Therapeutic Drug Monitoring

Therapeutic Drug Monitoring, 1st Edition

Newer Drugs and Biomarkers

Therapeutic Drug Monitoring, 1st Edition,Amitava Dasgupta,ISBN9780123854674

A Dasgupta   

Academic Press




235 X 191

An essential resource that integrates pharmacogenomics and the application of biomarkers to illustrate the current practice of therapeutic drug monitoring

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Key Features

  • Includes both the technical and clinical issues associated with therapeutic drug monitoring.

  • Discusses the utility of therapeutic drug monitoring of newer drugs such as antiretroviral agents, anticonvulsants, antidepressants etc.

  • Provides up-to-date information on issues in pharmacogenomics and personalized medicine with emphasis on therapy with warfarin, certain anticancer drugs and antidepressants.

  • Covers important content on the limitations of commercially available immunoassays (chemical tests) for therapeutic drug monitoring and additional analytical techniques.


Therapeutic Drug Monitoring: Newer Drugs and Biomarkers features timely topics such as the monitoring of classical and newer drugs, pharmacogenomics and the application of biomarkers in therapeutic drug monitoring. This reference also discusses the limitations of current commercially available immunoassays for therapeutic monitoring. It presents new and sophisticated techniques used for proper determination of blood levels and the clinical utility of therapeutic drug monitoring of contemporary drugs. Written by leading international experts and geared toward clinical pathologists, toxicologists, clinical chemists, laboratory professionals and physicians, this book is an essential resource on the current practice of therapeutic drug monitoring in improving patient safety.


The primary target market for this book includes clinical pathologists, toxicologists, pharmacologists, laboratory professionals and clinical chemists.

Amitava Dasgupta

Amitava Dasgupta received his PhD degree in Chemistry from Stanford University and his fellowship training in Clinical Chemistry from the Laboratory Medicine Department of the University of Washington School of Medicine at Seattle. He is a tenured Full Professor of Pathology and Laboratory Medicine at the University of Texas Health Sciences Center located at the Texas Medical Center at Houston. Dr. Dasgupta has published 210 scientific papers, written many invited review articles, and has edited, co-edited or written 15 books. He is on the Editorial Board of five major medical journals including American Journal of Clinical Pathology, Archives of Pathology and Laboratory Medicine, Therapeutic Drug Monitoring, Clinica Chimica Acta and Journal of Clinical Laboratory Analysis.

Affiliations and Expertise

Professor, Pathology and Laboratory Medicine, University of Texas Health Science Center, Houston, TX, USA

View additional works by Amitava Dasgupta

Therapeutic Drug Monitoring, 1st Edition

Chapter 1. Introduction to Therapeutic Drug Monitoring: Frequently and Less Frequently Monitored Drugs

Amitava Dasgupta, Ph.D.

Chapter 2. Effects of Pre-Analytical Variables in Therapeutic Drug Monitoring

Valerie Bush, Ph.D.

Chapter 3. Analytical Techniques used in Therapeutic Drug Monitoring

Michael C. Milone, MD, Ph.D.

Chapter 4. Clinical Utility of Free Drug Monitoring

Marcel Musteata, Ph.D.

Chapter 5. Current Practice of Therapeutic Drug Monitoring: Dose Adjustment of Drugs using Pharmacokinetic models

Franck Saint-Marcoux, Ph.D.

Chapter 6. An Introduction to Personalized Medicine

Annjanette Stone, B.S. and Joshua Bornhorst, Ph.D.

Chapter 7. Application of Ultra-High Throughput Sequencing and Microarray Technologies in Pharmacogenomics Testing

Gary Hardiman, Ph.D.

Chapter 8. Pharmacogenomics and Warfarin therapy

Jenny Martin, PharmD. and Andre Somogyi, PharmD.

Chapter 9. Applications of Pharmacokinetic and Pharmacodynamic Principles to Optimize Drug Dosage Selection: Example of Antibiotic Therapy Management

Jill Butterfield, PharmD., Thomas P. Lodise, Jr., PharmD., Manjunath P. Pai, PharmD.

Chapter 10. Guidelines for Monitoring of Vancomycin, Aminoglycosides and certain antibiotics

Ronald W. McLawhon, M.D., Ph.D.

Chapter 11. Challenges in Therapeutic Drug Monitoring of Digoxin and other Antiarrhythmic Drugs

Amitava Dasgupta, Ph.D.

Chapter 12. Therapeutic Drug Monitoring of Classical and Newer Anticonvulsants

Matthew Luke, M.D., University of New Mexico. Albuquerque, NM

Chapter 13. Challenges in Therapeutic Drug Monitoring of Classical Tricyclic and Newer Antidepressants: Analytical and Pharmacogenetics Considerations

Uttam Garg, Ph.D. and Angela Ferguson, Ph.D.

Chapter14. Therapeutic Drug Monitoring of Selected Anticancer Drugs: Pharmacogenomics issues

Michael C. Milone, MD, Ph.D.

Chapter 15. Immunosuppressive Drug Monitoring: Limitations of Immunoassays and the Application of Liquid Chromatography Mass Spectrometry

Kathleen A. Kelly, Ph.D. and Anthony W. Butch, Ph.D.

Chapter 16. Biomarkers: The Link between Therapeutic Drug Monitoring and Pharmacodynamics of Immunosuppressants

Michael Oellerich, M.D., Gunnar Brandhorst, M.D., Maria Shipkova, M.D., Eberhard Wieland, M.D.

Chapter 17. Therapeutic Drug Monitoring of Antiretroviral Drugs in the Management of Human Immunodeficiency Infection

Natella Y. Rakhmanina, MD, PhD., Charles J.L. la Porte, PharmD., Ph.D.

Chapter 18. Drug Testing in Pain Management

Roger L. Bertholf, Ph.D., and Gary M. Reisfield, MD

Chapter 19. Role of Therapeutic Drug Monitoring to Identify Clinically Significant Drug-Herbal Supplement Interaction

Alex C. Chin, Ph.D., Leland B. Baskin, M.D.

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