Fundamental Neuroscience

Fundamental Neuroscience, 4th Edition

Fundamental Neuroscience, 4th Edition,Larry Squire,Darwin Berg,Floyd E. Bloom,Sascha du Lac,Anirvan Ghosh,Nicholas C. Spitzer,ISBN9780123858702

Squire   &   Berg   &   Bloom   &   du Lac   &   Ghosh   &   Spitzer   

Academic Press




281 X 222

The ideal textbook for graduate and advanced undergraduate students in neuroscience and neurobiology, edited and authored by the foremost leaders in the field, with comprehensive coverage of systems neuroscience.

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Key Features

  • Selected for inclusion in Doody's Core Titles 2013, an essential collection development tool for health sciences libraries
  • 30% new material including new chapters on dendritic development and spine morphogenesis, chemical senses, cerebellum, eye movements, circadian timing, sleep and dreaming, and consciousness
  • Accompanying website for students and instructors
  • Additional text boxes describing key experiments, disorders, methods, and concepts
  • More than 650 four-color illustrations, micrographs, and neuroimages
  • Multiple model system coverage beyond rats, mice, and monkeys
  • Extensively expanded index for easier referencing


The fourth edition of Fundamental Neuroscience reinvents itself as an engrossing and comprehensive presentation of the discipline of neuroscience, from molecules to cognition. Thorough but succinct, and lavishly illustrated, the book builds from an introductory section that includes fundamental neuroanatomy and goes on to cover cellular and molecular neuroscience, development, sensory systems, motor systems, regulatory systems, and behavioral and cognitive neuroscience. The book has been retooled to better serve its audience in the neuroscience and medical communities.

The chapters include more than 100 boxes describing clinical conditions, techniques, and other special topics. Each chapter went through a thorough review process, giving the book an evenness of tone. The chapters are authored by outstanding working scientists who are experts on the topics they cover.


Graduate students in neuroscience, neuroanatomy and neurophysiology, and neurobiology. The secondary market for this book is researchers in neuroscience primarily, but also in the related fields of psychology, cell biology, molecular biology, genetics and any other areas of science with cross over into neuroscience research.

Larry Squire

Affiliations and Expertise

University of California, San Diego, La Jolla, CA, USA

Darwin Berg

Affiliations and Expertise

University of California, San Diego, La Jolla, CA, USA

Floyd E. Bloom

Affiliations and Expertise

Scripps Research Institute, La Jolla, CA, USA

View additional works by Floyd E. Bloom

Sascha du Lac

Affiliations and Expertise

The Salk Institute, La Jolla, CA, USA

Anirvan Ghosh

Affiliations and Expertise

University of California, San Diego, La Jolla, CA, USA

Nicholas C. Spitzer

Affiliations and Expertise

University of California, San Diego, La Jolla, CA, USA

Fundamental Neuroscience, 4th Edition

List of Boxes
Preface to the Fourth Edition
About the Editors

1. Fundamentals of Neuroscience
Floyd E. Bloom
2. Basic Plan of the Nervous System
Larry W. Swanson

3. Cellular Components of Nervous Tissue
Patrick R. Hof, Grahame Kidd, Javier DeFelipe, Jean de Vellis, Miguel A. Gama Sosa, Gregory A. Elder, and Bruce D. Trapp
4. Subcellular Organization of the Nervous System: Organelles and Their Functions
Scott T. Brady, David R. Colman, and Peter J. Brophy
5. Membrane Potential and Action Potential
David A. McCormick
6. Neurotransmitters
Ariel Y. Deutch
7. Release of Neurotransmitters
Thomas L. Schwarz
8. Neurotransmitter Receptors
M. Neal Waxham
9. Intracellular Signaling
Howard Schulman
10. Postsynaptic Potentials and Synaptic Integration
John H. Byrne
11. Information Processing in Dendrites and Spines
Nelson Spruston, Michael Hausser, and Greg Stuart
12. Brain Energy Metabolism
Igor Allaman and Pierre J. Magistretti

