Regenerative Biology and Medicine

Regenerative Biology and Medicine, 2nd Edition

Regenerative Biology and Medicine, 2nd Edition,David Stocum,ISBN9780123848604


Academic Press




276 X 216

Winner of a 2013 Highly Commended BMA Medical Book Award for Medicine

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Key Features

  • Highly Commended 2013 BMA Medical Book Award for Medicine
  • Includes coverage of skin, hair, teeth, cornea, and central neural tissues
  • Provides description of regenetive medicine in digestive, respiratory, urogenital, musculoskeletal, and cardiovascular systems
  • Includes amphibians as powerful research models with discussion of appendage regeneration in amphibians and mammals


Regenerative Biology and Medicine, Second Edition - Winner of a 2013 Highly Commended BMA Medical Book Award for Medicine - discusses the fundamentals of regenerative biology and medicine. It provides a comprehensive overview, which integrates old and new data into an ever-clearer global picture. The book is organized into three parts. Part I discusses the mechanisms and the basic biology of regeneration, while Part II deals with the strategies of regenerative medicine developed for restoring tissue, organ, and appendage structures. Part III reflects on the achievements of regenerative biology and medicine; future challenges; bioethical issues that need to be addressed; and the most promising developments in regenerative medicine. The book is designed for multiple audiences: undergraduate students, graduate students, medical students and postdoctoral fellows, and research investigators interested in an overall synthesis of this field. It will also appeal to investigators from fields not directly related to regenerative biology and medicine, such as chemistry, informatics, computer science, mathematics, physics, and engineering.


Researchers and students in biology, chemistry, and bioengineering; medical students; academic and clinical physicians; and research investigators

David Stocum

Affiliations and Expertise

Department of Biology, Indiana University-Purdue University Indianapolis, USA

View additional works by David L. Stocum

Regenerative Biology and Medicine, 2nd Edition

Preface Part I Regenerative Biology 1. An Overview of Regenerative Biology I. Introduction II. A Brief History of Regenerative Biology III. Regeneration Occurs at All Levels of Biological Organization IV. Mechanisms of Vertebrate Regeneration V. The Niche Concept in Tissue Repair VI. Approaches to the Study of Regeneration Summary References 2. Repair of Skin by Fibrosis I. Introduction II. Structure of Adult Mammalian Skin III. Phases of Repair By Fibrosis IV. Tattoos and Fetal Skin Have a Minimal Immune Response to Wounding V. Comparative Molecular Analysis of Wound Repair Summary References 3. Regeneration of Epidermal Structures I. Introduction II. Maintenance Regeneration of Interfollicular Epidermis and Hair III. Regeneration of Nails IV. Regeneration of Cornea V. Regeneration of the Lens VI. Regeneration of Avian and Mammalian Auditory Sensory Cells Summary References 4. Regeneration of Neural Tissues I. Introduction II. Structure of the Nervous System III. Regeneration of Axons IV. Neurogenesis in the Adult CNS Summary References 5. Regeneration of Digestive, Respiratory and Urinary Tissues I. Introduction II. Regeneration of the Intestinal Epithelium III. Regeneration of the Liver IV. Regeneration of the Pancreas V. Regeneration of Respiratory Epithelium VI. Regeneration of Kidney Tubule Epithelium Summary References 6. Regeneration of Musculoskeletal Tissues I. Introduction II. Regeneration of Skeletal Muscle III. Regeneration of Bone IV. Regeneration of Articular Cartilage, Meniscus, Tendon and Ligament V. Regeneration of Dental Tissues Summary References 7. Regeneration of Cardiac Muscle and Hematopoietic Tissues I. Introduction II. Regeneration of Cardiac Muscle III. Regeneration of Hematopoietic Cells Summary References 8. Regeneration of Appendages I. Introduction II. Urodele Limb Regeneration III. What Inhibits Limb Regeneration in Adult Frogs, Birds and Mammals? IV. Regeneration of Mammalian Appendages V. Stimulation of Regeneration in Anuran and Mammalian Appendages VI. Comparative Analysis as a Tool to Understand Limb Regeneration Summary References Part II Regenerative Medicine 9. Strategies of Regenerative Medicine I. Introduction II. Biomimetic Devices and Organ Transplant III. Cell Transplants IV. Bioartificial Tissue Construction V. Chemical Induction of Regeneration in situ Summary References 10. Regenerative Medicine of Epidermal Structures I. Introduction II. Repair of Skin Wounds and Burns III. Stimulation of Hair Regeneration IV. Limbal Cell Transplants to Regenerate the Cornea Summary References 11. Regenerative Medicine of Neural Tissues I. Introduction II. Therapies for Regeneration of Peripheral Nerves III. Therapies for Trauma to the Mammalian Central Nervous System IV. Therapies for Neurodegenerative Diseases Summary References 12. Regenerative Therapies for Digestive, Respiratory and Urinary Tissues I. Introduction II. Regenerative Therapies for the Liver III. Regenerative Therapies for the Pancreas IV. Regenerative Therapies for the Esophagus and Intestine V. Regenerative Therapies for the Respiratory System VI. Regenerative Therapies for the Urinary System Summary References 13. Regenerative Therapies for Musculoskeletal Tissues I. Introduction II. Therapies for Skeletal Muscle III. Regenerative Therapies for Articular Cartilage IV. Regenerative Therapies for Meniscus V. Regenerative Therapies for Non-Union Fractures and Critical Size Gaps in Bone VI. Regenerative Therapies for Teeth and Periodontium VII. Regenerative Therapies for Tendon and Ligament Summary References 14. Regenerative Therapies for Hematopoietic and Cardiovascular Tissues I. Introduction II. Therapies for Hematopoietic Disorders III. Therapies for Damaged Blood Vessels IV. Therapies for Infarcted Myocardium Summary References Part III Perspective 15. Retrospect and Prospect I. Introduction II. Achievements and Challenges III. Bioethics in Regenerative Medicine IV. Exciting Future Prospects for Regenerative Biology and Medicine V. Concluding Remarks References Index

Quotes and reviews

"...a terrific reference for anyone toying with the idea of moving into this field. The text offers an enormous breath of coverage of different systems currently under investigation, and Stocum provides a central theme that pits regenerative ability against fibrosis as a way to conceptually untangle the limited regenerative capacity of humans...Stocum has erected an umbrella large enough for scientists of diverse backgrounds to initiate conceptual cross-talk between those actively involved in the biology of regeneration and those targeting its clinical application."
- Ken Muneoka, Department of Cell and Molecular Biology, Tulane University, New Orleans, Louisiana

“…of tremendous importance to researchers and clinicians working in the fields of regeneration and stem cell biology.”
- Jonathan Henry, University of Illinois at Urbana-Champaign

“This text integrates information from cell and developmental biology with regenerative biology, tissue engineering and clinical practice. The breadth and detail of this intellectual landscape are derived from the author’s long commitment to the problems of regeneration, and help to make this volume a landmark publication for regenerative medicine.”
- Jeremy Brockes, University College London

“This book is a superb in-depth analysis of the existing potential of the tissues of the body to replace cells and tissues and how to promote this ability for the sake of repair….Every institute should have it as their background reading and mission statement. I can't recommend it highly enough, it has been long awaited.”
- Malcolm Maden, King’s College London

“…wonderful and comprehensive, providing readers with the basis of regeneration biology and medicine. The author emphasizes the necessity of understanding the biology of regeneration for a true appreciation of its practice in clinical medicine.”
- Katsutoshi Yoshizato, University of Hiroshima
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