Basic Neurochemistry

Basic Neurochemistry, 8th Edition

Principles of Molecular, Cellular, and Medical Neurobiology

Basic Neurochemistry, 8th Edition,Scott Brady,George Siegel,R. Wayne Albers,Donald Price,ISBN9780123749475

Brady   &   Siegel   &   Albers   &   Price   

Academic Press




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Classic advanced neurochemistry/neurobiology textbook has been fully revised to incorporate clinical applications

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Key Features

The new edition features:

* Completely updated text with new authors and material, and many entirely new chapters
* Over 400 fully revised figures in splendid color
* 61 chapters covering the range of cellular, molecular and medical neuroscience
* Translational science boxes emphasizing the connections between basic and clinical neuroscience
* Companion website at http://elsevierdirect.com/companions/9780123749475


Basic Neurochemistry: Principles of Molecular, Cellular, and Medical Neurobiology, the outstanding and comprehensive classic text on neurochemistry, is now newly updated and revised in its Eighth Edition. For more than forty years, this text has been the worldwide standard for information on the biochemistry of the nervous system, serving as a resource for postgraduate trainees and teachers in neurology, psychiatry, and basic neuroscience, as well as for medical, graduate, and postgraduate students and instructors in the neurosciences. The text has evolved, as intended, with the science. It is also an excellent source of current information on basic biochemical and cellular processes in brain function and neurological diseases for continuing medical education and qualifying examinations. This text continues to be the standard reference and textbook for exploring the translational nature of neuroscience, bringing basic and clinical neuroscience together in one authoritative volume. Our book title reflects the expanded attention to these links between neurochemistry and neurologic disease.

This new edition continues to cover the basics of neurochemistry as in the earlier editions, along with expanded and additional coverage of new research from: Intracellular trafficking; Stem cells, adult neurogenesis, regeneration; Lipid messengers; Expanded coverage of all major neurodegenerative and psychiatric disorders; Neurochemistry of addiction; Neurochemistry of pain; Neurochemistry of hearing and balance; Neurobiology of learning and memory; Sleep; Myelin structure, development, and disease; Autism; and Neuroimmunology.


Advanced undergraduates, graduate students and post-docs in neuroscience or biomedical science, medical students, clinical neuroscientists and neurologists

Scott Brady

Affiliations and Expertise

University of Illinois, Chicago IL

George Siegel

Affiliations and Expertise

Loyola University, Chicago, IL, USA

R. Wayne Albers

OBITUARY FOR R. WAYNE ALBERS, August 5, 1928 - September 28, 2013 R. Wayne Albers, Ph.D., Scientist Emeritus, Chief of Section on Enzyme Chemistry (retired), Laboratory of Neurochemistry in the NINDS, NIH, Bethesda, MD, is a world-recognized neuroscientist most noted for his research in the field of membrane cation transport and neuronal excitability in the nervous system. Dr. Albers and physiologist R.L. Post performed the principal experiments leading to their now widely-held Albers-Post model for the mechanism of the cation transport enzyme, sodium-potassium-activated ATPase. Dr. Albers was one of the founding co-editors of the comprehensive text, Basic Neurochemistry: Molecular, Cellular and Medical Aspects, first published in 1972, continuing as co-editor for 8 editions, the latest having been published in 2012. After receiving his PhD at Washington University School of Medicine in 1954, Dr. Albers embarked on a distinguished career of research at the NIH, being a founding investigator in the first Laboratory of Neurochemistry. Dr. Albers was one of the first members of the American Society for Neurochemistry at its inception, serving on its Council and its Committees on Publications and Education and on Electronic Publications. He has served as Professor of Biochemistry at George Washington University, Faculty Member of the NIH Foundation for Advanced Education in the Sciences, Associate Editor of the Journal of Neurochemistry and of Experimental Neurology, and on the editorial boards of several journals. Dr. Albers passed away on September 28, 2013. He was 85 years old and is survived by his former wife, Frances Albers, their children Gail Morrell, Belinda Caron and Patricia Steinhoff, 6 grandchildren, and 8 great-grandchildren. He also had a son, the late Jonathan Albers. Dr. Albers was considered a gentleman, an excellent scientific colleague with a keen intellect and friend by all who worked with him. He will be sorely missed, not only by his family, but also by the entire neurochemistry community. George J. Siegel October 1, 2013

Affiliations and Expertise

National Institutes of Health, Bethesda MD, USA

Donald Price

Affiliations and Expertise

The Johns Hopkins University School of Medicine, Baltimore MD

Basic Neurochemistry, 8th Edition

Part I: Cellular Neurochemistry and Neural Membranes
Cell Biology of the Nervous System
Cell Membrane Structures and Functions
Membrane Transport
Electrical Excitability and Ion Channels
The Cytoskeleton of Neurons and Glia
Intracellular Trafficking
Axonal Transport
Cell Adhesion Molecules
Myelin Structure and Biochemistry
Energy Metabolism of the Brain

PART II: Intercellular Signaling
Synaptic Transmission and Cellular Signaling: An Overview
Glutamate and Glutamate Receptors
Purinergic Signaling

PART III: Intracellular Signaling
G Proteins
Cyclic Nucleotides in the Nervous System
Serine and Threonine Phosphorylation
Tyrosine Phosphorylation
Transcription Factors in the Central Nervous System

PART IV: Growth, Development and Differentiation
Development of the Nervous System
Growth Factors
Stem Cells in the Nervous System
Formation and Maintenance of Myelin
Axonal Growth in the Adult Mammalian Nervous System

PART V: Cell Injury and Inflammation
Molecular Mechanisms and Consequences of Immune and Nervous System Reactions
Brain Ischemia and Reperfusion: Cellular and Molecular Mechanisms in Stroke Injury
Lipid Mediators: Eicosanoids, Docosanoids and Platelet-Activating Factor
Apoptosis and Necrosis

PART VI: Inherited and Neurodegenerative Diseases
Peripheral Neuropathy
Diseases Involving Myelin
The Epilepsies: Phenotypes and Mechanisms
Genetics of Neurodegenerative Diseases
Disorders of Amino Acid Metabolism
Inborn Metabolic Defects of Lysosomes, Peroxisomes, Carbohydrates, and Fatty Acids and Mitochondria
Disorders of Muscle Excitability
Motor Neuron Diseases
Neurobiology of Alzheimer's Disease
Synucleinopathies and Tauopathies
Cellular and Molecular Basis of Neurodegeneration in the CAG-Polyglutamine Repeat Diseases
Neurotransmitters and Disorders of the Basal Ganglia
Molecular Basis of Prion Diseases

PART VII: Sensory Transduction
Molecular Biology of Vision
Molecular Biology of Olfaction and Taste
Molecular Biology of Hearing and Balance

PART VIII: Neural Processing and Behavior
Endocrine Effects on the Brain and Their Relationship to Behavior
Learning and Memory
The Neurochemistry of Sleep and Wakefulness
The Neurochemistry of Schizophrenia
The Neurochemistry of Autism
Neurobiology of Severe Mood and Anxiety Disorders

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