Principles of Molecular Virology, 5th Edition

Principles of Molecular Virology, 5th Edition,Alan Cann,ISBN9780123849397


Academic Press




240 X 197

Provides an essential introduction to modern virology.

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Key Features

  • Completely rewritten and updated
  • Clear and easy to understand
  • Examples covering important ideas in virology
  • All new illustrations
  • Accompanying website with interactive resources and teaching material for instructors


Principles of Molecular Virology, Fifth Edition, provides an introduction to modern virology. Viruses are submicroscopic, obligate intracellular parasites that are more diverse than all the bacterial, plant, and animal kingdoms combined. The book examines protein-protein, protein-nucleic acid, and protein-lipid interactions, which control the structure of virus particles; the ways in which viruses infect cells; how viruses replicate; and the effects of virus infection on host organisms. The book begins with a history of virology, tracing the development of knowledge and research on virology. The remaining seven chapters deal with the function and formation of virus particles; the structure and complexity of virus genomes; virus replication; gene expression; virus infections; the effects of virus infection on the body and the body’s response to infection; and subviral agents, such as satellites, viroids, and prions. The text concludes with three appendices that feature a glossary and abbreviations; a classification of subcellular infectious agents; and an outline of the history of virology.


Undergraduates and graduates in virology, molecular biology and microbiology; Medical students and infectious disease clinicians and immunologists; Those entering the virology research area, including plant virology and AIDS research

Alan Cann

Dr. Alan J. Cann has worked in both the U.K. and U.S.A. teaching undergraduate, postgraduate, and medical students. He is currently a Senior Lecturer in Biological Sciences at the University of Leicester where his research interests include pedagogic research and science communication.

Affiliations and Expertise

Senior Lecturer, Department of Microbiology and Immunology, University of Leicester, U.K.

Principles of Molecular Virology, 5th Edition

Preface to the Fifth Edition Chapter 1 Introduction What Are Viruses? Are viruses alive? The History of Virology Living Host Systems Cell Culture Methods Serological/Immunological Methods Ultrastructural Studies Molecular Biology Summary Chapter 2 Particles The Function and Formation of Virus Particles Capsid symmetry and virus architecture Helical capsids Icosahedral (isometric) capsids Enveloped viruses Complex virus structures Protein-nucleic acid interactions and genome packaging Virus receptors: recognition and binding Other interactions of the virus capsid with the host cell Summary Chapter 3 Genomes The Structure and Complexity of Virus Genomes Molecular genetics Virus genetics Virus mutants Genetic interactions between viruses Nongenetic interactions between viruses Small DNA genomes Large DNA genomes Positive-strand RNA viruses Negative-strand RNA viruses Segmented and multipartite virus genomes Reverse transcription and transposition Evolution and epidemiology Summary Chapter 4 Replication Overview of Virus Replication Investigation of Virus Replication The Replication Cycle Attachment Penetration Uncoating Genome replication and gene expression Assembly Maturation Release Summary Chapter 5 Expression Expression of Genetic Information Control of Prokaryote Gene Expression Control of Expression in Bacteriophage ? Control of Eukaryote Gene Expression Genome Coding Strategies Class I: Double-stranded DNA Class II: Single-stranded DNA Class III: Double-stranded RNA Class IV: Single-stranded (+)sense RNA Class V: Single-stranded (-)sense RNA Class VI: Single-stranded (+)sense RNA with DNA intermediate Class VII: Double-stranded DNA with RNA intermediate Transcriptional Control of Expression Posttranscriptional Control of Expression Summary Chapter 6 Infection Virus Infections of Plants Immune Responses to Virus Infections in Animals Viruses and Apoptosis Interferons Evasion of Immune Responses by Viruses Inhibition of MHC-I-restricted antigen presentation Inhibition of MHC-II-restricted antigen presentation Inhibition of natural killer cell lysis Interference with apoptosis Inhibition of cytokine action Evasion of humoral immunity Evasion of the complement cascade Virus-Host Interactions The Course of Virus Infections Abortive infection Acute infection Chronic infection Persistent infection Latent infection Prevention and Therapy of Virus Infection RNA Interference (RNAi) Virus Vectors and Gene Therapy Chemotherapy of Virus Infections Summary Chapter 7 Pathogenesis Mechanisms of Cellular Injury Viruses and Immunodeficiency Virus-Related Diseases Bacteriophages and Human Disease Cell Transformation by Viruses Cell Transformation by Retroviruses Cell Transformation by DNA Viruses Viruses and Cancer New and Emergent Viruses Zoonoses Bioterrorism Summary Chapter 8 Subviral Agents: Genomes without Viruses, Viruses without Genomes Satellites and Viroids Prions Pathology of prion diseases TSE in Animals Scrapie Transmissible mink encephalopathy (TME) Feline spongiform encephalopathy (FSE) Chronic wasting disease (CWD) Bovine spongiform encephalopathy (BSE) Human TSES Molecular Biology of Prions Summary Appendix 1: Glossary and Abbreviations Appendix 2: Classification of Subcellular Infectious Agents Appendix 3: The History of Virology Index

Quotes and reviews

Praise for previous editions:
“An excellent virological text for students. It is recommended in many university undergraduate courses for good reason. It is well written in an accessible style... well illustrated…I suspect the self assessment questions will be usefully plundered by those setting examinations.” - Trends in Genetics
“Excellent.. The writing flows easily with good practical examples... an attractive, up-to-date book and is an excellent buy that I can strongly recommend.” - Society for General Microbiology Quarterly
"More suitable for an undergraduate class than any other text I have recently seen... readable and undergraduate-friendly, and it fills a definite niche.” - American Society for Microbiology News
"Compact... and realistically priced... Present(s) molecular virology to an undergraduate audience is an easily digestible form.” - Trends in Microbiology

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