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Human Chorionic Gonadotropin (hGC)
 
 

Human Chorionic Gonadotropin (hGC), 1st Edition

 
Human Chorionic Gonadotropin (hGC), 1st Edition,Larry Cole,ISBN9780123849076
 
 
 

  

Elsevier

9780123849076 New edition

9780123849083

400

229 X 152

A comprehensive and in depth review of the role of hCG

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Key Features

  • It provides comprehensive information on hCG from basic science to clinical medicine

  • Written by specialists in the field

Description

Human chorionic gonadotropin (hCG) is produced during pregnancy by the embryo. It promotes progesterone production by corpus luteal cells. It also functions in pregnancy to promote angiogenesis in uterine vasculature, it immuno-blands the invading placental tissue so it is not rejected by the maternal uterine tissues, promotes the growth of the uterus in line with the growth of the fetus, promotes the differentiation of growing cytotrophoblast cells, promotes the quiescence of contractions in the uterine myometrium during the course of pregnancy, and also has function in growth and development of fetal organs.

The book describes the detailed biology, clinical chemistry, and clinical perspectives of hCG and associated molecules, and examines hCG, hyperglycosylated hCG and hCG free ß-subunit, 3 separate and independent molecules with totally sovereign physiological functions.

Readership

Researchers and clinicians in obstetrics, gynecology, clinical chemistry, endocrinology, reproductive medicine and oncology

Larry Cole

Affiliations and Expertise

The Howard and Friedman Distinguished Professor of Obstetrics and Gynecology, University of New Mexico, USA

Human Chorionic Gonadotropin (hGC), 1st Edition

INTRODUCTION

 Chapter 1: THE EXPANDING WORLD OF hCG

Robert Hussa

Chapter 2: HISTORY AND INTRODUCTION TO HUMAN CHORIONIC GONADOTROPIN (hCG): ONE NAME FOR AT LEAST THREE INDEPENDENT MOLECULES
Laurence Cole

Chapter 3: INTRODUCTION TO PREGNANCY IMPLANTATION, VILLOUS FORMATION, AND HEMOCHORIAL PLACENTATION
Laurence Cole

 GENETICS, SYNTHESIS, SECRETION, STRUCTURE, AND DEGRADATION OF hCG

Chapter 4: THE MOLECULAR GENETICS OF hCG
Stephen Butler

Chapter 5: STRUCTURE, SYNTHESIS, SECRETION, AND FUNCTION OF hCG
Laurence Cole, PhD and Stephen Butler

Chapter 6: COMPARISSON OF STRUCTURES OF hCG AND HYPERGLYCOSYLATED hCG
Laurence Cole

Chapter 7: STRUCTURES OF FREE a-SUBUNIT AND FREE ß-SUBUNIT
Laurence Cole

Chapter 8: GLYCOBIOLOGY OF hCG
Akira Kobata

Chapter 9: DEGRADATION PRODUCTS OF hCG, HYPERGLYCOSYLATED hCG, AND FREE ß-SUBUNIT
Laurence Cole

Chapter 10: THE THREE DIMENSIONAL STRUCTURE OF hCG
Laurence Cole

 

BIOLOGICAL FUNCTION OF hCG

Chapter 11: PARADIGM SHIFT ON THE TARGETS OF hCG ACTIONS

CV Rao

Chapter 12: THE hCG RECEPTOR

Laurence Cole and Stephen Butler

Chapter 13: BIOLOGICAL FUNCTIONS OF HYPERGLCOSYLATED hCG
Laurence Cole

Chapter 14: BIOLOGICAL FUNCTION OF THE FREE BETA SUBUNIT: EXPRESSION AND TREATMENT TARGET IN CANCER

Steven Butler and Ray Iles

 

CLINICAL APPLICATIONS

Chapter 15: USE OF hCG IN REPRODUCTIVE DYSFUNCTION
Cisco Byrn

Chapter 16: hCG IN THE IVF CLINIC
Ervin Jones,

Chapter 17: ILLICIT USE OF hCG IN DIETARY PROGRAMS AND USE TO PROMOTE ANABOLISM
Laurence Cole

 

hCG TESTS

Chapter 18: ANTIBODYS FOR INTACT hCG, TOTAL hCG, FREE SUBUNITS, GLYCOSYLATION VARIANTS, AND hCG FRAGMENTS
Laurence Cole

Chapter 19: QUANTITATIVE hCG ASSAYS
Laurence Cole

Chapter 20: FALSE-POSITIVE hCG ASSAYS
Laurence Cole

Chapter 21: SPECIFICITY OF DIFFERENT hCG ASSAYS
Laurence Cole

Chapter 22: POINT-OF-CARE PREGNANCY TESTS
Laurence Cole

Chapter 23: OVER-THE-COUNTER PREGANCY TESTS
Laurence Cole

Chapter 24: hCG STANDARDS
Ulf Stenman

 

TEST APPLICATIONS

Chapter 25: BACKGROUND hCG
Laurence Cole

Chapter 26: PREGNANCY TESTING
Laurence Cole

Chapter 27: PREDICTING SPONTANEOUSLY ABORTED (SAB) PREGNANCIES
Laurence Cole

Chapter 28: hCG, HYPERGLYCOSYLATED hCG, AND FREE ß-SUBUNIT IN PREDICTING DOWN SYNDROME PREGNANCIES AND PREECLAMPSIA
Laurence Cole

Chapter 29: hCG IN MONITORING GESTATIONAL TROPHOBLASTIC DISEASES

Laurence Cole

Chapter 30: USE OF HYPERGLYCOSYLATED hCG AS A UNIQUE MARKER OF GESTATIONAL TROPHOBLASTIC NEOPLASMS

Laurence Cole and Carolyn Muller

Chapter 31: PITUITARY hCG AND FAMILIAL hCG
Laurence Cole

Chapter 32: hCG, FREE ß-SUBUNIT AND ß-CORE FRAGMENT AS MARKERS OF MALIGNANCIES
Laurence Cole

 

BASIC METHODS

Chapter 33: hCG AND HYPERGLYCOSYLATED HCG PURIFICATION FROM SERUM, URINE, AND CULTURE FLUIDS

Laurence Cole

Chapter 34: DISSOCIATION, DESIALYLATION, AND CLEAVAGE OF HCG

Laurence Cole

Chapter 35: hCG AND FREE ß-SUBUNIT PRODUCING CELL LINES

Laurence Cole

  

EVOLUTION, SUMMARY AND THE FUTURE

Chapter 36: EVOLUTION OF hCG, EVOLUTION OF HUMANS, EVOLUTION OF HUMAN PREGNANCY DISORDERS AND CANCER
Laurence Cole

Chapter 37: SUMMARY: hCG A REMARKABLE MOLECULE
Laurence Cole

Chapter 38: hCG AND THE FUTURE
Laurence Cole

 
 
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