Therapeutic Applications of Quadruplex Nucleic Acids, 1st Edition

Therapeutic Applications of Quadruplex Nucleic Acids, 1st Edition

1. Intro - history and milestones
2. Fundamentals of DNA and RNA quadruplex structure and stability
3. Quadruplexes as therapeutic targets for telomeres and relationship to telomerase and telomere maintenance
4. Genomic DNA and RNA quadruplexes - involvement in gene expression and potential as therapeutic agents
5. Quadruplex targets and human disease - applicability in cancer and infectious disease, including oncogene targets such as c-myc and c-kit
6. Quadruplex ligands - chemistry and design - selectivity and assays
7. Quadruplex ligands - basic biology and assays indirect and direct
8. Quadruplex ligands - pharmacology and druggability, ligands in clinical trial and pre-clinical trial development
9. Synthetic quadruplexes and drugs - therapeutic aptamers, including thrombin, STAT3 binding, nucleolin binding
10. Future directions and conclusions