Quantitative Human Physiology

Quantitative Human Physiology, 1st Edition

An Introduction

Quantitative Human Physiology, 1st Edition,Joseph Feher,ISBN9780123821638


Academic Press




281 X 222

This text provides the engineering student with a basic understanding of physiological principles with an emphasis on quantitative aspects. It teaches the language of physiology, both qualitative and quantitative, and highlights how component behavior affects system behavior.

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Key Features

  • A quantitative approach that includes physical and chemical principles
  • An integrated approach from first principles, integrating anatomy, molecular biology, biochemistry and physiology. Illustration program reinforces the integrated nature of physiological systems
  • Pedagogically rich, including chapter objectives, chapter summaries, large number of illustrations, and short chapters suitable for single lectures
  • Clinical applications relevant to the biomedical engineering student (TENS, cochlear implants, blood substitutes, etc.)
  • Problem sets provide opportunity for practice and assessment throughout the course.


Quantitative Human Physiology: An Introduction presents a course in quantitative physiology developed for undergraduate students of Biomedical Engineering at Virginia Commonwealth University. The text covers all the elements of physiology in nine units: (1) physical and chemical foundations; (2) cell physiology; (3) excitable tissue physiology; (4) neurophysiology; (5) cardiovascular physiology; (6) respiratory physiology; (7) renal physiology; (8) gastrointestinal physiology; and (9) endocrinology. The text makes extensive use of mathematics at the level of calculus and elementary differential equations. Examples and problem sets are provided to facilitate quantitative and analytic understanding, while the clinical applications scattered throughout the text illustrate the rationale behind the topics discussed. This text is written for students with no knowledge of physiology but with a solid background in calculus with elementary differential equations. The text is also useful for instructors with less time; each chapter is intended to be a single lecture and can be read in a single sitting.


