoma cruzi. Dr. Weiss is the author of over 200 publications and the editor of 3 books on parasitology. He is a fellow of the American College of Physicians, Infectious Disease Society of America and the American Academy of Microbiology. Dr. Weiss is the Co-Director of the Einstein Global Health Center.

Affiliations and Expertise

Professor of Medicine and Pathology, Albert Einstein College of Medicine of Yeshiva University, New York, U.S.A.

View additional works by Louis M. Weiss
Information about this author is currently not available.

Chagas Disease, 1st Edition

Contributors of Volume 76


Bioactive Lipids in Trypanosoma cruzi Infection


1.1. Introduction

1.2. Eicosanoid Synthesis in Vertebrates

1.3. Lipid Metabolism and Eicosanoid Biosynthetic Pathways in Trypanosoma cruzi

1.4. Endogenous Regulation of Eicosanoids During Experimental Chagas Disease

1.5. Lessons from Pharmacological Manipulation and from Null Mice


Mechanisms of Host Cell Invasion by Trypanosoma cruzi

2.1. Introduction

2.2. General Features of Trypanosoma cruzi Invasion

2.3. To the Lysosome … and Beyond

2.4. Disruption of the Parasitophorous Vacuole Membrane and Cytosolic Localization of Parasites

2.5. The Role of the Host Cell Cytoskeleton in Trypanosoma cruzi Trypomastigote Invasion of Non-Phagocytic Cells

2.6. The Discovery of Reversible Invasion

2.7. Concluding Remarks

Gap Junctions and Chagas Disease

3.1. Introduction

3.2. Loss of Gap Junctions and Coupling in Rodent Chagasic Cardiomyopathy

3.3. Not All Junctional Proteins are Affected by Trypanosoma cruzi Infection

3.4. Microarray Experiments have Revealed Profound Changes in Gene Expression in the Chagasic Mouse, Both in Acute and in Chronic Disease Phases

3.5. Conclusions

The Vasculature in Chagas Disease

4.1. Historical Aspects

4.2. Small Animal Studies of the Microcirculation in Trypanosoma cruzi Infection

4.3. Studies in Dogs

4.4. Vasoactive Peptides and Eicosanoids

4.5. In Vitro Studies

4.6. Studies in Humans

4.7. Conclusions


Infection-Associated Vasculopathy in Experimental Chagas Disease


5.1. Introduction

5.2. A Brief Overview on the Immunopathogenesis of Chagas Disease

5.3. Future Directions



6.1. Introduction

6.2. Natural History of Chagas Disease

6.3. Heart-Specific Inflammatory Lesions in CCC: Parasite Antigen-Driven Immunopathology?

6.4. Immunopathogenesis of CCC

6.5. Autoimmunity in Chagas Disease

6.6. Molecular Mimicry

6.7. Conclusion

ROS Signalling of Inflammatory Cytokines During Trypanosoma cruzi Infection

7.1. Reactive Oxygen Species and Source

7.2. Inflammatory Cytokines During Trypanosoma cruzi Infection and Chagas Disease

7.3. ROS Signalling of Cytokine Responses

7.4. The Impact of Oxidative Stress and Cytokine Mediators and Cardiac Dysfunction

7.5. Conclusions and Future Directions


Inflammation and Chagas Disease

8.1. The Multiple Roles of Inflammation in Chagas Disease

8.2. Experimental Models for Studying Inflammation and Immune Mechanisms in Chagas Disease

8.3. Mediators of Protection in Experimental Trypanosoma cruzi Infection

8.4. Mediators of Inflammation and Their Role in Mediating Tissue Damage and Protection in Experimental Trypanosoma cruzi Infection

8.5. Conclusion


Neurodegeneration and Neuroregeneration in Chagas Disease

9.1. Introduction

9.2. Involvement of the Autonomic Nervous System in CD Pathogenesis

9.3. Mechanism of Neuronal Damage

9.4. Neuroregeneration

9.5. Trans-Sialidase/Parasite-Derived Neurotrophic Factor

9.6. Conclusions

Adipose Tissue, Diabetes and Chagas Disease

10.1. Introduction

10.2. Adiponectin

10.3. Adipose Tissue and Infection

10.4. Chagas Disease and Adipose Tissue

10.5. Chagas Disease and Glycaemia

10.6. Conclusions


Quotes and reviews

"One is struck by the quality and scholarship of the various chapters and the obviously efficient editing."--PARASITOLOGY
"The policy of the editors of
Advances in Parasitology to include reviews from any aspect of parasitology and the high standard of individual papers have resulted in this series of volumes becoming an indispensable source for students, teachers, and research workers."--ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY
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