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GABAb Receptor Pharmacology: A Tribute to Norman Bowery
 
 

GABAb Receptor Pharmacology: A Tribute to Norman Bowery, 1st Edition

 
GABAb Receptor Pharmacology: A Tribute to Norman Bowery, 1st Edition,Thomas Blackburn,ISBN9780123786470
 
 
 

Advances in Pharmacology

T Blackburn   

Academic Press

9780123786470

9780123786487

520

229 X 152

This monograph was assembled to honor Professor Norman Bowery and his work on the 30th anniversary of his discovery of the GABAB receptor, with topics providing a comprehensive review of the field and the current state of research in this area.

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Key Features

  • Articles written by leading investigators in the field
  • Informs and updates on all the latest developments
  • Description

    This monograph was assembled to honor Professor Norman Bowery and his work on the 30th anniversary of his discovery of the GABAB receptor. In the present volume, leading neuroscientists from academia and industry provide a perspective of current research, both basic and translational, in the discovery of drugs acting at the GABAB receptor. The topics covered provide a comprehensive review of the field and the current state of research in this area. Included are chapters on the chemistry of GABAB agonists and antagonists, on the genetics and molecular composition of the site, its regulation and trafficking, and its role in controlling cellular, autonomic, and behavioral function. There are also chapters describing the potential clinical utility of drugs regulating GABAB activity receptor in the areas of hypertension, gastroesophageal reflux disease, Down syndrome, depression, and substance abuse.

    The information contained in this text will be of particular interest to neuroscientists in general and to neuropharmacologists in particular.

    Readership

    The information contained in this text will be of particular interest to neuroscientists in general and to neuropharmacologists in particular.

    Thomas Blackburn

    GABAb Receptor Pharmacology: A Tribute to Norman Bowery, 1st Edition

    1. Historical Perspective and Emergence of the GABAB Receptor
    2. Norman Bowery

    3. Chemistry of GABAB Receptor Ligands
    4. Wolfgang Froestl

    5. Heterodimerization of the GABAB Receptor - Implications for GPCR Signaling and Drug Discovery
    6. Fiona H. Marshall and Steven M. Foord

    7. Mechanisms of GABAB Receptor Exocytosis, Endocytosis and Degradation
    8. Deitmar Benke

    9. Functional Modulation of GABAB Receptors by Protein Kinases and Receptor Trafficking
    10. Miho Terunuma, Andres Couve, Menelas N. Pangalos, and Stephen J. Moss

    11. GABAB Receptor Coupling to G Proteins and Ion Channels
    12. Claire Padgett and Paul A. Slesinger

    13. GABAB Receptor-mediated Modulation of Metabotropic Glutamate Signaling and Synaptic Plasticity in Central Neurons
    14. M. Kano and Toshihide Tabata

    15. GABA Transporter GAT1: A Crucial Determinant of GABAB Receptor Activation in Cortical Circuits?
    16. Guillermo Gonzalez-Burgos

    17. The Role of GABAB Receptors in Cortical Network Activity
    18. Michael M. Kohl and Ole Paulsen

    19. GABAB Receptors: Physiology Functions and Mechanisms of Diversity
    20. Andree Pinard, Riad Seddik, and Bernhard Bettler

    21. Role of GABAB Receptors in Autonomic Control of Systemic Blood Pressure
    22. De-Pei Li and Hui-Lin Pan

    23. GABAB Receptor Agonism as a Novel Therapeutic Modality in the Treatment of Gastroesophageal Reflux Disease
    24. Anders Lehmann, Jorgen Jensen, and Guy E. Boeckxstaens

    25. GABAB Receptors in Reward Processes
    26. Styliani Vlachou and Athina Markou

    27. GABAB Receptors in Addiction and Its Treatment
    28. David J. Nutt, Anne Lingford-Hughes, Laurence John Reed, and Robin J. Tyacke

    29. GABAB - GIRK2 Mediated Signaling in Down Syndrome
    30. Nathan Cramer, Tyler Best, and Zygmunt Galdzicki

    31. GABAB Receptors and Depression: Current Status
    32. John F. Cryan and David A. Slattery

    33. GABAB Receptors in Drosophila

    Hari Manev and Svetlana Dzitoyeva

     
     

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