Principles of Clinical Pharmacology

Principles of Clinical Pharmacology, 3rd Edition

Principles of Clinical Pharmacology, 3rd Edition,Arthur Atkinson, Jr.,Shiew-Mei Huang,Juan Lertora,Sanford Markey,ISBN9780123854711

Atkinson, Jr.   &   Huang   &   Lertora   &   Markey   

Academic Press




276 X 216

A valuable resource covering the science of drug discovery and development as it relates to individual patient therapy.

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Key Features

* Includes new chapters on imaging and the pharmacogenetic basis of adverse drug reactions.
* Offers an expanded regulatory section that addresses US and international issues and guidelines.
* Provides extended coverage of earlier chapters on transporters, pharmacogenetics and biomarkers and also illustrates the impact of gender on drug response.
* Presents a broadened discussion of clinical trials from Phase 1 to incorporate Phases II and III.


Principles of Clinical Pharmacology is a successful survey covering the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development. This essential reference continues to focus on the basics of clinical pharmacology for the development, evaluation, and clinical use of pharmaceutical products while also addressing the most recent advances in the field. Written by leading experts in academia, industry, clinical and regulatory settings, the third edition has been thoroughly updated to provide readers with an ideal reference covering the wide range of important topics impacting clinical pharmacology as the discipline plays an increasingly significant role in drug development and regulatory science.


The Third Edition has been endorsed by the American Society for Clinical Pharmacology and Therapeutics


Clinical pharmacologists, pharmacologists, clinicians and scientists working in the pharmaceutical industry and government regulatory agencies

Arthur Atkinson, Jr.

Affiliations and Expertise

Northwestern University, Chicago, Illinois , U.S.A.

Shiew-Mei Huang

Affiliations and Expertise

FDA, Silver Spring, Maryland, U.S.A.

Juan Lertora

Affiliations and Expertise

NIH Clinical Center, Bethesda, MD, U.S.A.

Sanford Markey

Affiliations and Expertise

National Institute of Mental Health, Bethesda, Maryland, U.S.A.

Principles of Clinical Pharmacology, 3rd Edition

Tentative TOC:
Chapter 1 Introduction
Chapter 2 Clinical pharmacokinetics
Chapter 3 Compartmental analysis of drug distribution
Chapter 4 Drug absorption and bioavailability
Chapter 5 Effects of renal disease on pharmacokinetics
Chapter 6 Kinetics of hemodialysis and hemofiltration
Chapter 7 Effects of liver disease on pharmacokinetics
Chapter 8 Noncompartmental vs. compartmental approaches to pharmacokinetic analysis
Chapter 9 Distributed models of drug kinetics
Chapter 10 Population pharmacokinetics
Chapter 11 Pathways of drug metabolism
Chapter 12 Biochemical mechanisms of drug toxicity
Chapter 13 Chemical assay of drugs and drug metabolites
Chapter 14 Equilibrative and concentrative transport
Chapter 15 Pharmacogenetics
Chapter 16 Drug interactions
Chapter 17 Physiological and laboratory markers of drug effect
Chapter 18 Dose response and concentration response analysis
Chapter 19 Kinetics of pharmacologic effect
Chapter 20 Disease progression models
Chapter 21 Sex differences in pharmacokinetics and pharmacodynamics
Chapter 22 Drug therapy in pregnant and nursing women
Chapter 23 Drug therapy in neonates and pediatric patients
Chapter 24 Drug therapy in the elderly
Chapter 25 Clinical analysis of adverse drug reactions
Chapter 26 Quality assessment of drug therapy
Chapter 27 Project management
Chapter 28 Drug discovery
Chapter 29 Pre-clinical development
Chapter 30 Animal scale up
Chapter 31 Phase I studies
Chapter 32 PK and PD considerations in the development of biotechnology products and large molecules
Chapter 33 Design of clinical development programs
Chapter 34 Good design practices for clinical trials
Chapter 35 Role of the FDA in guiding drug development
Appendix I Table of Laplace Transforms
Appendix II Answers to Study Problems

Quotes and reviews

"…this is an excellent textbook that provides a comprehensive overview of the fundamentals and state of the art of clinical pharmacology. It will be an invaluable reference source for many current and future scientists in the field."--Clinical Pharmacology & Therapeutics, June 2013
"Recent advances in pharmacogenetics, membrane transport, and biotechnology warrant a second edition of this excellent book...This will serve as an excellent text for an advanced course in principles of clinical pharmacology for graduate students, physicians, and PharmDs. Because of recent advances, the second edition is welcome."--Thomas L. Pazdernik, PhD, University of Kansas Medical Center, FOR DOODY'S (4 Stars)

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