Essentials of Stem Cell Biology

Essentials of Stem Cell Biology, 2nd Edition

Essentials of Stem Cell Biology, 2nd Edition,Robert Lanza,John Gearhart,Brigid Hogan,Douglas Melton,Roger Pedersen,E. Donnall Thomas,James Thomson,Ian Wilmut,ISBN9780080884974

Lanza   &   Gearhart   &   Hogan   &   Melton   &   Pedersen   &   Thomas   &   Thomson   &   Wilmut   

Academic Press



The only source which provide first hand accounts of the latest stem cell research from the leading experts

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Key Features

  • Selected for inclusion in Doody's Core Titles 2013, an essential collection development tool for health sciences libraries
  • Contributions by Nobel Laureates and leading international investigators
  • Includes two entirely new chapters devoted exclusively to induced pluripotent stem (iPS) cells written by the scientists who made the breakthrough
  • Edited by a world-renowned author and researcher to present a complete story of stem cells in research, in application, and as the subject of political debate
  • Presented in full color with glossary, highlighted terms, and bibliographic entries replacing references


First developed as an accessible abridgement of the successful Handbook of Stem Cells, Essentials of Stem Cell Biology serves the needs of the evolving population of scientists, researchers, practitioners and students that are embracing the latest advances in stem cells. Representing the combined effort of seven editors and more than 200 scholars and scientists whose pioneering work has defined our understanding of stem cells, this book combines the prerequisites for a general understanding of adult and embryonic stem cells with a presentation by the world's experts of the latest research information about specific organ systems. From basic biology/mechanisms, early development, ectoderm, mesoderm, endoderm, methods to application of stem cells to specific human diseases, regulation and ethics, and patient perspectives, no topic in the field of stem cells is left uncovered.


researchers, grad students, and professionals working with human stem cells in biology, tissue engineering, genetics, cancer research, virology, immunology, and biotechnology

Robert Lanza

Robert Lanza, M.D. is currently Chief Scientific Officer at Advanced Cell Technology, and Adjunct Professor of Surgical Sciences at Wake Forest University School of Medicine. He has several hundred scientific publications and patents, and over 30 books, including Principles of Tissue Engineering (1st through 4th Editions), Methods of Tissue Engineering, Principles of Cloning (1st and 2nd Editions), Essentials of Stem Cell Biology (1st and 2nd Editions), XENO, Yearbook of Cell & Tissue Transplantation, One World: The Health & Survival of the Human Species in the 21st Century (as editor, with forewords by C. Everett Koop and former President Jimmy Carter), and Medical Science & the Advancement of World Health. Dr. Lanza received his B.A. and M.D. degrees from the University of Pennsylvania, where he was both a University Scholar and Benjamin Franklin Scholar. He is a former Fulbright Scholar, and studied as a student in the laboratory of Richard Hynes (MIT), Jonas Salk (The Salk Institute), and Nobel laureates Gerald Edelman (Rockefeller University) and Rodney Porter (Oxford University). He also worked closely (and coauthored a series of papers) with the late Harvard psychologist B.F. Skinner and heart transplant pioneer Christiaan Barnard. Dr. Lanza's current area of research focuses on the use of stem cells in regenerative medicine.

Affiliations and Expertise

Advanced Cell Technology, MA, USA

View additional works by Robert Lanza

John Gearhart

Affiliations and Expertise

Johns Hopkins University School of Medicine, Baltimore, MD, USA

Brigid Hogan

Affiliations and Expertise

Duke University Medical Center, Durham, NC, USA

Douglas Melton

Affiliations and Expertise

Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA

Roger Pedersen

Affiliations and Expertise

Department of Surgery, University of Cambridge, Addenbrooke's Hospital, UK

E. Donnall Thomas

Affiliations and Expertise

Director Emeritus, Fred Hutchinson Cancer Research Center, Seattle, WA, USA

James Thomson

Affiliations and Expertise

Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, USA

View additional works by James A. Thomson

Ian Wilmut

Affiliations and Expertise

Director, MRC Centre for Regenerative Medicine, Edinburgh, UK

View additional works by Ian Sir Wilmut

Essentials of Stem Cell Biology, 2nd Edition


Why Stem Cell Research?
A New Path ?{ Induced Pluripotent Stem Cells
Embryonic Stem Cells Versus Adult Stem Cells
'Stemness': Definitions, Criteria and Standards