undergraduate bioengineering students

Joseph Feher

Affiliations and Expertise

Virginia Commonwealth University

Quantitative Human Physiology, 1st Edition

Preface Acknowledgments Unit 1 Physical and Chemical Foundations of Physiology Chapter 1.1 The Core Principles of Physiology Chapter 1.2 Physical Foundations of Physiology I: Pressure-Driven Flow Chapter 1.3 Physical Foundations of Physiology II: Electrical Force, Potential, Capacitance, and Current Problem Set 1.1 Physical Foundations: Pressure and Electrical Forces and Flows Chapter 1.4 Chemical Foundations of Physiology I: Chemical Energy and Intermolecular Forces Chapter 1.5 Chemical Foundations of Physiology II: Concentration and Kinetics Chapter 1.6 Diffusion Chapter 1.7 Electrochemical Potential and Free Energy Problem Set 1.2 Kinetics and Diffusion Unit 2 Membranes, Transport, and Metabolism Chapter 2.1 Cell Structure Chapter 2.2 DNA and Protein Synthesis Chapter 2.3 Protein Structure Chapter 2.4 Biological Membranes Problem Set 2.1 Surface Tension, Membrane Structure, Microscopic Resolution, and Cell Fractionation Chapter 2.5 Passive Transport and Facilitated Diffusion Chapter 2.6 Active Transport: Pumps and Exchangers Chapter 2.7 Osmosis and Osmotic Pressure Problem Set 2.2 Membrane Transport Chapter 2.8 Cell Signaling Chapter 2.9 ATP Production I: Glycolysis Chapter 2.10 ATP Production II: The TCA Cycle and Oxidative Phosphorylation Chapter 2.11 ATP Production III: Fatty Acid Oxidation and Amino Acid Oxidation Unit 3 Physiology of Excitable Cells Chapter 3.1 The Origin of the Resting Membrane Potential Chapter 3.2 The Action Potential Chapter 3.3 Propagation of the Action Potential Problem Set 3.1 Membrane Potential, Action Potential, and Nerve Conduction Chapter 3.4 Skeletal Muscle Mechanics Chapter 3.5 Contractile Mechanisms in Skeletal Muscle Chapter 3.6 The Neuromuscular Junction and Excitation-Contraction Coupling Chapter 3.7 Muscle Energetics, Fatigue, and Training Problem Set 3.2 Neuromuscular Transmission, Muscle Force, and Energetics Chapter 3.8 Smooth Muscle Unit 4 The Nervous System Chapter 4.1 Organization of the Nervous System Chapter 4.2 Cells, Synapses, and Neurotransmitters Chapter 4.3 Cutaneous Sensory Systems Chapter 4.4 Spinal Reflexes Chapter 4.5 Balance and Control of Movement Problem Set 4.1 Nerve Conduction Chapter 4.6 The Chemical Senses Chapter 4.7 Hearing Chapter 4.8 Vision Problem Set 4.2 Sensory Transduction Chapter 4.9 Autonomic Nervous System Unit 5 The Cardiovascular System Chapter 5.1 Overview of the Cardiovascular System and the Blood Chapter 5.2 Plasma and Red Blood Cells Chapter 5.3 White Blood Cells and Inflammation Chapter 5.4 The Heart as a Pump Problem Set 5.1 Blood Chapter 5.5 The Cardiac Action Potential Chapter 5.6 The Electrocardiogram Chapter 5.7 The Cellular Basis of Cardiac Contractility Chapter 5.8 The Cardiac Function Curve Problem Set 5.2 Cardiac Work Chapter 5.9 Vascular Function: Hemodynamics Chapter 5.10 The Microcirculation and Solute Exchange Chapter 5.11 Regulation of Perfusion Chapter 5.12 Integration of Cardiac Output and Venous Return Chapter 5.13 Regulation of Arterial Pressure Problem Set 5.3 Hemodynamics and Microcirculation Unit 6 Respiratory Physiology Chapter 6.1 The Mechanics of Breathing Chapter 6.2 Lung Volumes and Airway Resistance Chapter 6.3 Gas Exchange in the Lungs Problem Set 6.1 Airway Resistance and Alveolar Gas Exchange Chapter 6.4 Oxygen and Carbon Dioxide Transport Chapter 6.5 Acid-Base Physiology I: The Bicarbonate Buffer System and Respiratory Compensation Chapter 6.6 Control of Ventilation Problem Set 6.2 Gas Transport and pH Disturbances Unit 7 Renal Physiology Chapter 7.1 Body Fluid Compartments Chapter 7.2 Functional Anatomy of the Kidneys and Overview of Kidney Function Chapter 7.3 Glomerular Filtration Problem Set 7.1 Fluid Volumes, Glomerular Filtration, and Clearance Chapter 7.4 Tubular Reabsorption and Secretion Chapter 7.5 Mechanism of Concentration and Dilution of Urine Chapter 7.6 Regulation of Fluid and Electrolyte Balance Chapter 7.7 Renal Component of Acid-Base Balance Problem Set 7.2 Fluid and Electrolyte Balance and Acid-Base Balance Unit 8 Gastrointestinal Physiology Chapter 8.1 Mouth and Esophagus Chapter 8.2 The Stomach Chapter 8.3 Intestinal and Colonic Motility Chapter 8.4 Pancreatic and Biliary Secretion Chapter 8.5 Digestion and Absorption of the Macronutrients Chapter 8.6 Energy Balance and Regulation of Food Intake Problem Set 8.1 Energy Balance Unit 9 Endocrine Physiology Chapter 9.1 General Principles of Endocrinology Chapter 9.2 Hypothalamus and Pituitary Gland Chapter 9.3 The Thyroid Gland Chapter 9.4 The Endocrine Pancreas and Control of Blood Glucose Chapter 9.5 The Adrenal Cortex Chapter 9.6 The Adrenal Medulla and Integration of Metabolic Control Chapter 9.7 Calcium and Phosphorus Homeostasis I: The Calcitropic Hormones Chapter 9.8 Calcium and Phosphorus Homeostasis II: Target Tissues and Integrated Control Chapter 9.9 Female Reproductive Physiology Chapter 9.10 Male Reproductive Physiology Problem Set 9.1 Ligand Binding Appendix I Important Equations Appendix II Important Physical Constants for Physiology Index

Quotes and reviews

".. in terms of what is out there this book provides the best mix I have seen thus far of balancing the two aspects of "quantitative" "physiology" - Professor Sean Collins at University of Massachusetts - Lowell


"It would be quite useful for engineers who want to ply their trade in the physiological sciences.....  I have been looking for this kind of book for a long time. I am going to show it also to more of my mathematical colleagues. I am still evaluating it and reading it myself-but I love the approach. The author needs to be congratulated for a masterpiece of a work." - Professor Lawrence Basso, MD, Stanford University


"This book is long-overdue for combined teaching of a course that moves from cellular to systems physiology that truly integrates the quantitation with the physiology. It is an extremely easily read book that covers all aspects of physiology, from the mathematical concepts that underlie how human physiology functions to medically-related diseases and conditions, as well as current medical treatments. I plan to utilize this book for upper level undergraduate biomedical engineering students in sensory and quantitative physiology, as well as for advanced graduate students in a pharmacological and physiological PhD program in medical school, with appropriate emphasis from the book for each student group according to their needs and abilities." - Amy B. Harkins, Associate Professor, Saint Louis University


“Complements to Dr. Feher-the book is excellent and the students are benefiting.” - Dr. David Reinkensmeyer, University of California, Irvine

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