Mouse Models of Developmental Genetic Disease

Mouse Models of Developmental Genetic Disease, 1st Edition

Mouse Models of Developmental Genetic Disease, 1st Edition,Robert Krauss,ISBN9780123744548

Current Topics in Developmental Biology

R Krauss   

Academic Press




229 X 152

Reviews the current research findings on the development of a variety of human diseases, using mouse as the mammalian model.

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Key Features

* Provides busy clinical and basic science researchers a one-stop overview and synthesis of the latest research findings and contemporary thought in the area
* Allows researchers to compare and contrast disease models and also to learn about what models have been developed for large-scale distribution
* Allows researchers to evaluate basic differences in mouse and human biology and propose alternate pathways and possible gene interactions of the disease


Approximately three percent of newborn humans have congenital anomalies with significant cosmetic and/or functional consequences. Much of our ability to understand what has gone awry in these birth defects rests with development of animal models for them; the mouse has emerged as the model organism of choice for these studies. This volume reviews mouse models of specific developmental genetic diseases, including neural tube defects; cleft lip and/or palate; congenital heart disease; ciliopathies; hereditary deafness and others to provide conceptual insight into congenital anomalies generally. The interplay between clinical observation and murine model systems is expected to yield deep insight into mammalian developmental processes and the emergence of effective preventive and/or therapeutic strategies.


Graduate students and scientists in developmental biology

Robert Krauss

Affiliations and Expertise

Mount Sinai School of Medicine, New York, USA

Mouse Models of Developmental Genetic Disease, 1st Edition

1) Comprehensive Phenotyping of Genetically Modified Mice to Identify New Target Disease Indications
Author: Sandra Engle

2) Modeling the Repair Process in Multiple Sclerosis
Author: H. Arnett

3) Mouse Genetic Models for Individualized Symptomatology of Cancer and Infectious Disease
Author: P. Demant

4) New Rodent Models for Obesity, Diabetes, and Metabolic Syndrome
Author: R. Peterson

5) Mouse Models of Huntingdon’s Disease
Author: L. Menalled, M. Chesselet

6) Mouse Models for Ocular Disease
Author: L. Molday

7) Hyperlipidemia-Induced Atherosclerosis
Author: A. Daugherty

8) Mouse Models for Mitochondrial Disease
Authors: D. Wallace

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