1. Present Perspective and Future Challenges
2. Embryonic Stem Cells in Perspective
3. The Development of Epithelial Stem Cell Concepts
4. The Advent of Direct Reprogramming
5. Clinical Translation of Stem Cells

6. Molecular Basis of Pluripotency
7. Stem Cell Niches
8. Mechanisms of Stem Cell Self-Renewal
9. Cell Cycle Regulators in Stem Cells
10. Epigenetic Mechanisms of Cellular Memory
11. Cell Fusion and the Differentiated State
12. How Cells Change Their Phenotype

13. Differentiation in Early Development
14. Primordial Germ Cells in Mouse and Human
15. Stem Cells in Extraembryonic Lineages
16. Amniotic Fluid Derived Pluripotent Cells
17. Cord Blood Stem Cells
18. Neurogenesis in the Vertebrate Embryo
19. The Nervous System
20. Neuronal Progenitors in the Adult Brain
21. Sensory Epithelium of the Eye and Ear
22. Epithelial Skin Stem Cells
23. The Ontogeny of the Hematopoietic System
24. Hematopoietic Stem Cells
25. Red Blood Cells
26. Cell Differentiation in the Skeleton
27. Vascular Progenitor Cells
28. Multipotent Adult Progenitor Cells
29. Mesenchymal Stem Cells
30. Skeletal Muscle Stem Cells
31. Stem Cells and the Regenerating Heart
32. Potential of ES Cell Differentiation Culture for Vascular Biology
33. Cell Lineages and Stem Cells in the Kidney
34. Adult Liver Stem Cells
35. Pancreatic Stem Cells
36. Stem Cells in the Gastrointestinal Tract
37. Stem Cells in the Lung

38. Generation of Induced Pluripotent Stem Cells
39. Characteristics and Characterization of Pluripotent Stem Cells
40. Isolation and Maintenance of Murine Embryonic Stem Cells
41. Isolation, Characterization, and Maintenance of Primate ES Cells
42. Approaches for Derivation and Maintenance of Human ES cells:
Detailed Procedures and Alternatives
43. Derivation and Differentiation of Human EG Cells
44. Growth Factors & the Serum-Free Culture of Human Pluripotent Stem Cells
45. Feeder-Free Culture
46. Genetic Manipulation of Human Embryonic Stem Cells
47. Homologous Recombination in Human Embryonic Stem Cells
48. Surface Antigen Markers
49. Lineage Marking
50. Genomic Reprogramming
51. Isolation and Characterization of Hematopoietic Stem Cells
52. Microarray Analysis of Stem Cells and Differentiation
53. Zebrafish and Stem Cell Research

54. Cancer Stem Cells
55. Neural Stem Cells: Therapeutic Applications in Neurodegenerative Diseases
56. Spinal Cord Injury
57. Use of Embryonic Stem Cells to Treat Heart Disease
58. Insulin-Producing Cells Derived from Stem Cells: A Potential Treatment for Diabetes
59. Burns and Skin Ulcers 978-0-12-370465-8
60. Stem Cells and Heart Disease
61. Stem Cells for the Treatment of Muscular Dystropy
62. Skin Regeneration
63. Orthopaedic Applications of Stem Cells
64. Embryonic Stem Cells in Tissue Engineering
65. Adult Stem Cells in Tissue Engineering
66. Stem Cell Gene Therapy

67. Ethical Considerations
68. Religious Considerations
69. Regulatory Considerations
70. It¡¦s Not About Curiosity, It¡¦s About Cures
Epilogue: Concluding Statement
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