13. Neural Induction and Pattern Formation
Andrew Lumsden and Clemens Kiecker
14. Cellular Determination
William A. Harris, Volker Hartenstein, and Martyn Goulding
15. Neurogenesis and Migration
Marianne Bronner and Mary E. Hatten
16. Growth Cones and Axon Pathfinding
Alex L. Kolodkin and Marc Tessier-Lavigne
17. Synapse Formation
Steven J. Burden and Peter Scheiffele
18. Programmed Cell Death and Neurotrophic Factors
Ronald W. Oppenheim, Carolanne E. Milligan, and Christopher S. von Bartheld
19. Synapse Elimination
Juan C. Tapia and Jeff W. Lichtman
20. Dendritic Development
Hollis Cline, Anirvan Ghosh, Yuh-Nung Jan, and Josh Sanes
21. Early Experience and Sensitive Periods
Eric I. Knudsen

22. Fundamentals of Sensory Systems
Stewart H. Hendry and Steven S. Hsiao
23. Chemical Senses: Taste and Olfaction
Kristin Scott
24. The Somatosensory System
Stewart Hendry and Steven Hsiao
25. Audition
M. Christian Brown and Joseph Santos-Sacchi
26. Vision
R. Clay Reid and W. Martin Usrey

27. Fundamentals of Motor Systems
Sten Grillner
28. The Spinal and Peripheral Motor System
George Z. Mentis
29. Control of Movement
Marc H. Schieber and James F. Baker
30. The Basal Ganglia
Jonathan W. Mink
31. Cerebellum
Martha Bagnall, Sascha du Lac, and Michael Mauk
32. Eye Movements
Richard J. Krauzlis

33. The Hypothalamus: An Overview of Regulatory Systems
J. Patrick Card and Larry W. Swanson
34. Central Control of Autonomic Functions: Organization of the Autonomic Nervous System
Terry L. Powley
35. Neural Control of Respiratory and Cardiovascular Functions
J.L. Feldman, D.R. McCrimmon, and S.F. Morrison
36. Food Intake and Metabolism
Stephen C. Woods and Edward M. Stricker
37. Water and Salt Intake and Body Fluid Homeostasis
Edward M. Stricker and Joseph G. Verbalis
38. Neuroendocrine Systems
Andrea C. Gore
39. Circadian Timekeeping
David R. Weaver and Patrick Emery
40. The Neurobiology of Sleep and Dreaming
Edward F. Pace-Schott and J. Allan Hobson
41. Reward, Motivation, and Addiction
George F. Koob, Barry J. Everitt, and Trevor W. Robbins

42. Human Brain Evolution
Jon H. Kaas and Todd M. Preuss
43. Cognitive Development and Aging
Peter R. Rapp and Jocelyne Bachevalier
44. Visual Perception of Objects
Andrew H. Bell, Luiz Pessoa, Roger B.H. Tootell, and Leslie G. Ungerleider
45. Spatial Cognition
Carl R. Olson and Carol L. Colby
46. Attention
John H. Reynolds, Jacqueline P. Gottlieb, and Sabine Kastner
47. Learning and Memory: Basic Mechanisms
John H. Byrne
48. Learning and Memory: Brain Systems
Joseph R. Manns and Elizabeth A. Buffalo
49. Language
David N. Caplan and James L. Gould
50. The Prefrontal Cortex and Executive Brain Functions
Earl K. Miller and Jonathan D. Wallis
51. The Neuroscience of Consciousness
Christof Koch


Quotes and reviews

"Here in the fourth edition of this textbook, editors Squire, Berg, Bloom, du Lac, Ghosh, and Spitzer, all working scientists with backgrounds in various specialties in neuroscience, present extensive new material with all chapters updated and rewritten. The book is organized into seven sections with numerous chapters in each encompassing a comprehensive view of 21st century neuroscience…"--Reference & Research Book News, December 2013

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