Essential Neuromodulation

Essential Neuromodulation, 1st Edition

Essential Neuromodulation, 1st Edition,Jeffrey Arle,Jay Shils,ISBN9780123814098

Arle   &   Shils   

Academic Press




229 X 152

The only concise, practical reference to address the clinical implications of neuromodulation therapy, its mechanisms, devices, and their management.

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Key Features

  • Chapters offer point-counterpoint commentary for varied perspectives
  • Appendix distills current guidelines in easy, accessible format
  • Chapters follow story of patient care, effectively emphasizing general principles with supporting examples
  • Offers outstanding scholarship, with over 20% of chapters involving international contributors


Neuromodulation is an emerging field that explores the use of electrical, chemical, and mechanical interventions to heal neurological deficits. Such neurostimulation has already shown great promise with disorders and diseases such as chronic pain, epilepsy, and Parkinson’s disease. This is the first concise reference covering all of the basic principles of neuromodulation in a single affordable volume for neuro-residents, fellows, and basic clinical practitioners, edited by two prominent clinical experts in the field.

This volume emphasizes essential observations from all of the important clinical phases involved in any neuromodulation: targeting, intraoperative assessment, programming, complications, and complication avoidance. There are commonalities to all neuromodulation procedures that must be brought to the forefront to form a cohesive presentation of neuromodulation, and such emphasis will give readers a more solid grounding in the fundamentals needed to embrace this field as a cohesive clinical entity.


Academic clinicians in neurophysiology, neurological diseases, behavioral neuroscience, sensory neuroscience, neuroanatomy and neurosurgery; biomedical engineers looking to understand the clinical aspects of neuro-therapies

Jeffrey Arle

Affiliations and Expertise

Associate Professor of Neurosurgery, Harvard Medical School, Boston, MA, USA

Jay Shils

Affiliations and Expertise

Rush University Medical Center, Director of Intraoperative Neurophysiological Monitoring; Associate Professor, Rush University Medical Center in the Department of Anesthesiology, Chicago, IL, USA

Essential Neuromodulation, 1st Edition

Introduction by Andres Lozano

Section I: The Neuromodulation Approach
1. The Neuromodulation Approach by Jeff Arle

Section II: Regions of Application
2. Cerebral - Surface by Sergio Canavero
3. Cerebral - Deep by Yakov Gologorsky, Ron Alterman
4. Spinal - Extradural by Tim Deer, Mathew Shocket
5. Peripheral Nerve by Konstantin Slavin

Section III: The Neuromodulation Therapy Interface
6. The Electrode - Materials and Configurations by  Daniel Merrill
7. The Electrode - Principles of the Neural Interface: Axons and Cell Bodies by Cameron McIntyre
8. The Electrode - Principles of the Neural Interface: Circuits by Erwin Montgomery
9. The Electrode - Device Materials, Handling and Upgradeability by John Kast, Gabi Molnar, Mark Lent
10. The Electrode - Electronics by Emarit Ranu
11. The Electrode - Power by Tracy Cameron

Section IV: Placing Neuromodulation in the Human Body
12. Surgical Techniques by Jeff Arle
13. Trials and Their Applicability by Lou Raso
14. Limiting Morbidity by Konstantin Slavin

Section V: Troubleshooting and Repair
15.  Intraoperative Evaluation by Jay Shils, Jeff Arle

Section VI: Post-Operative Management
16.  Programming -  DBS and other by Jay Shils
17.  Programming -  SCS by Gabi Molnar, Lisa Johanek, Steve Goetz, John Heitman
18. Safety and Environmental Constraints by Paul Larson, Alastair J. Martin

Section VII: The End User
19.  Expectations and Outcomes by Guillermo A. Monsalve,  Chad W. Farley, George T. Mandybur
20.  Future Design Improvements by Alim-Louis Benabid


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