Handbook of the Biology of Aging, 7th Edition

Key Features

• Contains basic aging processes as determined by animal research as well as medical physiology of aging as known in humans
• Covers hot areas of research, like stem cells, integrated with longstanding areas of interest in aging like telomeres, mitochondrial function, etc.
• Edited by one of the fathers of gerontology (Masoro) and contributors represent top scholars in gerintology

Description

The Handbook of the Biology of Aging, 7e, is 100% revised from the 6^th edition.  Providing a comprehensive synthesis and review of the latest research findings in the biology of aging, it is intended as a summary for researchers, and is also suitable as a high level textbook for graduate and upper level undergraduate courses.  The 7^th edition is organized into two main sections, first covering the basic aging processes and then the medical physiology of aging.  This puts less emphasis on research germane only to specific species and more emphasis on the mechanisms that affect aging across species, and what this means medically for the aging of humans.  This volume allows basic researchers to keep abreast of basic research outside their subdiscipline as well as recent clinical  findings, while allowing medical, behavioral, and social gerontologists to understand what basic scientists and clinicians are discovering.

Coverage of basic aging processes includes the effects of dietary restriction, somatotropic axis, free radicals, apoptosis, adipose tissue, stem cells, leukocyte telomere dynamics, genetics, sirtuins, inflammation, and protein homeostasis on aging.  Coverage of the medical physiology of aging includes several chapters on aging effects on the human brain including changes in brain myelination, cerebral microvasculature, and cerebral vascular dysfunction.    Additional chapters include research on aging pulmonary function, insulin secretion, thermoreception and thermoregulation, calorie restriction, frailty & mortality, and sex differences in longevity and aging.  This more clinically-oriented section advances our understanding  of what to expect, how to prevent, and how to treat common medical effects of aging.

The Handbook of the Biology of Aging, 7e is part of the Handbooks of Aging series, including Handbook of the Psychology of Aging and Handbook of Aging and the Social Sciences, also in their 7^th editions.

Handbook of the Biology of Aging, 7th Edition

Part I: Basic Aging Processes

1. The Genetic Network of Lifespan Extension by Dietary Restriction - Eric Greer and Anne Brunet

2. Role of the Somatotropic Axis in Mammalian Aging - Holly M.Brown-Borg

3. Mechanisms of Mitochondrial Free Radical Production and their Relationship to the Aging Process - Casey L. Quinlan, Jason R. Treberg, and Martin D. Brand

4. Aging and Apoptosis in Muscle - Stephen E. Alway, Michael R. Morissette, and Parco M. Siu

5. Aging and Adipose Tissue - Roberta Florido, Tamara Tchkonia, and James L. Kirkland

6. Aging of Stem Cells: Intrinsic Changes and Environmental Influences - Ling Liu and Thomas A. Rando

7. Leukocyte Telomere Dynamics, Human Aging and Lifespan - Abraham Aviv

8. An Unbiased Appraisal of the Free Radical Theory of Aging - Michael Lustgarten, Florian L. Muller, and Holly Van Remmen

9. TOR: A Conserved Nutrient-Sensing Pathway that Determines Life-Span Across Species - Pankaj Kapahi and Lutz Kockel

10. Comparative Genetics of Aging - George L. Sutphin and Matt Kaeberlein

11. Sirtuins in Aging and Age-Related Diseases - Marcia C. Haigis and David A. Sinclair

12. Inflammation in Aging Processes: An Integrative and Ecological Perspective - Caleb E. Finch

13. Protein Homeostasis and Aging - Susmita Kaushik and Ana Maria Cuervo

Part II: Medical Physiology of Aging

14. Terminal Weight Loss, Frailty, and Mortality - Edward J. Masoro

15. Human Brain Myelination Trajectories Across the Lifespan: Implications for CNS Function and Dysfunction - Jonathan E. Sherin and George Bartzokis

16. Aging and the Cerebral Microvasculature: Clinical Implications and Potential Therapeutic Interventions - Farzaneh A. Sorond and Lewis A. Lipsitz

17. Aging and Insulin Secretion - Jeffrey B. Halter

18. Cardiovascular Effects of Aging in Primates - Gender Differences - Hongyu Qiu, Christophe Depre, Dorothy E. Vatner, and Stephen F. Vatner

19. Cerebral Vascular Dysfunction with Aging - Frank M. Faraci

20. Pulmonary Function in Aging Humans - Nigel A.S. Taylor

21. Calorie Restriction in Nonhuman and Human Primates - Luigi Fontana, Ricki J. Colman, John O. Holloszy, and Richard Weindruch

22. Age-related Changes in Thermoreception and Thermoregulation - Eus J.W. Van Someren

23. Sex Differences in Longevity and Aging - Steven N. Austad